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Annual Report
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Pursuing the Origin of Pathogenic Bacterial Species
Microbes may become pathogenic and mankind develops antimicrobials and vaccines to fight with them, which may lead to an arms race as pathogens develop drug resistance and humans invent newer drugs, often ending up with uncontrollable infections. This book narrates the author’s journey pursuing the origin of pathogenic bacterial species, demonstrating through experiments that bacteria form new species by acquiring novel genes from surroundings and altering the genome for better fitness. If the newly acquired genes encode pathogenic traits, the originally benign bacteria may become new pathogens. To control pathogens, antimicrobials and vaccines are useful in many cases, but, in addition, book proposes a third strategy through the concept of herd resistance via enhancing the protective functions of intestinal microbiota, which will not trigger an arms race nor interfere with immune functions. This strategy can be generalized to a broad range of bacterial or viral pathogens, such as SARS-CoV-2.
Cell & Molecular Biology of Prostate Cancer
This volume covers classic and modern cell and molecular biology of prostate cancer, as well as novel biomarkers, inflammation, centrosome pathologies, microRNAs, cancer initiation novel biomarkers, inflammation, centrosome pathologies, microRNAs, cancer initiation and genetics, epigenetics, mitochondrial dysfunctions and apoptosis, cancer stem cells, angiogenesis and progression to metastasis, and treatment strategies including clinical trials related to prostate cancer. Cell & Molecular Biology of Prostate Cancer is one of two companion books comprehensively addressing the biology and clinical aspects of prostate cancer. Prostate Cancer: Molecular & Diagnostic Imaging and Treatment Stategies, the companion volume, discusses both classic and the most recent imaging approaches including analysis of needle biopsies, applications of nanoparticle probes and peptide-based radiopharmaceuticals for detection, early diagnosis and treatment of prostate cancer. Taken together, these volumes form one comprehensive and invaluable contribution to the literature.
Life Of Professor Robert Hugh Pritchard, The: The Rise Of Genetics At Leicester
Colleagues and former students of the late Professor Pritchard (aka Bob), an eminent UK geneticist, have gathered memories about his scientific and personal life. Bob's early, crucial contributions to decipher gene structure and mechanism of recombination in fungi, and those in bacterial physiology and the cell cycle, are briefly summarized. Bob was appointed as a young professor (34 years old) to open a new Department of Genetics at the University of Leicester, a department that thrived under his leadership to become internationally recognized for the quality of its scientific research and teaching. Pritchard's research studies on Microbial Genetics and Physiology and his intellectual leade...
Cell and Molecular Biology of Breast Cancer
Highlighting recent advances in our understanding of breast cancer, this book is intended for a wide audience as a reference book. Included are reviews of genetics, epigenetics, various aspects of cell and molecular biology, and several other areas of breast cancer that are aimed at determining new intervention sites for treatments and cures of the disease. The chapters are written by internationally recognized experts and include reviews of key topics in breast cancer research. Each chapter highlights the new aspects of specific research topics and the various impacts of designing new strategies as well as identifies new targets for therapeutic intervention. The topics addressed are selected to be of interest to patients, scientists, students, teachers, and anyone else interested in expanding their knowledge of breast cancer imaging, diagnostics, therapeutics, or basic biomedical research on breast cancer.
