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20 Years of Cell Death
In 1994, when the International Cell Death Society was founded, programmed cell death and apoptosis had just recently been recognized as major factors in medicine, important in diseases such as cancer, neurodegenerative diseases, autoimmune diseases, and developmental anomalies. The biomedical world had accepted the idea that most cells do not die by accident: under specific conditions, they commit suicide, leading either to protection of the organism or damage to it. In the last 20 years, we have come to understand a great deal about cell death. It is a major research field, and one that is considered in all medical research. In this book, many of the pioneers and leading researchers recoun...
Programmed Cell Death
The 2002 Nobel Prize in Physiology or Medicine was awarded to Sydney Brenner (UK),H. Robert Horvitz (US)and John E. Sulston (UK) "for their discoveries concerning genetic regulation of organ development and programmed cell death." Cell death is a fundamental aspect of embryonic development, normal cellular turnover and maintenance of homeostasis (maintaining a stable, constant environment) on the one hand, and aging and disease on the other. This volume addresses the significant advances with the techniques that are being used to analyze cell death. *Provides the necessary, trusted methods to carry out this research on the latest techniques. Once researchers understand the molecular mechanisms of the apoptotic pathways, they can begin to develop new therapies *Presents key methods on studying tumors and how these cancer cells evade cell death *Eliminates searching through many different sources to avoid pitfalls so the same mistakes are not made over and over
Apoptosis Methods and Protocols
The most fundamental question facing each and every cell within an org- ism is to survive or to die. Cell death is required for normal function; some estimates suggest that as many as one million cells undergo cell death every second in the adult human body. Almost all cells undergoing physiological, or programmed, cell death, independent of cell type, manifest a stereotypic p- tern of morphological changes termed apoptosis. Typically, apoptotic cells d- play shrinkage, membrane blebbing, chromatin condensation, and nuclear fragmentation. The integrity of the cell membrane is not lost during apoptosis and so avoids eliciting the inflammatory response that would have been caused by the spilla...
When Cells Die
When Cells Die A Comprehensive Evaluation of Apoptosis and Programmed Cell Death Edited by Richard A. Lockshin, Zahra Zakeri, and Jonathan L. Tilly Cell death is fast becoming one of the most dynamic areas of biological research -involving as it does the study of apoptosis and programmed cell death and the role these phenomena play in development and homeostasis on the one hand, and aging and disease on the other. The profound implications for medicine and agriculture from the manipulation of these processes have spawned a deluge of research papers, articles, approaches, and methods -making it difficult for scientists to get an overview of the field. When Cells Die establishes a coherent fra...
Mechanisms of Cell Death
Contains papers from a July 1998 conference held at the Queens College Campus of the City University of New York. Papers are arranged in sections on mechanisms and general considerations, programmed (developmental) cell death, and cell death and pathological and clinical situations. Specific topics
Programmed Cell Death in Cancer Progression and Therapy
Programmed cell death (PCD) plays pivotal roles in tumor progression, cancer therapeutics and resistance of tumor cells to therapy. This book examines the mechanisms involved in mediating and regulating PCD in cancer. It also provides a detailed indication of the utility of PCD in cancer therapy. The book features chapters on the current and future of RNA interference in therapeutics and Pathways involved in Stem Cell Survival and Death.
When Cells Die II
Offers the most thorough, cutting-edge coverage of the field of cell death since publication of the first edition. Leading international researchers present an up-to-date yet accessible survey ranging from the history of cell death science to its modern methodology. Extensively revised, this new edition features relavant discussions of: the impact of genomics and proteomics; gene therapy and pharmacogenetics; the role of mitochondria; caspase-independent and non-apoptotic cell death; and evolution of mechanisms.
Programmed Cell Death
One of the major goals of researchers in the field of apoptosis is to identify targets for novel therapies in cancer, AIDS, and Alzheimer’s disease. Understanding the molecular mechanisms of the various components of the apoptotic pathways is the first step to reaching this goal. The 2002 Nobel Prize in Physiology or Medicine was awarded to Sydney Brenner (United Kingdom), H. Robert Horvitz (US) and John E. Sulston (UK) "for their discoveries concerning genetic regulation of organ development and programmed cell death." Cell death is a fundamental aspect of embryonic development, normal cellular turnover and maintenance of homeostasis (maintaining a stable, constant environment) on the one...
Methods in Protein Design
This new volume of Methods in Enzymology continues the legacy of this premier serial by containing quality chapters authored by leaders in the field. This volume covers methods in protein design and it has chapters on such topics as protein switch engineering by domain insertion, evolution based design of proteins, and computationally designed proteins. Continues the legacy of this premier serial with quality chapters authored by leaders in the field Covers methods in protein design Contains chapters with such topics as protein switch engineering by domain insertion, evolution-based design of proteins, and computationally designed proteins
Imaging and Spectroscopic Analysis of Living Cells
This volume of Methods in Enzymology is the first of three parts looking at current methodology for the imaging and spectroscopic analysis of live cells. The chapters provide hints and tricks not available in primary research publications. It is an invaluable resource for academics, researchers and students alike. Expert authors who are leaders in the field Extensively referenced and useful figures and tables Provides hints and tricks to facilitate reproduction of methods
