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Non Pharmacological Therapies in the Management of Osteoarthritis
Osteoarthritis is a chronic disease prevalent among the elderly. Its most prominent feature is the progressive destruction of articular cartilage which results in impaired joint motion, severe pain and ultimately disability. Its prevalence and its impact on daily life pose a significant public health problem. Today, a cure for osteoarthritis remains elusive and the management of the disease is largely palliative, focusing on the alleviation of symptoms. Current recommendations include a combination of pharmacological and non-pharmacological treatments. The term “non-pharmacological” includes physical therapy and rehabilitation, but also nutraceuticals. All guidelines on osteoarthritis ma...
Physiology and Pathophysiology of Musculoskeletal Aging
We live in a world with an ever-increasing aging population. This aging population is predicted to place a huge financial burden on healthcare systems around the world. Understanding healthy ageing is a key research priority, along with a better understanding of the pathophysiology of ageing that occurs in a number of age related diseases, such as arthritis. By gaining a better understanding of healthy musculoskeletal ageing we can provide better care and new therapies for common musculoskeletal problems. This Research Topic is intended to bring together basic researchers and clinicians working in the broad area of musculoskeletal ageing. The topic includes mechanisms of healthy ageing in the musculoskeletal system, which we define as skeletal muscle and the synovial joint, particularly constituent structures including articular cartilage, subchondral bone tendon and ligament. A particular focus of this Research Topic is dietary modulation of musculoskeletal ageing.
New Trends in Osteoarthritis Treatment
Osteoarthritis can be categorized as the deterioration of protective cartilage surrounding joints resulting in swelling, pain and increased difficulty in joint movement. Several factors are known to increase risk of osteoarthritis such as joint injury, comorbidity with other conditions (rheumatoid arthritis), age and obesity. While joint damage is irreversible, symptoms can be managed and various life-style changes can slow disease progression. To date, there is no cure for osteoarthritis and while joint damage is irreversible, symptoms can be managed with various life-style changes to slow disease progression. Pain management can often be achieved with over-the-counter analgesics. Alternatives include Non-steroidal anti-inflammatory drugs (NSAIDs), Opioids, Capsaicin cream, and in extreme cases Steroid injections. Non-pharmaceutical treatments include physiotherapy, assisted devices such as specialized footwear and transcutaneous electrical nerve stimulation (TENS). In cases of extreme joint damage various surgeries may be available to patients, such as arthroplasty surgery.
Mechanosensitivity and Mechanotransduction
This book presents the latest findings in the field of research of mechanosensitivity and mechanotransduction in different cells and tissues. Mechanosensitivity and mechanotransduction of the heart and vascular cells, in the lung, in bone and joint tissues, in sensor systems and in blood cells are described in detail. This Volume focuses on molecular mechanisms of mechanosensitivity and mechanotransduction via cytoskeleton. Integrin-mediated mechanotransduction, the role of actin cytoskeleton and the role of other cytoskeletal elements are discussed. It contains a detailed description of several stretch-induced signaling cascades with multiple levels of crosstalk between different pathways. ...
Studies on Arthritis and Joint Disorders
This next volume in our established series proposes to systematically review the basic science and clinical knowledge of the role of free radicals and antioxidants, collectively known as “oxidative stress”, in the pathology of arthritis and other joint diseases. It will describe the most current diagnostic tools , laboratory methods and technology, to suggest ways of prevention and treatment and to emphasize the concept of the bench-to-bedside approach. The book will also provide specific coverage on emerging technology and medical applications including discussions of biomarkers and antioxidants as therapeutic agents and several more relevant aspects. In addition, the book will promote the concept of using biomarkers representative of oxidative stress reactions and free radical damage , as well as describe the effect of antioxidants in treating disease in clinical trials. The content will be valuable to researchers studying the development of arthritis/joint disease, and clinicians treating patients with these diagnoses.
What Your Doctor Hasn't Told You and the Health-Store Clerk Doesn't Know
Millions of Americans turn to alternative medicine to treat chronic health problems when conventional medicine fails. Yet few doctors-or health store clerks and alternative practitioners-know what treatments are safe and effective. In this book, Edward Schneider, a leading researcher and clinician at the University of Southern California, arms readers with an overview of the latest medical research, then offers a proven formula for the best integrative therapy available to treat the most common health issues. From supplements and herbs, to acupuncture and yoga, What Your Doctor Hasn't Told You and the Health Store Clerk Doesn't Know outlines the myriad therapies used for: - sleep problems - joint, back, and neck pain - depression and anxiety - PMS and menopause - prostate health - heart disease and cancer - memory loss, and more An authoritative yet friendly guide, complete with hard-to-find dosage guidelines and advice on what therapies are just not worth your money, and packed with the type of information readers can take to the health store aisles and to their doctor, this book is essential reading for anyone considering alternative remedies.
Genomics, Proteomics and Metabolomics in Nutraceuticals and Functional Foods
Functional foods and nutraceuticals have received considerable interest in the past decade largely due to increasing consumer awareness of the health benefits associated with food. Diet in human health is no longer a matter of simple nutrition: consumers are more proactive and increasingly interested in the health benefits of functional foods and their role in the prevention of illness and chronic conditions. This, combined with an aging population that focuses not only on longevity but also quality of life, has created a market for functional foods and nutraceuticals. A fully updated and revised second edition, Genomics, Proteomics and Metabolomics in Nutraceuticals and Functional Foods reflects the recent upsurge in "omics" technologies and features 48 chapters that cover topics including genomics, proteomics, metabolomics, epigenetics, peptidomics, nutrigenomics and human health, transcriptomics, nutriethics and nanotechnology. This cutting-edge volume, written by a panel of experts from around the globe reviews the latest developments in the field with an emphasis on the application of these novel technologies to functional foods and nutraceuticals.
Mechanical Stretch and Cytokines
This book presents the latest findings in the field of investigation of molecular mechanisms of mechanical stretch and the role of cytokines in response of different tissues to it. On the one hand this Volume demonstrates how mechanical stretch enhances cytokines production. It describes how cytokines influence tissues and cells on a background of a mechanical stretching. It provides a description of how cells in different tissues are activated by stretch and cytokines via various signaling pathways, and how they change their gene expression. The book is a unique collection of reviews outlining current knowledge and future developments in this rapidly growing field. Knowledge of biomechanics, and mechanisms which underlie it on molecular, cellular and tissue, is necessary for understanding of the normal functioning of living organisms and allows to predict changes, which arise due to alterations of their environment.
