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Genomics, Proteomics, and Metabolomics
This book provides thorough coverage of high-throughput OMICs technologies for the monitoring of stem cells and regenerative medicine. Specific topics covered include the genomics, proteomics, and metabolomics aspects of regenerative medicine, metabolic profiling of mesenchymal stem cells, genome profiling of mesenchymal stem cells, OMICs monitoring of stem cell-derived exosomes, stem cell proteomics, lipidomics, OMICs profiling of cancer (stem) cells, and finally ethical considerations of OMICs-based investigations. Chapters are authored by world-renowned scientists who have valuable expertise in the field of OMICs and regenerative medicine. Genomics, Proteomics, and Metabolomics: Stem Cells Monitoring in Regenerative Medicine, part of Springer’s Stem Cell Biology and Regenerative Medicine series, is essential reading for researchers, clinicians, biologists, biochemists, and pharmaceutical experts conducting research in the fields of stem cell biology, molecular aspects of stem cell research, tissue engineering, regenerative medicine, cellular therapy, OMICs, bioinformatics, and ethics.
The Gallant Defender
On political conditions in Punjab, India, with particular reference to the role of Santa Jaranaila Siṅgha, 1947-1984, who died in Golden Temple (Amritsar) Assault.
Proceedings of the International Conference on Internet of Things, Communication and Intelligent Technology
This book includes original, peer-reviewed research papers from the International Conference on Internet of Things, Communication and Intelligent Technology (IoTCIT) 2022. It contains the application of communication and IoT engineering in the age of intelligent technology+ from the standpoint of disciplinary integration, combining theory and associated IoT and intelligent technology algorithms. The topics cover the full range of IoT solutions, from IoT to network security, and focus on many forms of communication, such as Next Generation (6G) Mobile Communication, D2D, and M2M Communication. Additionally, it examines Intelligent Technology, with a focus on Information System Modeling and Simulation. It also explores Cloud Computing, Pervasive and Mobile Computing, Distributed Computing, High Performance Computing, and Ubiquitous Computing.
Politics, Patronage and the Transmission of Knowledge in 13th - 15th Century Tabriz
In Politics, Patronage and the Transmission of Knowledge in 13th – 15th Century Tabriz, an international group of specialists from different disciplines investigate the role of Tabriz as one of the foremost centres of learning, cultural productivity, and politics in post-Mongol Iran and the Middle East. While standard accounts of Islamicate history have long presented the 13th to 15th centuries as the bottom of the decline paradigm of old, the present volume demonstrates the vibrancy and originality of the intellectual and cultural production of this period by focusing on Tabriz among other capitals of the region. The volume particularly explores the transmission of knowledge and institutional and cultural patronage in the post-Mongol period. Contributors include Reuven Amitai, Nourane Ben Azzouna, Sheila Blair, Devin DeWeese, Joachim Gierlichs, Birgitt Hoffmann, Domenico Ingenito, Robert Morrison, Ertuğrul Ökten, Judith Pfeiffer, Johannes Preiser-Kapeller, F. Jamil Ragep, and Patrick Wing.
Handbook of Mitochondrial Dysfunction
Mitochondria produce the chemical energy necessary for eukaryotic cell functions; hence mitochondria are an essential component of health, playing roles in both disease and aging. More than 80 human diseases and syndromes are associated with mitochondrial dysfunction; this book focuses upon diseases linked to these ubiquitous organelles. Accumulation of mitochondrial DNA damage results in mitochondrial dysfunction through two main pathways. Mutation in mitochondrial DNA causes diseases such as Kearns-Sayre syndrome and Pearson syndrome. Mutation in chromosomal DNA causes diseases such as Parkinson's disease and schizophrenia. These and many other diseases are reviewed in this book. Key Features Presents the detailed structure of mitochondria, mitochondrial function, roles of oxidants and antioxidants in mitochondrial dysfunction. Includes summary of both causes and effects of these diseases. Discusses current and potential future therapies for mitochondrial dysfunction diseases Explores a wide variety of diseases caused by dysfunctional mitochondria.
Clinical Bioenergetics
Clinical Bioenergetics: From Pathophysiology to Clinical Translation provides recent developments surrounding the etiology and pathophysiology of inherited and acquired energy-delated disorders. Across 40 chapters, world leaders in bioenergetics and mitochondrial medicine discuss novel methodologies designed to identify deficiencies in cellular bioenergetics, as well as the safety and efficacy of emerging management strategies to address poor cellular bioenergetics. Topics discussed include the omics landscape of impaired mitochondrial bioenergetics, hormones, tissue bioenergetics and metabolism in humans. Disease-specific case studies, modes of analysis in clinical bioenergetics, and therap...
Practical Approach to Mammalian Cell and Organ Culture
This Major Reference Work offers a detailed overview of culturing primary, secondary cell lines, tissues, and organs. It first introduces various types of mammalian cell cultures, infrastructure requirements for a mammalian cell-culture laboratory. The subsequent chapters present the detailed protocols for the isolation of mammalian hematologic organs and cells. It also discusses various cell-based assays for monitoring cell viability, cell proliferation, cytotoxicity, cell senescence, and cell death assays. In addition, the book addresses the various problems encountered while culturing animal cells, their possible causes, and suggested solutions, presenting detailed protocols for isolation and primary culturing of various mammalian cells and hematoimmunologic organs in two dimensions. Lastly, it reviews the various applications of animal-cell culture, stem-cell culture, and tissue and organ culture. As such, this reference book is highly relevant for students and professionals new to cell-culture work as well as to those wishing to expand their skills from cell-line cultures to primary cultures and from conventional 2D cultures to 3D cultures.
The Dynamic Nature of Mitochondria
Mitochondrial research has exploded over the last ~150 years. This book gives an amazing view on a conceptual change in our understanding of mitochondrial biology. It becomes clear that mitochondria are extremely dynamic in nature, controlling life at multiple levels. Mitochondria rule energy conversion, adapt cells well to changing stress and nutrient conditions, and regulate many cellular processes including immunity. The dynamic nature of mitochondria occurs at an intramitochondrial level but also includes its ability to interact with other organelles and to modulate multiple signalling pathways. It is thus not surprising that alterations or inabilities to ensure this dynamic behaviour is...
