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Molecular Function and Regulation of Non-coding RNAs in Multifactorial Diseases
Our understanding of the mechanisms underlying the development of multifactorial diseases such as diabetes, autism, Alzheimer's disease, and cancer has been greatly advanced. Non-coding RNAs (ncRNAs), generally including microRNAs and long non-coding RNAs, have recently been found to have potential roles in these diseases, and provide new opportunities for developing both specific biomarkers and therapeutic targets. However, the molecular function and regulation of these RNAs still remains challenging. Numerous studies are focusing on this field in order to fully appreciate the role and regulation of these molecules in human medicine and biology. This e-book aims to bring together new findings on Non-coding RNAs in different complex diseases. It will highlight the characterization, roles, mechanism, and mode of action of these RNAs in complex disorders. We believe that the publications on this topic would be exponentially extended in future. The improved approaches at multiple levels may pave the way for designing and applying new biomarker and therapeutic targets for specific diseases based on these attractive molecules.
From Nucleic Acids Sequences to Molecular Medicine
Despite a half century of structural, biophysical and biochemical investigations of ribonucleic acids, they are still mysterious. RNAs stand at fertile crossroads of disciplines, integrating concepts from genomics, proteomics, dynamics as well as biochemistry and molecular biology. From 20 years it is clear, that genetic regulation of eukaryotic organisms has been misunderstood for the last years that the expression of genetic information is effected only by proteins. Basic understanding of nucleic acids has enhanced our foundation to probe novel biological functions. This is especially evident for RNA molecules whose functionality, maturation, and regulation require formation of correct secondary structure through encoded base-pairing interactions.
Innovative Processing and Manufacturing of Advanced Ceramics and Composites
With continued discoveries and innovations, the field of materials synthesis and processing remains as it has been for many decades, a vibrant and fertile area for research and development. It comes, therefore, as no surprise that every Pac Rim conference has had considerable emphasis on this topic with many symposia devoted to various aspects of this field. This Ceramic Transactions volume represents selected papers based on presentations in four symposia during the 8th Pacific Rim Conference on Ceramic and Glass Technology, held in Vancouver, British Columbia, May 31-June 5, 2009.
Unsaturated Soils: Research and Applications
These volumes contain the contributions to the Second European Conference on Unsaturated Soils, E-UNSAT 2012, held in Napoli, Italy, in June 2012. The event is the second of a series of European conferences, and follows the first successful one, organised in Durham, UK, in 2008. The conference series is supported by Technical Committee 106 of the International Society of Soil Mechanics and Geotechnical Engineering on Unsaturated Soils. The published contributions were selected after a careful peer-review process. A collection of more than one hundred papers is included, addressing the three thematic areas experimental, including advances in testing techniques and soil behaviour, modelling, c...
Magnesium Technology 2014
The Magnesium Technology Symposium, the event on which this collection is based, is one of the largest yearly gatherings of magnesium specialists in the world. Papers represent all aspects of the field, ranging from primary production to applications to recycling. Moreover, papers explore everything from basic research findings to industrialization. Magnesium Technology 2014 covers a broad spectrum of current topics, including alloys and their properties; cast products and processing; wrought products and processing; forming, joining, and machining; corrosion and surface finishing; ecology; and structural applications. In addition, there is coverage of new and emerging applications in such areas as hydrogen storage. The collection includes more than 70 papers, including unpublished papers from the 2013 symposium.
Ancient and Traditional Foods, Plants, Herbs and Spices used in the Middle East
The use of different foods, herbs, and spices to treat or prevent disease has been recorded for thousands of years. Egyptian papyrus, hieroglyphics and ancient texts from the Middle East have described the cultivation and preparations of herbs and botanicals to “cure the sick.” There are even older records from China and India. Some ancient scripts describe the use of medicinal plants which have never been seen within European cultures. Indeed, all ancient civilizations have pictorial records of different foods, herbs, and spices being used for medical purposes. However, there are fundamental questions and issues pertaining to the scientific evidence for the use of these agents or their ...
Micro-Nano Technology XV
Selected, peer reviewed papers from the 15th Annual Conference and 4th International Conference of the Chinese Society of Micro-Nano Technology (CSMNT 2013), November 3-6, 2013, Tianjin, China
The Experiences and Challenges of Science and Ethics
In April 2002, the U.S. National Academies hosted an interacademy workshop involving participants from the United States and Iran on the topic of Science and Ethics. The explicit purposes of the workshop were (a) to engage important members of the American and Iranian scientific communities in meaningful discussions of the topic of science and ethics and particularly differences in the approaches in the west and in Islamic countries in general and Iran in particular, (b) to encourage greater participation by Iranian scientists in international scientific discussions by exposing them to seasoned veterans in international meetings, and (c) to identify specific topics and approaches that could be carried out by the Academies in the two countries to contribute to international understanding of the importance of considering the ethical dimensions of scientific research and related activities. This report includes documents prepared by four breakout groups and a statement on priority areas for future interacademy cooperation developed at the final plenary session. Also included are background papers prepared by some participants prior to the workshop that were not previously published.
Metagenomics and Microbial Ecology
Microorganisms comprise the greatest genetic diversity in the natural ecosystem, and characterization of these microbes is an essential step towards discovering novel products or understanding complex biological mechanisms. The advancement of metagenomics coupled with the introduction of high-throughput, cost-effective NGS technology has expanded the possibilities of microbial research in various biological systems. In addition to traditional culture and biochemical characteristics, omics approaches (metagenomics, metaproteomics, and metatranscriptomics) are useful for analyzing complete microbial communities and their functional attributes in various environments. Metagenomics and Microbial...
Phytoplasma Diseases of Major Crops, Trees, and Weeds
Phytoplasma Diseases of Major Crops, Trees, and Weeds is the second volume in a three-volume series dedicated to the analysis of plant pathogenic phytoplasmas across Asia. With a close look into the different types of plants affected by phytoplasma, the book offers management strategies to develop resistant plant strains. Phytoplasma diseases pose serious economic losses in many Asian countries, for which there is very little awareness within society. The chapters in Volume 2 comprehensively review predominant plant species and how they are impacted by phytoplasma diseases, providing information on host-pathogen interaction, characterization, and genetic diversity. The Phytoplasma Diseases i...
