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Basic and Translational Applications of the Network Theory for Dystonia
A recently proposed novel scheme of dystonia suggests that it is a disorder of neural network. Impairment in any of the “nodes” of the network may result in deficient network activity, causing dystonia. This book aims to present various experimental evidence supporting the network theory of dystonia. Dystonia is the abnormal twisting and turning of the organ and associated involuntary oscillations. Although dystonia is less common than Parkinson’s disease, traumatic brain injury, or stroke, each of these common disorders present with dystonia. Information regarding the brain regions that may be involved in dystonia is surprisingly limited and often conflicting. With chapters written by subject matter experts, this is a unique title that focuses on dystonia as a network disorder. This book would be of interest to basic and clinical researchers with an interest in motor systems and movement disorders.
Eye Movements in the Critical Care Setting
This book describes the abnormal eye movements encountered in the critical care unit in everyday practice and elaborates on the mechanism and clinical significance behind them. Beginning with a thorough grounding of the basic anatomy and physiology ocular motor system and how they move the eyeballs; chapters explore the pathological descriptions of all the signs that a practicing neurologist, ophthalmologist, or emergency medicine specialist might see in other ICU's, as well as the diagnostic and prognostic evidence to answer the consult questions. Further chapters describe the abnormal ocular movements seen in the Neuro-ICU, Eye Movements in the Critical Care Setting is a comprehensive resource on eye movement in the critical care setting, and a useful guide for the neurologist, ophthalmologist, and emergency medical specialist and residents alike.
Advances in Translational Neuroscience of Eye Movement Disorders
A comprehensive book that reviews advances in ocular motor research on topics of general interest, rare, specialized or unique conditions, and pertinent basic neuroscience. A rare collection with contributions from basic neuroscientists, neurologists, and ophthalmologists. Includes dedicated chapters on mathematical models, pharmacotherapy, neuromodulation, motion perception, visual influence on eye movement, physiology of strabismus, and microsaccades. This book is dedicated to David Robinson - one of the pioneers of contemporary ocular motor and vestibular neuroscience.
The Neurology of Eye Movements
"lt is a tremendous achievement to have provided this highly comprehensive but readable text, which informs such a large group of researchers and clinicians." Christopher Kennard, PhD, FRCP, FMedSci, Professor of Clinical Neurology, Head, Nuffield Department of Clinical Neurosciences, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom. "A monograph written with deep knowledge, understanding, wisdom, clarity, intelligibility - the superlatives could go on and on... A remarkable achievement and a great gift to all of us from the two modern giants of eye movement disorders." Michael Halmagyi, MD, Eye and Ear Research Unit, Neurology Department, Royal Prince Alfred Hospital, The University of Sydney, Australia. "The fifth edition of The Neurology of Eye Movements is a must for all neurologists and neuroscientists interested in how the human vestibular and oculomotor systems adapt to movement in space and to optimally viewing the world and its contents." Louis R. Caplan, MD, Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.
Non-motor Parkinson's Disease
A comprehensive and practical manual describing the manifestations, pathophysiology and treatments for non-motor Parkinson's Disease. Topics covered in depth include autonomic and sexual dysfunction, mood disorders, sleep disturbances and drug-induced non-motor symptoms.
The New Visual Neurosciences
A comprehensive review of contemporary research in the vision sciences, reflecting the rapid advances of recent years. Visual science is the model system for neuroscience, its findings relevant to all other areas. This essential reference to contemporary visual neuroscience covers the extraordinary range of the field today, from molecules and cell assemblies to systems and therapies. It provides a state-of-the art companion to the earlier book The Visual Neurosciences (MIT Press, 2003). This volume covers the dramatic advances made in the last decade, offering new topics, new authors, and new chapters. The New Visual Neurosciences assembles groundbreaking research, written by international a...
Mechanisms and Emerging Therapies in Tremor Disorders
Tremor is intimately linked to the numerous interactions of the central and peripheral nervous system components tuning motor control, from the cerebral cortex up to the peripheral effectors. Activities of central generators, reflex loop delays, inertia, stiffness and damping are all factors influencing features of tremor. This book discusses the pathophysiology of tremor including membrane mechanisms and rodent models, the advances in genetics and the musculoskeletal models pertinent to body oscillations. The main forms of tremor encountered during clinical practice are considered, taking into account neuroimaging aspects. The book covers recent advances in methodologies and techniques of assessment, and provides practical informations for the daily management. In addition to pharmacological treatments, neurosurgical approaches such as deep brain stimulation (DBS) and thalamotomy are discussed. Emerging techniques under development are also introduced. Future challenges are also presented.
Models and Simulations of the Electric Field in Deep Brain Stimulation
Deep brain stimulation (DBS) is an established surgical therapy for movement disorders such as Parkinson’s disease (PD) and essential tremor (ET). A thin electrode is implanted in a predefined area of the brain with the use of stereotactic neurosurgery. In the last few years new DBS electrodes and systems have been developed with possibilities for using more parameters for control of the stimulation volume. In this thesis, simulations using the finite element method (FEM) have been developed and used for investigation of the electric field (EF) extension around different types of DBS lead designs (symmetric, steering) and stimulation modes (voltage, current). The electrode surrounding was ...
A Clinical Approach to Neuro-Ophthalmic Disorders
Neuro-ophthalmology is a merged subspecialty of neurology and ophthalmology dealing with complex multisystem diseases presenting with visual manifestations. This book helps the reader in recognizing, approaching, and managing such a patient. It covers the afferent and efferent systems, pupillary disorders, and Radiology of neuro-ophthalmic conditions. It features individual symptomatology with salient points, their management and differential diagnosis. It has case scenarios, key points, and algorithms along with self-assessment MCQ questions. Its simplified, step wise approach will be a useful resource for neurologists, ophthalmologists, physicians, pediatricians, and optometrists. Key Features • Features a simplified and stepwise clinical approach to neuro-ophthalmic disorders. • Includes case studies and clinical pearls along with self-assessment sections. • Covers to the point and crisp analysis of common complaints faced in neuro-ophthalmology. All the royalties of this book are donated to the Poor Patients Cell of PGIMER, Chandigarh.
