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Cancer Drug Resistance
  • Language: en
  • Pages: 611

Cancer Drug Resistance

Leading experts summarize and synthesize the latest discoveries concerning the changes that occur in tumor cells as they develop resistance to anticancer drugs, and suggest new approaches to preventing and overcoming it. The authors review physiological resistance based upon tumor architecture, cellular resistance based on drug transport, epigenetic changes that neutralize or bypass drug cytotoxicity, and genetic changes that alter drug target molecules by decreasing or eliminating drug binding and efficacy. Highlights include new insights into resistance to antiangiogenic therapies, oncogenes and tumor suppressor genes in therapeutic resistance, cancer stem cells, and the development of more effective therapies. There are also new findings on tumor immune escape mechanisms, gene amplification in drug resistance, the molecular determinants of multidrug resistance, and resistance to taxanes and Herceptin.

The Genealogy and History of the Family of Williams in America
  • Language: en
  • Pages: 470

The Genealogy and History of the Family of Williams in America

  • Type: Book
  • -
  • Published: 1847
  • -
  • Publisher: Unknown

Robert Williams and his wife, Elizabeth Stratton (d. 1674), had at least four sons, 1632-1640 or after. They immigrated to America ca. 1638 and settled at Roxbury, Massachusetts. He died in 1693. Descendants listed lived in Massachusetts, New York, and elsewhere.

Report of the Adjutant General of the Indiana Militia to the Governor
  • Language: en
  • Pages: 712

Report of the Adjutant General of the Indiana Militia to the Governor

  • Type: Book
  • -
  • Published: 1866
  • -
  • Publisher: Unknown

None

Rules of Agreement, Etc
  • Language: en
  • Pages: 38

Rules of Agreement, Etc

  • Type: Book
  • -
  • Published: 1832
  • -
  • Publisher: Unknown

None

Official Register of the United States
  • Language: en
  • Pages: 1290

Official Register of the United States

  • Type: Book
  • -
  • Published: 1897
  • -
  • Publisher: Unknown

None

Columbus Directory
  • Language: en
  • Pages: 252

Columbus Directory

  • Type: Book
  • -
  • Published: 1866
  • -
  • Publisher: Unknown

None

Air Force Register
  • Language: en
  • Pages: 940

Air Force Register

  • Type: Book
  • -
  • Published: 1959
  • -
  • Publisher: Unknown

None

Loftus's almanack for the wine, beer and spirit trades
  • Language: en
  • Pages: 1210

Loftus's almanack for the wine, beer and spirit trades

  • Type: Book
  • -
  • Published: Unknown
  • -
  • Publisher: Unknown

None