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The most comprehensive and up-to-date allergy textbook in the world. Over 100 chapters written by world leading authorities covering virtually every aspect of basic and clinical allergy fully illustrated throughout with numerous overview diagrams and many colour illustrations. Authors contributing are from UK, Europe, North America and Australia.
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NATIONAL BESTSELLER *NOW A FOUR-PART CRAVE ORIGINAL DOCUSERIES* A top journalist crosses the yellow tape to investigate a shocking high-society crime. Billionaires, philanthropists, socialites . . . victims. Barry and Honey Sherman appeared to lead charmed lives. But the world was shocked in late 2017 when their bodies were found in a bizarre tableau in their elegant Toronto home. First described as murder-suicide — belts looped around their necks, they were found seated beside their basement swimming pool — police later ruled it a staged, targeted double murder. Nothing about the case made sense to friends of the founder of one of the world’s largest generic pharmaceutical firms and h...
Give Me One Good Reason is a tale of love, passion, and commitment, but yet there's betrayal, dishonesty, deception, and deceit. It gives you a twisted perception of a certain situation and then explodes into the unthinkable. But just when you think that all hope is gone, as we sometimes feel in life, there's a silver lining. That certain someone or something comes along and makes it all better. We can either accept certain situations, people, and things within our lives or we can let it go. We know that life isn't always as sweet as a bed of roses, but it doesn't have to be a bed of thorns either. Give Me One Good Reason is just that tale of failure to Faith. Life sometimes come with drama and dissatisfaction, but you don't have to deal with that and why would you want to. It's all about being happy and enjoying life to the fullest. Happiness starts with you and you only, other people may come along to enhance that happiness or add to it. Never let anyone determine your happiness, because they can be a part of your life one moment and decide to walk out the next.
This volume highlights the latest reviews of mechanisms and actions of the immune system and the host response to infection and inflammation.Key Features* Covers cytokine functioning as influenced by the Janus protein tyrosine kinase family* Explores immunodeficiencies, including:* Immunoglobulin deficiencies and B cells development* Glycosyl Phosphatidylinositol (GPI)-anchor and Paroxysmal Nocturnal Hemoglobinuria (PNH)* Investigates the links molecular pathology established between deficiencies in GPI-anchor synthesis and PNH* Includes the use of Multiple Antigen Peptides (MAPs) to induce protective immune response* Offers a timely update on Eosinophils' role in disease* Covers histology of Germinal center reaction of a spleen twelve days after primary immunization* Includes new research on cytotoxic T-lymphocytes* Presents the multiple roles of Nitric oxide (NO) in the inflammatory response
This state-of-the-art reference provides timely and clinically and experimentally useful information on the major proteins of mast cell secretory granules that are released into the lung, skin, gut, eye, and other tissues under the influence of diverse stimuli-including cytokines, growth factors, neuropeptides, and allergen-bound immunoglobulin E. Demonstrates the important roles proteases play in the maintenance of tissue homeostasis as well as in the damaging events linked with allergy and other varieties of inflammation!
The increasing incidence and prevalence of allergic disease worldwide is one of the most remarkable phenomena of the past 50 years. One in three people in developed countries will experience an allergic condition at some point in their lives and advances in understanding the causes of this trend, and in allergy treatment and care, have captured the imagination of scientists, clinicians and the public. Landmark Papers in Allergy is a definitive collection of over 90 papers charting key discoveries and scientific advances in relation to allergy and the development of treatment and care for allergic disorders. Comprehensive in its coverage, the book includes the first clear descriptions of alle...
This book provides a state-of-the-art account by academic respiratory physicians and senior pharmaceutical industry personnel on the development of new drugs for asthma, allergy and COPD. It contains 80 chapters of highly condensed information, presented in an attractive, reader-friendly format with much use of tables, figures and diagrams. In addition to summarizing the diverse range of current approaches, this handbook also looks into the future, considering many topics that are promising, but have only emerged in the last few years. Developments within established drug categories such as beta-2-agonists, steroids and leukotriene antagonists are also reviewed. Never before has a single book brought together so many pharmaceutical drug developers sharing their experience on such a wide range of respiratory topics!
Addressing the need for enhanced drug selectivity and efficacy, Biotherapeutic Approaches to Asthma is an authoritative and timely guide for respiratory specialists, clinical immunologists, allergists, physiologists, pulmonologists, otolaryngologists, and medical school students in these disciplines. It contains emerging data on the importance of c