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Actin
Actins are a highly conserved family of proteins found in virtually all eukaryotic cells. They have prolific roles in cell motility - from the contraction of striated muscle to the movement of organelles within cells, and are known to interact with a diverse number of proteins families from myosins to gelsolins. This up-to-date edition gives a comprehensive account of actin sequence, mutation and structure as well as providing insight into ligand-binding sites and drug and toxin binding. Illustrated throughout, this modern text also contains an extensive bibliography for the interested reader.
The Actin Cytoskeleton
Actin is one of the most abundant proteins and ubiquitously expressed in all eukaryotes. In recent years, the analysis of structure and function of such complexes has shed new light on actin's role in cellular and tissue morphogenesis, locomotion and various forms of intracellular motility, but also on its role in nuclear processes like chromatin architecture and transcription. Progress in understanding these different physiological phenomena, but also in unravelling the basis of actin-based pathophysiological processes has been made by combining video microscopy, molecular biology, genetics and biochemistry. Thus, the current research on actin, as ongoing in many international laboratories, is a "hot spot" in basic and translational research in life sciences. In this book on "The Actin Cytoskeleton", twelve internationally renowned authors present specific chapters that cover their recent work concerned with the various roles of actin mentioned above. This comprehensive volume is therefore an attractive handbook for teachers and students in many fields of medicine and pharmacology.
Actin
During the period August 5-9, 1992, and immediately preceding the 1992 Gordon Research Conference on Motile and Contractile Systems, the "Third International Conference on the Structure and Function of Ubiquitous Cellular Protein Actin" was held at the Emma Willard School in Troy, New York, under the title "ACTIN '92". This conference focused on the fundamental properties and cellular functions of actin and actin based microfilament systems. The first conference in this series was held in 1982, in Sydney, Australia, and hosted by Dr. Cristobal G. dos Remedios and Dr. Julian A. Barden, both from the University of Sydney (New South Wales, Austrailia). The second conference convened in Monza, I...
Actin-based Motility
Since the discovery of actin by Straub in the 1950’s and the pioneering work of Oosawa on actin self-assembly in helical laments in the 1960’s, many books and conference proceedings have been published. As one of the most essential p- teins in life, essential for movement in organisms rangingfrom bacteria to higher eukaryotes, it is no surprise that actin has fascinated generations of scientists from many different elds. Actin can be considered as a “living treasure” of biology; the kinetics and thermodynamics of self-assembly, the dissipative nature of actin po- merization, the molecular interactions of monomeric and polymerized actin with regulators, the mechanical properties of ac...
Molecular Interactions of Actin
Actin is one of the most widespread proteins in eukaryotic cells. This book and its companion ("Molecular Interactions of Actin. Actin Structure and Actin-Binding Proteins") provide an authoritative and opinionated view of the structure and function of this essential protein. Each section includes an historical perspective and a detailed commentary on actin protein chemistry, molecular and cell biology of actin. While some chapters review the body of knowledge of the subject, others contain new experimental data. This book will appeal to research scientists seeking contemporary overviews of actin-myosin interaction and actin-based regulation. Contributors include senior scientists as well as the new breed of younger scientists.
Actin-Monomer-Binding Proteins
This book provides a comprehensive view on actin monomer-binding proteins and the mechanisms by which they contribute to actin dynamics and various actin-dependent cellular processes. This new title contains chapters that describe the basic mechanisms of actin dynamics as well as the structural principles by which various actin-binding proteins interact with actin. The book is suitable further reading for students in advanced cell biology classes.
The Actin Cytoskeleton and Bacterial Infection
This volume describes the mechanisms which bacteria have created to secure their survival, proliferation and dissemination by subverting the actin cytoskeleton of host cells. Bacteria have developed a veritable arsenal of toxins, effector proteins and virulence factors that allow them to modify the properties of the intracellular actin cytoskeleton for their own purposes. Bacterial factors either modify actin directly as the main component of this part of the cytoskeleton or functionally subvert regulatory or signalling proteins terminating at the actin cytoskeleton. In short, this volume provides an overview of the various tricks bacteria have evolved to “act on actin” in order to hijack this essential host cell component for their own needs. As such, it will be of interest to scientists from many fields, as well as clinicians whose work involves infectious diseases.
Actin Polymerization in Apicomplexan
This book discusses in detail the structural, evolutionary and functional role of actin and its regulatory proteins in gliding motility in apicomplexan organisms, a unique phenomenon found in actin-myosin cytoskeletal elements. The book also explores the potential of different actin regulators, namely formin, profilin, actin depolymerization factor (ADF), capping proteins (CPα and CPβ), cyclase-associated protein (CAP) and coronin 13–24 as potential drug targets against malaria. As the chief components of the gliding motor, the actin-regulator proteins are characterized by unique features that make them promising targets for structure-based drug design. Lastly, the book proposes a mathematical model, based on kinetic data mining, to help understand the most vital regulators for actin polymerization dynamics.
Actin
Actin is a globular protein found in all eukaryotic cells and plays a central role in cell morphology, cell adhesions, cell contractility and motility, signal transduction, transcription and its regulation, cytokinesis and synapse formation, as well as malfunctioning of actin which can lead to various diseases. This book presents topical research in the study of the structure, functions and diseases related to actin. Topics discussed include actin dynamics and remodelling of cell-cell junctions in epithelial morphogenesis; osmotic pressure and the polymeric forms of actin; the molecular mechanisms of actin regulatory proteins and actin cytoskeleton alterations.
