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Transcriptional Control of Lineage Differentiation in Immune Cells
Insights into the regulation of immune cell lineage differentiation and specification as well as into the control of lineage integrity, stability and plasticity are of fundamental importance to understanding innate and adaptive immune responses. In this volume, leading experts provide an up-to-date and comprehensive overview of recent advances in the transcriptional control mechanisms and transcription factor networks that regulate these processes in a variety of different immune cell lineages. The chapters cover the regulation of T versus B cell lineage choice, discuss early B cell development and pre-B cell leukemia prevention, address transcriptional control mechanisms during the differen...
Arsenic in Drinking Water
The U.S. Environmental Protection Agency (EPA) has been considering a more stringent regulation of arsenic in water. A significant reduction in the maximum contaminant level (MCL) could increase compliance costs for water utilities. This book discusses the adequacy of the current EPA MCL for protecting human health in the context of stated EPA policy and provides an unbiased scientific basis for deriving the arsenic standard for drinking water and surface water. Arsenic in Drinking Water evaluates epidemiological data on the carcinogenic and noncarcinogenic health effects of arsenic exposure of Taiwanese populations and compares those effects with the effects of arsenic exposure demonstrated in other countriesincluding the United States. The book also reviews data on toxicokinetics, metabolism, and mechanism and mode of action of arsenic to ascertain how these data could assist in assessing human health risks from arsenic exposures. This volume recommends specific changes to improve the toxicity analyses and risk characterization. The implications of the changes for EPAs current MCL for arsenic are also described.
Heavy Metals In The Environment
This text presents contemporary analytical techniques for the determination of heavy metals in air particles, water, soil and biological samples. It details experimental studies to reduce the occurance of disease, remediate contaminated sites and establish acceptable range of oral intakes (AROI) guidelines.
Arsenic is Everywhere: Cause for Concern?
Exploring the presence of arsenic in our lives, from its occurrence in food to its use in medicine, this is a fascinating book for general readers.
Bone Marrow Failure
This book presents the latest scientific knowledge on inherited and acquired bone marrow failure syndromes, describing the advances in understanding of genetics and pathophysiology that have been achieved as a result of high-throughput DNA sequencing, RNA expression studies, and modern biochemistry techniques. The full range of relevant conditions is covered, including acquired aplastic anemia, Fanconi anemia, ribosomopathies, telomeropathies, dyskeratosis congenita, Shwachman-Diamond syndrome, Diamond-Blackfan anemia, and congenital neutropenias and thrombocytopenias. In addition, it is explained how the study of these rare diseases has uncovered important new science and elucidated the pathophysiology of more common hematological and oncological diseases. A treatment-specific chapter describes options ranging from the conventional to the cutting edge. Bone Marrow Failure will be of value for both trainee and practicing hematologists and oncologists.
Natural Killer Cells
Natural Killer Cells explains the importance of killer cells and how they are produced. It mentions that the most likely explanation for killer cell production is that they serve as a complementary system for T cells as a primary defense against viruses. However, these cells defend against certain viruses only, such as herpes viruses and influenza viruses. The book also explains the primary functions of killer cells, and it discusses how these cells help recognize damaged tissues, limit further damage to tissues, and regenerate damaged tissues. It discusses how these cells mature and develop, and it covers the different isolation, culture, and propagation methods of these cells. Furthermore,...
Thermoradiotherapy and Thermochemotherapy
Hyperthermia has been found to be of great benefit in combination with radiation therapy or chemotherapy in the management of patients with difficult and com plicated tumor problems. It has been demonstrated to increase the efficacy of ionizing radiation when used locally but also has been of help in combination with systemic chemotherapy where hyperthermia is carried out to the total body. Triple modality (thermo-chemo-radiotherapy) or other treatment combinations have not been fully evaluated and may demonstrate extended clinical applications in the future. Problems remain with regard to maximizing the effects of hyperthermia as they are influenced by a variety of external and intrinsic factors including bloodflow, microenvironment etc. While the previous volume has summarized more theoretical aspects of hyper thermia, i.e. biology, physiology and physics, the present volume compiles the current knowledge relative to the clinical applications of hyperthermia in combina tion with radiation therapy and/or chemotherapy, providing a comprehensive over view of its use in cancer management.
Cell Cycle Control
Addressing the regulation of the eukaryotic cell cycle, this book brings together experts to cover all aspects of the field, clearly and unambiguously, delineating what is commonly accepted in the field from the problems that remain unsolved. It will thus appeal to a large audience: basic and clinical scientists involved in the study of cell growth, differentiation, senescence, apoptosis, and cancer, as well as graduates and postgraduates.
