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Role of Stem Cells in Skeletal Muscle Development, Regeneration, Repair, Aging and Disease
Adult stem cells are responsible for tissue regeneration and repair throughout life. Their quiescence or activation are tightly regulated by common signalling pathways that often recapitulate those happening during embryonic development, and thus it is important to understand their regulation not only in postnatal life, but also during foetal development. In this regard, skeletal muscle is an interesting tissue since it accounts for a large percentage of body mass (about 40%), it is highly amenable to intervention through exercise and it is also key in metabolic and physiological changes underlying frailty susceptibility in the elderly. While muscle-resident satellite cells are responsible f...
Praying to Portraits
In Praying to Portraits, art historian Adam Jasienski examines the history, meaning, and cultural significance of a crucial image type in the early modern Hispanic world: the sacred portrait. Across early modern Spain and Latin America, people prayed to portraits. They prayed to “true” effigies of saints, to simple portraits that were repainted as devotional objects, and even to images of living sitters depicted as holy figures. Jasienski places these difficult-to-classify image types within their historical context. He shows that rather than being harbingers of secular modernity and autonomous selfhood, portraits were privileged sites for mediating an individual’s relationship to the ...
Epigenetic Mechanisms in Neural Plasticity
Neural plasticity is a unique and adaptive feature of nervous system, which allows neurons to reorganize their interactions in response to a stimulation (intrinsic or extrinsic) to maintain their function. For these reasons, epigenetics emerges as a potential field for developing strategies to modulate changes in pathological situation because extrinsic factors and pharmacological tools can modify neural functioning in organisms during their life. Diet, exercise, environmental aspects, stressors or drugs are available to alter those mechanisms. Epigenetic involves certain molecular signaling pathways, as DNA methylation and histone acetylation and deacetylation, and the emerging non-coding s...
An Update on Neurological Disorders Post COVID-19 Infection
Coronavirus disease 2019 (COVID-19), produces the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), with atypical pneumonia. This infection is a global health challenge producing post-acute sequelae of SARS-CoV-2 infection (PASC), including neuro-PASC in which direct or indirect invasion of the virus into the brain causes immune dysregulation, hormonal disorders, elevated cytokine levels due to immune reaction and chronic inflammation, direct tissue injury, and persistent low-grade infection. The COVID-19 induced-neuroinflammation promotes blood-brain barrier (BBB) disruption, access of antigens and inflammatory factors into the brain, as well as infection or immune-mediated resp...
Recent Advances in Biomedical Signal Processing
"Biomedical signal processing is a rapidly expanding field with a wide range of applications, from the construction of artificial limbs and aids for disabilities to the development of sophisticated medical imaging systems. Acquisition and processing of bio"
Essentials of Cerebellum and Cerebellar Disorders
This monograph, now in its 2nd edition with 31 new chapters and significant updates, is the first book of its kind written specifically for graduate students and clinicians. The monograph is based on the 4-volume treatise, Handbook of the Cerebellum and Cerebellar Disorders (Springer, 2013; 2nd edition: 2022), the definitive reference for scientists and neurologists in the field of cerebellar neurobiology and related areas. There have been fundamental advances in the basic science and clinical neurology of the cerebellum and its role in sensorimotor function and cognition. Essentials of the Cerebellum and Cerebellar Disorders makes this large and expanding body of knowledge readily accessibl...
Muscle Cell and Tissue
In order to complete tissue regeneration, various cells (neuronal, skeletal and smooth) interact coordinately with each other. This book, Muscle Cell and Tissue - Current Status of Research Field, deals with current progress and perspectives in a variety of topics on the skeletal and smooth muscle, stem cells, regeneration, disease or therapeutics. Novel applications for cell and tissue engineering including cell therapy, tissue models and disease pathology modeling are introduced. This book also deals with the differentiation/de-differentiation process of vascular smooth muscle cells in health and disease. Furthermore, natural products to reverse metabolic syndromes are descriptively reviewed. These chapters can be interesting for graduate students, teachers, physicians, executives and researchers in the field of molecular biology and regenerative medicine.
Beyond Borders: Myotonic Dystrophies – A European Perception
Myotonic dystrophies (DMs) are pleotropic multisystemic diseases. These dominantly transmitted repeat disorders affect multiple organs of the human body at all ages – from the newborns to the elderly. The present Research Topic represents a timely addition to the expanding body of evidence which aims to provide novel perspectives in our understanding of myotonic dystrophies. This collection of original contributions and standpoint reviews from multiple leading DM centres in Europe describes the state of the art for the characterization of the DMs diseases, the development of molecular strategies to target its multisystemic nature, and provides evidence of screening and testing novel therapeutic avenues.
Sarcopenia
Sarcopenia: Molecular, Cellular, and Nutritional Aspects describes the progressive loss of skeletal muscle mass and strength, defined by Rosenberg in 1997 as a hallmark of aging and referred to as “sarcopenia.” As life expectancy continues to increase worldwide, sarcopenia has become a major public health issue. The condition worsens in the presence of chronic diseases accelerating its progression. Sarcopenia is not considered to be “a process of normative aging” but according to the International Classification of Disease, Tenth Revision, Clinical Modification (ICD-10-CM), as a disease. As sarcopenia is an ineluctable process, prevention and management are the only options to promot...
