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Skeletal Muscle Repair and Regeneration
Since the middle of the last century we have progressively built up a comprehensive descriptive model of the allied mechanisms that maintain our muscles at a size and strength appropriate to the functional demands upon them and that rapidly repair damaged muscles. This volume is an assemblage of the collective experience from the pick of major research groups investigating these aspects of muscle cell biology. It provides up-to-date coverage and presents a broad range of topics.
Craniofacial Muscles
Of the approximately 640 muscles in the human body, over 10% of them are found in the craniofacial region. The craniofacial muscles are involved in a number of crucial non-locomotor activities, and are critical to the most basic functions of life, including vision, taste, chewing and food manipulation, swallowing, respiration, speech, as well as regulating facial expression and controlling facial aperture patency. Despite their importance, the biology of these small skeletal muscles is relatively unexplored. Only recently have we begun to understand their unique embryonic development and the genes that control it and characteristic features that separate them from the skeletal muscle stereot...
Beyond the Neoliberal Creative City
A buoyant, creative economy can be seen as the saviour of many cities, but behind such 'urban makeovers' lie serious problems such as widening inequalities and gentrification. Blending lively city case studies with broader theoretical debates, this book explores the opportunities for a more just and sustainable urban future.
The Neuroendocrine Leydig Cells and their Stem Cell Progenitors, the Pericytes
cells, and the testicular localization of the intermediate filament protein nestin, known to be expressed in neural stem cells, by our group was the first step to define mural cells (pericytes and vascular smooth muscle cells) of the testis microvascu- ture as the stem/progenitor cells of the adult Leydig cells. In summary, we were able to demonstrate specific proliferation of vascular progenitors and their subsequent transdifferentiation into steroidogenic Leydig cells, which – in addition – rapidly acquire neuronal and glial properties. Since both newly developed fetal and adult Leydig cell populations show the same features, a common origin of both popu- tions seems likely. Pericytes ...
Advances In Tissue Engineering
Advances in Tissue Engineering is a unique volume and the first of its kind to bring together leading names in the field of tissue engineering and stem cell research. A relatively young science, tissue engineering can be seen in both scientific and sociological contexts and successes in the field are now leading to clinical reality. This book attempts to define the path from basic science to practical application. A contribution from the UK Stem Cell Bank and opinions of venture capitalists offer a variety of viewpoints, and exciting new areas of stem cell biology are highlighted. With over fifty stellar contributors, this book presents the most up-to-date information in this very topical and exciting field./a
Cancer and the Kidney
Cancer and the Kidney covers the challenging overlap area of nephrology and oncology, both in terms of kidney problems in cancer patients, and cancer that affects kidney patients, including assessment of kidney function, to paraneoplastic disorders, acquired cysts and native kidney cancers, and all points inbetween.
Stem Cells
This hugely important volume presents in a single text many novel aspects of stem cell biology with respect to scientific endeavors and future applications. During the past few years, stem cell research has metamorphosed into distinct and specialized avenues of research. What makes this book unique is that it not only covers these varied areas of research, but examines in detail some of the key pharmacological issues that up to now have not been addressed in a single volume.
Adult Neurogenesis
This is the first comprehensive, integrated account of one of the most exciting areas of neuroscience-the intersection between the discoveries that the adult brain makes new neurons and that it contains stem cells. The book begins with the historical background and discusses theories of adult neurogenesis and neural stem cell biology in the context of learning and memory processes as well as structural plasticity. It describes in detail neurogenesis in the adult hippocampus and olfactory system and then surveys the regulatory, functional, and comparative aspects, concluding with a chapter on the provocative hypotheses that link failing adult neurogenesis with such diseases as temporal lobe epilepsy, major depression, brain tumors, and dementias. This readable, single-authored volume is a unique resource for graduate students, investigators, and clinicians in the neurosciences, developmental biology, and stem cell research.
Adult Neurogenesis and Neural Stem Cells in Mammals
This title contains a book and CD. The brain has a number of nerve cells estimated at a magnitude of 10 to 100 billion, and 1014 to 1015 synapses, and therefore is the most complex organ of the human body. During fetal development the foundations of the brain are laid as billions of neurons form appropriate connections and patterns. In the adult mammalian brain, most neurons are post-mitotic, and therefore at risk for irreversible damage. As we age, atrophy of the brain occurs. As brain weight declines the volume of the brain in the 8th decade is reduced by 6 per cent -10 per cent versus the third decade, and neuronal loss occurs, up to 10,000 to 100,000 neurons are lost per day, though this estimation is being revised downward with the advance of more sophisticated measurements.
