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Anti-idiotype antibodies in cancer treatment
Actively induced immunotherapy is one of the most promising fields in cancer research and numerous approaches are being studied to design effective cancer vaccines. Among the treatment strategies to develop an effective immune response against tumor associated antigens is the use of anti idiotype (Ab2) mAb as antigen surrogates. Several studies in animal models have demonstrated the efficacy of these vaccines for triggering the immune system to induce specific and protective immunity against tumors of different origin. In fact, anti-idiotypic mAbs have been used successfully in cancer therapeutics to overcome the poor immunogenicity of some tumor-associated antigens, in particular those of non-protein origin. In some clinical trials, including patients with different tumors, anti-Id specific humoral and/or cellular responses following immunization were associated with improved clinical outcome. This number of Frontiers will be dedicated to anti- idiotypic antibodies and their use in cancer treatment. Different article types will be considered: original contributions, case reports, methods, hypothesis and theory, reviews, historical, etc.
Veracruz and the Caribbean in the Seventeenth Century
Explores how Veracruz's Afro-Mexican residents drew on Caribbean relationships to define a distinctive social and cultural community.
The Global Mind and the Rise of Civilization
How the global mind drives the evolution of both consciousness and civilization • Explains how our brains receive consciousness from the global mind, which upgrades human consciousness according to a pre-set divine time frame • Reveals how the Mayan Calendar provides a blueprint for these consciousness downloads throughout history • Examines the mind shift in humans and the development of pyramids and civilization in ancient Egypt, Sumer, South America, and Asia beginning in 3115 BCE In each culture the origins of civilization can be tied to the arising of one concept in the human mind: straight lines. Straight and perpendicular lines are not found in nature, so where did they come fro...
Companies and Entrepreneurs in the History of Spain
This book analyses the economic history of the company and entrepreneurship in Spain from the 15th century to the present. It evaluates the economic theory, the formation of the figure of the entrepreneur, as well as the structure of the companies. This exploration of the businessmen in Spain over several centuries is something that has not been done until now. Joining the great Spanish historiographical debate about the existence or not of entrepreneurship, the book brings together research in very different historical contexts and junctures. It presents a selection of cases of companies and entrepreneurs from Spain, from different sectors, regions and periods, from boom to crisis, from the wine businessman to the railway sector, from private banking to the pioneers of the Spanish travel agency business. It will be of interest to academics and students in economic history, business and management history, as well as researchers in entrepreneurship & small business management.
New Trends in English Teacher Education
Here is a collection of papers exploring fron an interdisciplinary standpoint recent developments in teaching English as a second language. Insights into teaching methodologies, language adquisition adn applied linguistics encompass the use of literature and cultural studies in educational research, in order to provide teachers and scholars with a state-of-the-art account of the current progresses in foreing language education.
Recursos humanos en investigación y desarrollo. Universidades y CSIC
Recursos humanos en investigación y desarrollo.--V.2.
Love and the Law in Cervantes
The consolidation of law and the development of legal writing during Spain's Golden Age not only helped that country become a modern state but also affected its great literature. In this fascinating book, Roberto Gonzalez Echevarria explores the works of Cervantes, showing how his representations of love were inspired by examples of human deviance and desire culled from legal discourse.
