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A groundbreaking medical and social history of a devastating hereditary neurological disorder once demonized as “the witchcraft disease” When Phebe Hedges, a woman in East Hampton, New York, walked into the sea in 1806, she made visible the historical experience of a family affected by the dreaded disorder of movement, mind, and mood her neighbors called St.Vitus's dance. Doctors later spoke of Huntington’s chorea, and today it is known as Huntington's disease. This book is the first history of Huntington’s in America. Starting with the life of Phebe Hedges, Alice Wexler uses Huntington’s as a lens to explore the changing meanings of heredity, disability, stigma, and medical knowle...
Written by 30 authors from all over the world, this book provides a unique overview of exciting discoveries and surprising developments in human genetics over the last 50 years. The individual contributions, based on seven international workshops on the history of human genetics, cover a diverse range of topics, including the early years of the discipline, gene mapping and diagnostics. Further, they discuss the status quo of human genetics in different countries and highlight the value of genetic counseling as an important subfield of medical genetics.
"In the early 1800s, a century before there was any concept of the gene, physicians in insane asylums began to record causes of madness in their admission books. Almost from the beginning, they pointed to heredity as the most important of these causes. As doctors and state officials steadily lost faith in the capacity of asylum care to stem the terrible increase of insanity, they began emphasizing the need to curb the reproduction of the insane. They became obsessed with identifying weak or tainted families and anticipating the outcomes of their marriages. Genetics in the Madhouse is the untold story of how the collection and sorting of hereditary data in mental hospitals, schools for 'feebl...
A root-and-branch rethinking of how history has shaped the science of genetics. In 1900, almost no one had heard of Gregor Mendel. Ten years later, he was famous as the father of a new science of heredity—genetics. Even today, Mendelian ideas serve as a standard point of entry for learning about genes. The message students receive is plain: the twenty-first century owes an enlightened understanding of how biological inheritance really works to the persistence of an intellectual inheritance that traces back to Mendel’s garden. Disputed Inheritance turns that message on its head. As Gregory Radick shows, Mendelian ideas became foundational not because they match reality—little in nature ...
Conceived at a time when biological research on aggression and violence was drawn into controversy because of sociopolitical questions about its study, this volume provides an up-to-date account of recent biological studies performed -- mostly on humans. A group of scientists recognized the importance of freedom of inquiry and deemed it vital to address the most promising biological research in the field. The focus on biological mechanisms is not meant to imply that biological variables are paramount as a determinant of violence. Rather, biological variables operate in conjunction with other variables contributing to aggression or violence, and a complete understanding of this phenomenon req...
Designed for students, young managers and seasoned practitioners alike, this handbook explains the nuts and bolts of the modern logistics and distribution world in plain language. Illustrated throughout, this second edition includes new chapters on areas previously not covered, such as: intermodal transport; benchmarking; environmental matters; and vehicle and depot security.
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From reviews of the hardback:'It is timely to see such an excellent textbook... Aimed at graduate level students, this book is complex enough to be thorough, but clear with enough background to be accessible... the coverage is comprehensive and the flow logical... The text is uniformly well written and achieves a successful integration.' -The Lancet'A good introduction and reference book for professionals interested in psychiatric genetics such as psychiatrists, clinical psychologists and neuroscientists... the book you want to have on your bookshelf to look up material and obtain a complete and balanced picture of the field.' -Psychological MedicineRevised for paperback edition, with new ap...
While fraud is generally associated with the business world, this book demonstrates that there is also a good deal of fraud and deception among scientists, writers and philanthropists. Scientists will sometimes announce fraudulent findings in order to raise money for additional research projects. Since many scientists live by this "soft" money and have no other income, the temptation to claim results that never occurred is great. Likewise, authors and journalists may commit fraud by claiming that they saw some thing that they did not see or that an event occurred which never happened. There are also writers who steal the work of others and publish such material under their own name. There ar...
With our success in mapping the human genome, the possibility of altering our genetic futures has given rise to difficult ethical questions. Although opponents of genetic manipulation frequently raise the specter of eugenics, our contemporary debates about bioethics often take place in a historical vacuum. In fact, American religious leaders raised similarly challenging ethical questions in the first half of the twentieth century. Preaching Eugenics tells how Protestant, Catholic, and Jewish leaders confronted and, in many cases, enthusiastically embraced eugenics-a movement that embodied progressive attitudes about modern science at the time. Christine Rosen argues that religious leaders pu...