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"Although it has been mooted whether the dramatic technological advances in neurological practice, (i.e., neuroimaging) might render the physical exam redundant, others maintain the central importance of neurological examination in patient management. A Dictionary of Neurological Signs seeks to elucidate the interpretation of neurological signs ("neurosemiology"): their anatomical, physiological, and pathological significance." (from the Preface) The structured entries in this practical, clinical resource provide a snapshot of a wide range of neurological signs. Each entry includes: definition of the sign; brief account of the clinical technique required to elicit the sign; description of the other signs which may accompany the index sign. Where known, the entries also include neuroanatomical basis of the sign; explanation of pathyophysiological and/or pharmacological background; neuropathological basis; differential diagnosis; and brief treatment details. The Dictionary provides practical, concise answers to complex clinical questions.
This revised and updated second edition provides a practical and structured overview of some of the most commonly used and easily available cognitive screening instruments applicable in the outpatient clinic and bedside setting. It now includes additional chapters on AD8 and also methodological aspects of systematic cognitive screening instrument assessment from the Cochrane Dementia and Cognitive Improvement Group. Expert authors from around the world equip the reader with clear instructions on the usage of each screening instrument, its strengths and weaknesses, and the time required for administration. Rules on scoring are also provided, such as how to correct for variations in the patient’s age or education, and suggested cut-off scores. Cognitive Screening Instruments: A Practical Approach, Second Edition is aimed at both clinicians and professionals in disciplines allied to medicine who are called upon to assess patients with possible cognitive disorders, including neurologists, old age psychiatrists, neuropsychologists, primary care physicians, dementia support workers, and members of memory assessment teams.
An essential reference text dealing with the neuropsychological features of neurological disorders.
The new and updated edition of this book explains the key steps in planning and executing diagnostic test accuracy studies in dementia, serving as an introduction to the topic with clear explanations of difficulties and pitfalls. It has been fully revised in light of developments over the past 5 years and includes STARD publications which have appeared since the first edition as well as the use of biomarkers of cognitive disorders as increasingly enshrined in diagnostic criteria. The book covers the presentation of study results in terms of measures of discrimination, taking examples from studies in dementia looking at various diagnostic methods including cognitive instruments, neuroimaging, and biochemical studies. The book continues to reflect the author’s own experience in diagnostic test accuracy studies, particularly in the sphere of cognitive screening instruments.. Diagnostic Test Accuracy Studies in Dementia encourages clinicians to adopt a pragmatic approach to diagnostic test accuracy studies rooted in day-to-day clinical practice.
Margiad wrote about the elderly, about love between women, about elusive, enigmatic characters. She is renowned for her ability to depict place, yet she also makes place reflective of the emotional and spiritual lives of her characters and her own concerns as an artist. Evans was a border writer, concerned with cultural complexity and conflict characteristic of borderlands, but also filled with passion for the landscape of the borders and the many meanings, local and figurative; she effortlessly invests in the places she loved. Her life was transformed in later years by epilepsy, followed by the diagnosis of a brain tumour that lead to her early death, on the evening of her forty-ninth birthday, in 1958. Evans wrote A Ray of Darkness, an acclaimed autobiography about her experience of epilepsy, and as a result Margiad Evans is being ‘rediscovered’ by the medical community as it becomes more interested in patient experiences. This collection of essays assesses Evans’s extraordinary literary legacy, from her use of folktale and the gothic to the influence of her epilepsy on her creative work.
This pioneering book explores in depth the role of neurotransmitters in conscious awareness. The central aim is to identify common neural denominators of conscious awareness, informed by the neurochemistry of natural, drug induced and pathological states of consciousness. Chemicals such as acetylcholine and dopamine, which bridge the synaptic gap between neurones, are the 'neurotransmitters in mind' that form the substance of the volume, which is essential reading for all who believe that unravelling mechanisms of consciousness must include these vital systems of the brain.Up-to-date information is provided on: Psychological domains of attention, motivation, memory, sleep and dreaming that define normal states of consciousness. Effects of chemicals that alter or abolish consciousness, including hallucinogens and anaesthetics. Disorders of the brain such as dementia, schizophrenia and depression considered from the novel perspective of the way these affect consciousness, and how this might relate to disturbances in neurotransmission. (Series B)
This book draws on the author’s experience in conducting pragmatic test accuracy studies on screening instruments for dementia/mild cognitive impairment. To facilitate comprehension and assimilation, all data is presented in an easily accessible, succinct and user-friendly way by means of a structured tabular format that allows tests to be easily compared. The pragmatic design of studies ensures high external validity and generalizability for the test results. The book includes a wealth of data on previously presented studies, as well as hitherto unreported test measures (“Number needed” metrics). It presents recently described and new diagnostic metrics (Likelihood to be diagnosed or misdiagnosed; Summary utility index; Number needed for screening utility); data from new studies on screeners (Attended with sign; Free-Cog; Two question depression screener; Jenkins Sleep Questionnaire; Triple test); and previously unpublished data (combination of SMC Likert and MACE; IADL Scale and MMSE). Given its scope, the book will be of interest to all professionals, beginners and seasoned experts alike, whose work involves the assessment of individuals with cognitive (memory) complaints.
The study of patients affected by disorders of the central nervous system is one of the crucial research methods for investigating the organization of cognitive functions in the brain. However, many clinicians remain unaware of the significant advances that have taken place in the field of cognitive neuroscience in the last decades. This book provides an introduction to the cognitive and behavioural aspects of the clinical practice of neurology. Most of the contributors to this book combine an active clinical practice with a leading role in their respective research area, and have provided concise summaries of the theoretical advances which they consider as potentially relevant for the clini...