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Shelf Life
'Shelf Life is whip-smart, slyly heartbreaking, and I felt the truth of it in my bones.’ Sophie Mackintosh, author of The Water Cure Ruth is thirty years old. She works as a nurse in a care home and her fiancé has just broken up with her. The only thing she has left of him is their shopping list for the upcoming week. Starting with six eggs, and working through spaghetti and strawberries, apples and tea bags, this inventive novel builds a picture of a woman defined by the people she serves; her patients, her friends, and, most of all, her partner of ten years. Without him, Ruth needs to find out – with conditioner and single cream and a lot of sugar – who she is when she stands alone. With her fresh unpredictable style, Franchini skewers modern relationships and toxic masculinity, moving effortlessly between humour and heartbreak to tell the story of a woman rebuilding herself on her own terms.
Retroviruses in Human Lymphoma/leukemia
In the Proceedings of this Symposium, papers are presented from leading laboratories worldwide studying human and animal retroviruses and their associated leukemias and other diseases, including AIDS. The volume provides an up-to-date review of the field and indicates possible future developments for cancer research in which multidisciplinary work, ranging from molecular biology to epidemiology, plays an important role. The book contains 31 papers which are grouped into the following subject areas: lectures; clinical aspects; epidemiology; virus transmission; characterization of viruses; infected cells; AIDS.
Comprehensive Medicinal Chemistry II
The first edition of Comprehensive Medicinal Chemistry was published in 1990 and was very well received. Comprehensive Medicinal Chemistry II is much more than a simple updating of the contents of the first edition. Completely revised and expanded, this new edition has been refocused to reflect the significant developments and changes over the past decade in genomics, proteomics, bioinformatics, combinatorial chemistry, high-throughput screening and pharmacology, and more. The content comprises the most up-to-date, authoritative and comprehensive reference text on contemporary medicinal chemistry and drug research, covering major therapeutic classes and targets, research strategy and organis...
Systems, Patterns and Data Engineering with Geometric Calculi
The intention of this collection agrees with the purposes of the homonymous mini-symposium (MS) at ICIAM-2019, which were to overview the essentials of geometric calculus (GC) formalism, to report on state-of-the-art applications showcasing its advantages and to explore the bearing of GC in novel approaches to deep learning. The first three contributions, which correspond to lectures at the MS, offer perspectives on recent advances in the application GC in the areas of robotics, molecular geometry, and medical imaging. The next three, especially invited, hone the expressiveness of GC in orientation measurements under different metrics, the treatment of contact elements, and the investigation...
Annual Report
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Use of Biomarkers in Assessing Health and Environmental Impacts of Chemical Pollutants
Biological markers (biomarkers) are useful tools for understanding the nature and extent of human exposure and risk from environmental toxicants. Biomarkers are classified into three basic categories: exposure, effect, or susceptibility. A marker of exposure is the product of the interaction between a target cell or molecule and a foreign substance (NAS, 1989). These markers can be used to determine the biologically effective dose necessary to elicit a particular physiological change in an organism. A marker of effect is a biochemical or physiological change in an organism that can predict the onset of adverse health effects resulting from a given exposure. Lastly, markers of susceptibility ...
Invertebrate Cytokines and the Phylogeny of Immunity
Based on the assumption that invertebrates as well as vertebrates possess factors regulating hematopoiesis, response to infection or wounding, studies dealing with the evolution of immunity have focused on the isolation and characterization of putative cytokine-related molecules from invertebrates. Until recently, most of our knowledge of cytokine- and cytokine receptor-like molecules in invertebrates has relied on functional assays and similarities at the physicochemical level. As such, a phylogenetic relationship between invertebrate cytokine-like molecules and invertebrate counterparts could not be convincingly demonstrated. In the present book, recent studies demonstrating cytokine-like activities and related signaling pathways in invertebrates are critically reviewed, focusing on findings from molecular biology and taking advantage of the completion of the genome from the fly Drosophila and the worm Caenorhabditis elegans.
Recombinant DNA Research and Viruses
The development of recombinant DNA technology has made a marked impact on molecular virology. The cleavage of viral DNA genomes with restriction enzymes and the cloning of such DNA fragments in bacterial p1asmids has led to the amplification of selected viral DNA fragments for sequencing and gene expression. RNA virus genomes which can be transcribed to their cDNA form were also cloned in bacterial p1asmids, facilitating the study of RNA virus genes. With the elucidation in recent years of the promoter sequence of various viral genes and the expression of these genes in bacteria or yeast, the understanding of many viral gene functions has made great progress. Cloning and expression of viral ...
Tubulo-Interstitial Nephropathies
Proceedings of the 4th Bari Seminar in Nephrology, April 25-28, 1990
District Heating and Cooling Networks
Conventional thermal power generating plants reject a large amount of energy every year. If this rejected heat were to be used through district heating networks, given prior energy valorisation, there would be a noticeable decrease in the amount of fossil fuels imported for heating. As a consequence, benefits would be experienced in the form of an increase in energy efficiency, an improvement in energy security, and a minimisation of emitted greenhouse gases. Given that heat demand is not expected to decrease significantly in the medium term, district heating networks show the greatest potential for the development of cogeneration. Due to their cost competitiveness, flexibility in terms of t...
