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Clinical and Molecular Aspects of Neurotropic Virus Infection
In the summer of 1984, both of us were working with Professor Yechiel Becker in the Laboratory for Molecular Virology at the Hebrew University-Hadassah Medical center in Jerusalem. During a discussion about the increasing number of specialized journals and monographs, Dr. Becker pointed out that none covered both the clinical and molecular aspects of neurotropic virus infections, and he urged us to develop such a book with the help of colleagues who were conducting highly-regarded research in their individual areas related to neurotropic viruses. The responses to our request were gratifying, and each contribution provided both a comprehensive clinical description of the neurologic disease pr...
Neurobehavioral Toxicity
In establishing how certain chemicals can cause behavioural disorders, the process of neurotoxicity risk assessment poses significant challenges to every discipline within neuroscience. In this volume, leaders from industrial, academic, and government settings share insights on behavioural measurement in neurotoxicity risk assessment, and address the critical scientific issues arising from the expanding role of neurobehavioral toxicology in public policy development.; The authors set out to provide a comprehensive and authoritative review of current methods in the analysis and interpretation of neurobehavioural toxicology. Coverage begins with a discussion of criteria for determining neurotoxic potential. The next section examines neurobehavioural evaluations in developmental neurotoxicity. Subsequent sections focus on activity and observational data and applications of schedule-controlled operant behaviour in toxicity testing. The contributors address controversies surrounding the suitability and interpretation of procedures designed for neurotoxicological assessments. Some case studies are also included.
Chromosome Segregation and Aneuploidy
Proceedings of the NATO Advanced Research Workshop on Chromosome Segregation and Aneuploidy, held at Aghia Pelagia, Greece, October 10-15, 1992
Modern Analysis of Antibodies
This book brings together an up-to-date account of instructions in the chemical and biological methods of analysis for antibiotics. It is helpful for all scientific workers in the diversified community of industrial, medical, academic, and governmental antibiotic laboratories.
Nutrition and Gene Expression
Nutrition and Gene Expression is devoted to exploring the tissue-specific and developmental aspects of the interaction between nutrients and the genome. The book discusses chemical sensitivity in relation to the ability of cells to detect nutrients; reviews the means by which lower organisms respond to nutrients; and provides examples on how each of the classes of nutrients affects genetic transcription, mRNA translation or stability. The receptor-mediated actions of vitamin D and retinoic acid on gene expression are discussed, including the case of bone formation and dissolution. Other important topics covered in the volume include newly discovered effects of fatty acids on regulating gene expression, the effects of diet on mRNA editing, the interplay between dietary carbohydrates and proteins in regulating metabolism of liver cells, the effects of metal ions on protein synthesis, and much more. Nutrition and Gene Expression is an important reference for nutritionists, physiologists, biochemists, clinical nutritionists, pharmaceutical researchers, geneticists, and food scientists.
The Effects of Aging and Environment on Vision
This book derives from a symposium conducted in San Francisco CA, entitled "Environmental Design for Optimum Vision in the Elderly" that was sponsored by the American Aging Association, October 11-12, 1985. Presentations from this symposium comprise the core content of this volume. However, manuscripts have also been accepted from additional authors whose topics and research findings increase the scope and goals of this volume. Previously unpublished data is found in several of the chapters. In addition new data and references have been incorporated at the end of chapters in order to provide a current update of the subject. The broad aims of the papers in this volume were to examine the effe...
Combination Therapy in Urological Malignancy
Any discussion of the present success in management of urological cancers evokes a mixed response. Oncologists and urologists can enjoy the success with chemotherapy for testicular cancers but cannot forget the dismal results with any form of treatment, other than surgery, for renal carcinoma. But these are the less frequent urolegi cal tumours: what are the attitudes to the more common prostate and bladder cancers. Intensive study, many clinical trials and much debate lead us to the conclusion that we understand them better, we can tailor the treatment more appropriately to the individual patient but there remains some uncertainty as to the overall success that we have achieved. There have ...
The Membrane Hypothesis of Aging
The Membrane Hypothesis of Aging offers the most comprehensive, multidisciplinary description of the cell maturation and aging process. The membrane hypothesis of aging (MHA) described in this book is based on the actual multidisciplinary knowledge of cell morphology, physiology, and biochemistry. The solid basis of known facts explains the destructive, progressive, intrinsic, and universal character of the aging process. The book interprets other aging theories, including free radical theory of aging, dysdifferentiation hypothesis of aging and cancer, and the accumulation theories. It presents important issues for future research. The book also outlines the possibilities of an efficient, preventive, anti-aging drug design, and presents the first promising results of such research activity.
