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Molecular Aspects of the Stress Response: Chaperones, Membranes and Networks
This book makes a novel synthesis of the molecular aspects of the stress response and long term adaptation processes with the system biology approach of biological networks. Authored by an exciting mixture of top experts and young rising stars, it provides a comprehensive summary of the field and identifies future trends.
Liver Cirrhosis
The liver is a large organ that sits in the right upper abdomen, just under the right lung. It is one of the body's most 'intelligent' organs in that it performs so many different functions at the same time. The liver makes proteins, eliminates waste material from the body, produces cholesterol, stores and releases glucose energy and metabolises many drugs used in medicine. It also produces bile that flows through bile ducts into the intestine where it helps to digest food. This organ also has the ability to regenerate itself if it is injured or partially removed. Cirrhosis is scarring of the liver that involves the formation of fibrous (scar) tissue associated with the destruction of the no...
Current Challenges in Complement Diagnostics
The complement system is an important innate immune surveillance network that has a key role in protecting our bodies against pathogens and other threats. It is a highly complex system consisting of approximately 50 soluble and cell surface-bound proteins that interact to eliminate danger signals. These signals include factors such as invading microorganisms, necrotic cells, and immune complexes. Furthermore, complement can link innate and adaptive immune responses by regulating T cell and B cell responses. The complement system is tightly regulated to avoid uncontrolled activation. Dysregulation of the complement system has been linked to numerous diseases, both rare and common. Uncontrolle...
Contemporary Challenges in Immunologic Testing in Clinical and Research Laboratories
Along the last several decades, it has been progressively appreciated that immunology plays an overwhelming role in the physiology and pathophysiology of most organs, tissues, and biological systems in multicellular organisms. Accordingly, several immunological parameters are used in research and clinical laboratories with the purpose of investigating, diagnosing, and monitoring a variety of pathological conditions. The rapidly evolving field of laboratory testing in immunology poses several challenges to professionals working in research and clinical laboratories, medical practice, educational activities, in vitro diagnostic industry, and regulatory agencies. Regular analytes, such as album...
The Biology of Extracellular Molecular Chaperones
The heat shock, or cell stress, response was first identified in the polytene chromosomes of Drosophila. This was later related to the appearance of novel proteins within stressed cells, and the key signal stimulating this appearance was identified as the presence of unfolded proteins within the cell. It is now known that this is a key mechanism enabling cells to survive a multitude of physical, chemical and biological stresses. Since the promulgation of the ‘molecular chaperone’ concept as a general cellular function to control the process of correct protein folding, a large number of molecular chaperones and protein folding catalysts have been identified, and it has been recognized tha...
Multietnikus világok Közép-Európában, 1867−1944 Multietnické prostredie v Strednej Európe, 1867 - 1944. Szerkesztette – Zostavila: HAJDÚ ANIKÓ, TéKa, 2016.
Lektorok – Recenzenti: Fedinec Csilla (MTA TK KI, Budapest) Fónagy Zoltán (MTA BTK TTI, Budapest) Gyáni Gábor (MTA BTK TTI, Budapest) Hornyák Árpád (MTA BTK TTI, Budapest) Miroslav Michela (Historický ústav SAV, Bratislava) Slávka Otčenášová (Katedra histórie UPJŠ, Košice) Szarka László (MTA BTK TTI, Budapest)
