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A Master Regulator of Oxidative StressThe Transcription Factor Nrf2
Due to that at present, the majority of diseases are associated with alterations in oxidative stress and inflammatory processes, and in that Nrf-2 is a modulator of these processes; knowing how this transcriptional factor functions and is regulated opens a therapeutic window to diverse diseases. Therefore, the efforts of various investigation groups are centered on finding activators and/or inhibitors of Nrf-2 to prevent or control diverse diseases, for example, cancer, where it would be important to regulate Nrf-2 in order for it to activate apoptosis pathways in cancerogenous cells, or in neurodegenerative diseases where cell death is predominant, it would be important for Nrf-2 to activate antiapoptotic pathways.
The Role of NRF2 Transcription Factor
The regulation of the transcription factor NRF2 opens a therapeutic window for a host of chronic degenerative diseases, such as diabetes and its complications, cancer, obesity, neurodegenerative diseases, kidney diseases, immunological diseases, and so on. The ability to regulate cytoprotective functions such as antioxidant defenses or pro-apoptotic or anti-apoptotic functions is of utmost importance. Currently, there are therapeutic agents to activate or inhibit NRF2; research should focus on understanding how NRF2 makes “the decision” to perform one function or another.
Advances in Natural Hazards and Hydrological Risks: Meeting the Challenge
This book gathers the proceedings of the 2nd International Workshop on Natural Hazards (NATHAZ'19), held in Lajes do Pico, Pico Island, Azores in 2019. Natural hazards constitute the threat of a naturally occurring event having a negative effect on human beings. These effects are often called natural disasters. Among the natural hazards and potential disasters to be considered are: earthquakes, volcanic eruptions, landslides, subsidence, floods, droughts and coastal erosion. In addition, there are anthropogenic hazards that occur as a result of human interactions with the environment. They include technological hazards, which occur due to exposure to hazardous substances in the environment. ...
Herbal Medicine Applications for Polycystic Ovarian Syndrome
Polycystic ovarian syndrome (PCOS) is a multifaceted reproductive, metabolic syndrome, and its symptoms involve interactions between hormones, genes, and environmental stressors. The characteristic symptoms of PCOS include menstrual abnormalities such as oligomenorrhea or amenorrhea. The general symptoms of PCOS are anovulation or oligo-ovulation. Herbal Medicine Applications for Polycystic Ovarian Syndrome provides comprehensive information on different aspects of PCOS, including its pathogenesis, symptoms, therapies, and management, particularly through herbal remedies. With 13 chapters related to different aspects of PCOS, this book provides enormous knowledge about the pathogenesis and r...
Reflections on Bioethics
The book Reflections on Bioethics is an effort that brings together works grouped into five sections: "Bioethics and Health", "Bioethics and Education", "Bioethics and Technology", "Bioethics in the Use of Experimental Animals",and "Selected Topics of Bioethics". In each of these sections, the fundamental concepts of bioethics and their relationship with each of these branches of knowledge are covered. The purpose is to give the reader a specific document of topics, it is not intended to be a treaty because the study of any of the five sections is very broad. However, this is an effort that manages to combine in interdisciplinary subjects that are fundamental for professionals of all fields of knowledge.
Annual Report
None
National Union Catalog
Includes entries for maps and atlases.
