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This book is a timely textbook that covers all aspects of neuroendocrine tumors (NET) from epidemiology, pathological classification and evaluation and molecular biology through to diagnostic imaging methods and therapeutic options, including the latest targeted therapies. The various types of NET are individually discussed, including carcinoid tumors, insulinomas, gastrinomas, glucagonomas, VIPomas, somatostatinomas, PPomas, medullary thyroid carcinomas, adrenocortical cancer, pheochromocytomas, paragangliomas and non-functioning pancreatic NETs. The contributing authors are internationally recognized experts who bring a wealth of experience to the subject. This book will be an invaluable source of information for practicing medical oncologists, surgeons, endocrinologists, gastroenterologists and pathologists and also trainees.
Gastrointestinal Oncology: A Critical Multidisciplinary Team Approach is the first evidence-based reference text designed for the multidisciplinary team of medical professionals involved in the investigation, diagnosis, and management of patients with gastrointestinal cancer. Written and edited by leading international experts in the field it sets the standard in clinical practice for dealing with esophageal, gastric, intestinal, colonic, hepatobiliary, pancreatic, and other GI tumors. The book is divided into twenty-five clinical chapters each addressing the specific cancers affecting the gastrointestinal tract. Each chapter is written by a team of authors, with each contributor specially c...
This book outlines some new advances in genetics, clinical evaluation, localization, therapy (newly including immunotherapy) of pheochromocytoma and paraganglioma including their metastatic counterparts. Well-known and experienced clinicians and scientists contributed to this book to include some novel approaches to these tumors. This book will serve to various health care professionals from different subspecialties, but mainly oncologists, endocrinologists, endocrine surgeons, pediatricians, and radiologists. This book shows that the field of pheochromocytoma/paraganglioma is evolving and a significant progress has been made in last 5 years requiring that health care professionals and scientists will learns new information and implement it in their clinical practice or scientific work, respectively. This book should not be missed by anybody who is focusing on neuroendocrine tumors, their newest evaluation and treatment.
Pheochromocytomas are rare, mostly benign tumors of the adrenal medulla whose symptoms are caused by a tumor-induced secretion of catecholamines. This book provides an overview of current knowledge on the clinical situation, diagnosis and therapy of the disease as well as an extensive discussion of novel aspects in the molecular basis of this disease such as the recognition of new tools in molecular biology. The endocrine diagnosis is based on precise knowledge of tumor metabolism of catecholamines and their metabolites and today comprises laboratory methods with a high sensitivity and specificity. As approximately one quarter of these tumors arise in the context of a familial disease, such ...
Cushing ́s syndrome is a relatively rare clinical disorder that is associated with many co-morbidities such as systemic hypertension, diabetes, osteoporosis, impaired immune function and growth impairment in children, all of which severely reduce quality of life and life expectancy. Cushing’s Syndrome: Pathophysiology, Diagnosis and Treatment reviews the difficulties in distinguishing Cushing’s syndrome from these and other common conditions, such as central obesity, menstrual irregularity and depression. It also provides state-of-the-art information on various strategies to establish the diagnosis of Cushing’s syndrome and the differential diagnosis among its diverse etiologies, as w...
The prevalence of hypertension is almost three times as high as that of diabetes mellitus type 2, with both conditions being major risk factors for stroke, ischemic heart disease, cardiac arrhythmias, and heart failure. The exact prevalence of hypertension related to hormonal derangements (endocrine hypertension) is not known but estimated to affect less than 15% of hypertensive patients. Recent scientific discoveries have increased the understanding of the pathophysiologic mechanisms of hypertension. In Endocrine Hypertension, a renowned panel of experts provides a comprehensive, state-of-the-art overview of this disorder, discussing when to assign an endocrine cause in one of many conditio...
This book provides a broad overview of pancreatic neuroendocrine neoplasms, focusing on the most important developments in the technologies used to diagnose, classify and treat them. After a historical and epidemiological overview, the opening chapters examine the various diagnostic approaches (radiology, nuclear medicine, endocrinology, cytology and immunohistochemistry) and discuss the WHO classification. The functioning and nonfunctioning tumor types are then fully discussed, covering epidemiology, diagnosis, morphology and prognosis of each entity. Careful consideration is given to the molecular features that have contributed in understanding the pathogenesis of such neoplasms and may have potential implications for the diagnostic and therapeutic pathways. The final chapters consider the surgical and medical approaches to therapy, providing a practical and analytical overview of the available options. The book is written by a multidisciplinary team of worldwide-recognized experts and is addressed to radiologists, nuclear medicine physicians, endocrinologists, pathologists, surgeons and oncologists.
Neuroendocrinology underpins fundamental physiological, molecular, biological, and genetic principles such as the regulation of gene transcription and translation. This handbook highlights the experimental and technical foundations of each area's major concepts and principles.
This 'Neuroendocrinology' special issue provides a collection of papers generated at the first consensus conference devoted to gastrointestinal neuroendocrine tumors. The conference was held in Frascati (Rome, Italy) in November 2005. The focus was on neuroendocrine tumors of foregut origin, stomach, duodenum and pancreas. A standard approach based on WHO tumors classification was adopted with 63 experts and practicing clinicians confronting their experience and evidence-based data to devise effective strategies for the management of patients with this neglected cancer disease. Papers are organized on an anatomical basis, specific issues are discussed and minimal consensus statements defined...