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HPLC for Pharmaceutical Scientists
HPLC for Pharmaceutical Scientists is an excellent book for both novice and experienced pharmaceutical chemists who regularly use HPLC as an analytical tool to solve challenging problems in the pharmaceutical industry. It provides a unified approach to HPLC with an equal and balanced treatment of the theory and practice of HPLC in the pharmaceutical industry. In-depth discussion of retention processes, modern HPLC separation theory, properties of stationary phases and columns are well blended with the practical aspects of fast and effective method development and method validation. Practical and pragmatic approaches and actual examples of effective development of selective and rugged HPLC methods from a physico-chemical point of view are provided. This book elucidates the role of HPLC throughout the entire drug development process from drug candidate inception to marketed drug product and gives detailed specifics of HPLC application in each stage of drug development. The latest advancements and trends in hyphenated and specialized HPLC techniques (LC-MS, LC-NMR, Preparative HPLC, High temperature HPLC, high pressure liquid chromatography) are also discussed.
Marine Fisheries Ecology
This topical and exciting textbook describes fisheries exploitation, biology, conservation and management, and reflects many recent and important changes in fisheries science. These include growing concerns about the environmental impacts of fisheries, the role of ecological interactions in determining population dynamics, and the incorporation of uncertainty and precautionary principles into management advice. The book draws upon examples from tropical, temperate and polar environments, and provides readers with a broad understanding of the biological, economic and social aspects of fisheries ecology and the interplay between them. As well as covering 'classical' fisheries science, the book...
Generalized Additive Models
This book describes an array of power tools for data analysis that are based on nonparametric regression and smoothing techniques. These methods relax the linear assumption of many standard models and allow analysts to uncover structure in the data that might otherwise have been missed. While McCullagh and Nelder's Generalized Linear Models shows how to extend the usual linear methodology to cover analysis of a range of data types, Generalized Additive Models enhances this methodology even further by incorporating the flexibility of nonparametric regression. Clear prose, exercises in each chapter, and case studies enhance this popular text.
Practical HPLC Method Development
This revision brings the reader completely up to date on the evolving methods associated with increasingly more complex sample types analyzed using high-performance liquid chromatography, or HPLC. The book also incorporates updated discussions of many of the fundamental components of HPLC systems and practical issues associated with the use of this analytical method. This edition includes new or expanded treatments of sample preparation, computer assisted method development, as well as biochemical samples, and chiral separations.
Shaping Urban Infrastructures
Cities can only exist because of the highly developed systems which underlie them, ensuring that energy, clean water, etc. are moved efficiently from producer to user, and that waste is removed. The urgent need to make the way that these services are provided more environmentally, socially and economically sustainable means that these systems are in a state of transition; from centralized to decentralized energy; from passive to smart infrastructure; from toll-free to road pricing. Such transitions are widely studied in the context of the influence of service providers, users, and regulators. Until now, however, relatively little attention has been given to the growing role of intermediaries...
Once in a Promised Land
They say there was or there wasn't in olden times a story as old as life, as young as this moment, a story that is yours and is mine. Once in a Promised Land is the story of Jassim and Salwa, who left the deserts of their native Jordan for those of Arizona, each chasing mirages of opportunity and freedom. Although the couple live far from Ground Zero, they cannot escape the dust cloud of paranoia settling over the nation. A hydrologist, Jassim believes passionately in his mission to make water accessible to all people, but his work is threatened by an FBI witch hunt for domestic terrorists. A Palestinian now twice displaced, Salwa embraces the American dream. She grapples to put down roots in an unwelcoming climate, becoming pregnant against her husband's wishes. When Jassim kills a teenage boy in a terrible accident and Salwa becomes hopelessly entangled with a shadowy young American, their tenuous lives in exile and their fragile marriage begin to unravel. Once in a Promised Land is a dramatic and achingly honest look at what it means to straddle cultures, to be viewed with suspicion, and to struggle to find safe haven.
Structural Complexity Management
Product design is characterized by a steady increase in complexity. The main focus of this book is a structural approach on complexity management. This means, system structures are considered in order to address the challenge of complexity in all aspects of product design. Structures arise from the complex dependencies of system elements. Thus, the identification of system structures provides access to the understanding of system behavior in practical applications. The book presents a methodology that enables the analysis, control and optimization of complex structures, and the applicability of domain-spanning problems. The methodology allows significant improvements on handling system complexity by creating improved system understanding on the one hand and optimizing product design that is robust for system adaptations on the other hand. Developers can thereby enhance project coordination and improve communication between team members and as a result shorten development time. The practical application of the methodology is described by means of two detailed examples.
Disrupted Cities
Bringing together leading researchers from geography, political science, sociology, public policy and technology studies, Disrupted Cities exposes the politics of well-known disruptions such as devastation of New Orleans in 2005, the global SARS outbreak in 2002-3, and the great power collapse in the North Eastern US in 2003. But the book also excavates the politics of more hidden disruptions: the clogging of city sewers with fat; the day-to-day infrastructural collapses which dominate urban life in much of the global south; the deliberate devastation of urban infrastructure by state militaries; and the ways in which alleged threats of infrastructural disruption have been used to radically r...
Cities by Design
Who makes our cities, and what part do everyday users have in the design of cities? This book powerfully shows that city-making is a social process and examines the close relationship between the social and physical shaping of urban environments. With cities taking a growing share of the global population, urban forms and urban experience are crucial for understanding social injustice, economic inequality and environmental challenges. Current processes of urbanization too often contribute to intensifying these problems; cities, likewise, will be central to the solutions to such problems. Focusing on a range of cities in developed and developing contexts, Cities by Design highlights major aspects of contemporary urbanization: urban growth, density and sustainability; inequality, segregation and diversity; informality, environment and infrastructure. Offering keen insights into how the shaping of our cities is shaping our lives, Cities by Design provides a critical exploration of key issues and debates that will be invaluable to students and scholars in sociology and geography, environmental and urban studies, architecture, urban design and planning.
