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New Trends in Pharmacokinetics
The last decade or so has witnessed tremendous progress in methodology in the field of drug development in general and pharmacokinetics in particular. Clinical pharmacokinetics is using new tools for probing into the "black box" once being ac cessible only partly through experimental techniques and, mostly through mathemati cal and computer means. Development of computerized scanning, positron emission tomography (PET), stereoselectivity and other techniques are now enabling investi gators to have better pictures of the systems they are studying. Mathematical models through computer simulation and statistical estimation, mostly due to easy access be cause of inexpensive yet powerful personal...
Handbook of the Laboratory Diagnosis and Treatment of Infertility
This book provides comprehensive, detailed, and step-by-step descriptions of materials and methods currently used in laboratory procedures within the infertility clinic. It addresses the numerous highly sophisticated procedures resulting from research in the area of laboratory diagnosis and treatment of infertility. Among those procedures covered are:
Mechanisms in Fibre Carcinogenesis
The Editors are sorry that the production of this volume was delayed by the ill health of one of them and we hope that this does not detract from the value of the con tents. For once this delay is not the fault of any of the authors only the editors are to blame. Many of the workers in the field of fibre toxicology became convinced by the middle 1980's that the worst of the furore over asbestos was over although we were left with an intriguing problem - how does asbestos cause disease? It was expected that the future impact of fibres on human health would be very small since asbestos exposure would be controlled and there was little chance that man-made fibres would prove haz ardous. These m...
Drug Epidemiology and Post-Marketing Surveillance
This volume is a summary of material presented in the course given in the International School of Phannacology on "Drug Epidemiology and Post-Marketing Surveillance" between September 27 and October 8, 1990, at the "Ettore Majorana Center for Scientific Culture" in Erice, Sicily. The course, which was a NATO Advanced Study Institute, included lectures and workshops presented by experts in the new field of phannacoepidemiology. The material covered includes various approaches to spontaneous reporting of adverse drug reactions, including aggregate approaches, such as those used in France, and detailed analyses of individual reports, such as that done in The Netherlands and in Sweden. Also, inc...
Regulation of Choloroplast Biogenesis
From July 28 to August 3, 1991, an International Meeting on the REGULATION OF CHLOROPLAST BIOGENESIS was held at the capsis Beach Hotel in Aghia Pelaghia, on the island of crete, Greece. The Meeting (Advanced Research Workshop-Lecture Course) was co-sponsored by NATO, FEBS and IUB, and was held under the auspices of the International society for Chloro plast Development, the Greek Ministry of Industry, Research and Technol ogy, and the National Center for Scientific Research "Demokritos". The Meeting focused on recent advances in the field of chloroplast biogenesis and the regulatory mechanisms underlined, and brought together over 120 experts and students of the field from 22 countries. The...
Computational Aspects of the Study of Biological Macromolecules by Nuclear Magnetic Resonance Spectroscopy
This volume is the scientific chronicle of the NATO Advanced Research Workshop on Computational Aspects of the Study of Biological Macro molecules by Nuclear Magnetic Resonance Spectroscopy, which was held June 3-8, 1990 at Il Ciocco, near Barga, Italy. The use of computers in the study of biological macromolecules by NMR spectroscopy is ubiquitous. The applications are diverse, including data col lection, reduction, and analysis. Furthermore, their use is rapidly evolv ing, driven by the development of new experimental methods in NMR and molecular biology and by phenomenal increases in computational perfor mance available at reasonable cost. Computers no longer merely facilitate, but are now absolutely essential in the study of biological macromolecules by NMR, due to the size and complexity of the data sets that are obtained from modern experiments. The Workshop, and this proceedings volume, provide a snapshot of the uses of computers in the NMR of biomolecules. While by no means exhaustive, the picture that emerges illustrates both the· importance and the diversity of their application.
The Superfamily of ras-Related Genes
since the earliest results on the linkage between ras activation and cell transformation appeared a vast amount of additional information has been generated which emphasizes the importance of ras-related genes in membrane trafficking, cell proliferation, differentiation and cancer. These advances led to the development of new strategies for the diagnosis, prognosis and prevention of cancer. Ras-related genes appear to be central to the mechanism of transformation by other oncogenes and therefore constitute a focal point upon which attempts to intervene in the process of carcinogenesis will be concentrated. The present volume contains the contributions to the NATO Advanced Research Workshop o...
Developmental Neuropathology of Schizophrenia
This volume reports the proceedings of a NATO Advanced Workshop held in Castelvecchio Pas coli, Italy, from August 28 - September 1, 1989. An important inspiration for this Workshop came from our studies in Helsinki and Denmark, which have found that exposure to an influenza epidemic during the second trimester of fetal development increases the risk of adult schizophrenia. This finding has stimulated an important new hypothesis in the study of the etiology of schizophrenia. It has suggested the possiblity that disturbances of brain development during gestation may contribute to the risk of adult schizophrenia. We determined that it would be of value to bring together schizophrenia researche...
Pharmaceutical Applications of Cell and Tissue Culture to Drug Transport
In recent years there have been rapid advances in the growth and differentiation of mammalian cells in culture. This has led to increasing use of such in vitro systems in a wide variety of studies on fundamental aspects of cell structure and function, including normal growth and metabolism, mechanisms of differentiation and oncogenesis, mechanisms of protein and membrane synthesis and cell polarity. Recent advances in our ability to grow cells, including human cells, on permeable supports, to generate confluent cellular barriers with the morphological polarity corresponding to their in vivo counterparts has greatly facilitated such studies. In particular these new techniques have led to an i...
The Changing Visual System
In late May and early June 1991, a NATO Advanced Study Institute was held at a hotel in the hilltop village of San Martino al Cimino a few kilometers from the city of Viterbo in the Lazio region of Italy. The title of the course was the same as this volume and brought together specialists working at all phases of the life span (embryology, infancy, childhood, middle life and senescence) in both animals and humans to exchange ideas, facts and theories in the search for common principles. Such principles could prove important for understanding developmental changes in the central nervous system and visual behavior within the context of a continuum of life-span processes rather than viewing them as events or mechanisms that occur only in a certain period. For example, changes that are associated with "aging" were considered as extensions or continuations of processes that began at an earlier stage of the life span, rather than being seen as processes that only began late in life.
