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This book describes in detail the clinical presentation, diagnosis, and management of a wide range of congenital bleeding disorders. It will assist readers in overcoming the significant challenges involved in clinical and laboratory diagnosis and in providing effective clinical care that makes optimal use of new products, including recombinant factor concentrate. The coverage ranges from hemophilia A and B and von Willebrand disease to rare bleeding disorders such as congenital factor V, factor X, factor XI, and factor XIII deficiency and inherited platelet function disorders. The exceptional attention to rarer conditions is of particular importance given the considerable risk of overlooking them during diagnosis, with potential consequences for disease-related morbidity and mortality. The authors are acknowledged specialists in the field from across the world who have particular expertise in the disorder that they discuss. The book will be of value to hematologists, oncologists, pediatricians, laboratory specialists and technicians, general physicians, and trainees.
Surgical Intensive Care Medicine has been specifically designed to be a practical reference for medical students and house officers to help manage the critically ill surgical patient. The first section is titled “Resuscitation” and exposes the reader to a condensed version of generic topics in primary intensive care medicine. The sections that follow have been categorized according to medical and surgical subspecialties and cover the most germane of problems encountered in a tertiary surgical intensive care unit. Sections of certain chapters, while repetitive, have been left intact in an attempt to maintain the authors' messages and provide the reader with some contradictory but referenced views. The technical chapters describe a very introductory approach to various exercises such as airway management and vascular cannulation.
This significantly updated new edition describes in detail the clinical presentations, diagnosis, and management of a wide range of congenital bleeding disorders. It will assist readers in overcoming the significant challenges involved in clinical and laboratory diagnosis and in providing effective clinical care that makes optimal use of new products, including recombinant factor concentrate. The coverage ranges from hemophilia A and B and von Willebrand disease to rare bleeding disorders such as congenital factor V, factor X, factor XI, and factor XIII deficiency and inherited platelet function disorders. The exceptional attention to rarer conditions is of particular importance given the considerable risk of overlooking them during diagnosis, with potential consequences for disease-related morbidity and mortality. The authors are acknowledged specialists in the field from across the world who have particular expertise in the disorder that they discuss. The book will be of value to hematologists, oncologists, pediatricians, laboratory specialists and technicians, general physicians, and trainees.
This book discusses the current and future impact of cellular and molecular medicine (CMM) on anesthesiology and perioperative medicine. It covers the topic from a translational perspective and describes the relevance of CMM to daily clinical practice. Taking a bench-to-bedside approach, chapters examine topics including perioperative acute and chronic management, perioperative organ protection, and novel pharmaceuticals. Personalized Medicine in Anesthesia, Pain and Perioperative Medicine is aimed at anesthesiologists and pain physicians, and will also be of interest to pharmacists and those working in cellular and molecular medicine.
Coagulation disorders can have a variety of causes and may lead to either an increased risk of excessive bleeding or an increased risk of thromboembolic events. Both types of coagulation disorders can be life-threatening and require immediate therapy. Major bleeding is often triggered by an acute cause, such as severe trauma or peripartum hemorrhage (PPH) . The high rate of pre-existing intake of anticoagulants, such as DOACS or Vitamin-K antagonists, can also induce or even aggravate bleeding events, for example in cerebral hemorrhage or traumatic brain injury (TBI). Hereditary causes, such as the congenital Factor XIII deficiency or hemophilia, can also trigger a clinically relevant hemorrhage however, hereditary coagulation disorders are more often associated with thromboembolic events.
This book will help registrars develop their learning for the FRCP part 1 exam which all haematology trainees are required to pass during training. The exam is a two-paper exam with multiple choice questions as well as essays. There are over 100+ guidelines for registrars to learn and this book has all of them in one place described in a succinct manner.There are also multiple gaps and other areas of learning which the guidelines do not cover. Each page of this book accurately summarises a topic in the style of how you would approach an essay. The tips within the book on good ways to approach the exam from the author's own personal experience.
The only up-to-date definitive reference source onhemophilia This book is an invaluable resource that provides an overview ofall aspects of the care of patients with haemophilia. Covering how to assess both bleeding children and adults,Haemophilia A and B, molecular basis of the disease, the role offactors in coagulation, epidemiology, pharmacokinetics, andtreatment of inhibitors. There will also be a section onmusculoskeletal aspects of haemophilia as well as newerdevelopments such as gene therapy and rare bleedingdisorders. Textbook of Hemophilia is ideal for: Trainees and residents in hematology Hematologists in practice Specialists working in thrombosis and hemostasis as well astransfusion medicine Why Buy This Book? The only up-to-date definitive reference source onhemophilia Essential for all those managing hemophilia patients Detailed guidance on assessment, diagnosis, management andtreatment Advice for everyday clinical questions Edited by three of the world’s leading experts onhemophilia
Thrombohemostatic disorder is a common haematological problem. This book focuses on the "thrombohemostatic disorder" in several aspects including summative data from the molecular to the population scales, as well as additional metanalysis for important topics.
This collection thoroughly explores the dynamic and ever-developing field of hemostasis and thrombosis diagnostics and research. After an introductory section covering the basics and preanalytical issues, the book continues with in-depth sections that explore how to get the best outcomes from routine coagulation and specialized hemostasis assays, thrombophilia-related techniques, investigations into bleeding disorders, as well as performance of global assays of hemostasis, and finally post-analytical issues in hemostasis and thrombosis testing. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Comprehensive and practical, Hemostasis and Thrombosis: Methods and Protocols serves as an ideal resource for researchers and diagnostic laboratories seeking expert guidance and working to identify the best methodologies to pursue hemostasis and thrombosis testing.
Presents a modern vision of anaesthesia, integrating technology and knowledge, to change how anaesthesia is taught and practised.