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Cancer Drug Resistance
Leading experts summarize and synthesize the latest discoveries concerning the changes that occur in tumor cells as they develop resistance to anticancer drugs, and suggest new approaches to preventing and overcoming it. The authors review physiological resistance based upon tumor architecture, cellular resistance based on drug transport, epigenetic changes that neutralize or bypass drug cytotoxicity, and genetic changes that alter drug target molecules by decreasing or eliminating drug binding and efficacy. Highlights include new insights into resistance to antiangiogenic therapies, oncogenes and tumor suppressor genes in therapeutic resistance, cancer stem cells, and the development of more effective therapies. There are also new findings on tumor immune escape mechanisms, gene amplification in drug resistance, the molecular determinants of multidrug resistance, and resistance to taxanes and Herceptin.
The Genealogy and History of the Family of Williams in America
Robert Williams and his wife, Elizabeth Stratton (d. 1674), had at least four sons, 1632-1640 or after. They immigrated to America ca. 1638 and settled at Roxbury, Massachusetts. He died in 1693. Descendants listed lived in Massachusetts, New York, and elsewhere.
Columbus Directory
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Air Force Register
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