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This comprehensive volume discusses approaches for a systematic selection of delivery systems for various classes of therapeutic agents including small molecule, protein, and nucleic acid drugs. Specific topics covered in this book include: Solution, suspension, gel, nanoparticle, microparticle, and implant dosage forms Refillable and microneedle devices Intravitreal, suprachoroidal, intrascleral, transscleral, systemic, and topical routes of delivery Physical methods including iontophoresis for drug delivery Rational selection of routes of administration and delivery systems Noninvasive and continuous drug monitoring Regulatory path to drug product development Clinical endpoints for drug pr...
This issue of Psychiatric Clinics of North America, edited by Drs. Frank Yeomans and Kenneth Levy, will offer a comprehensive review of key topics of importance in the study of Borderline Personality Disorder. The series is led by our Consulting Editor, Dr. Harsh Trivedi of Sheppard Pratt Health System. This issue will explore the following topics: Conceptual models, Diagnosis and assessment, Differential diagnosis, Community and Clinical Epidemiology, Comorbidity, Longitudinal Course, Neuroscience and social cognition, Attachment, Psychotherapy and medication treatment research, Psychotherapy with children and adolescents, and Family and patient perspectives, among others.
Transference-Focused Psychotherapy for Adolescents With Severe Personality Disorders is a manual for clinicians who wish to learn an effective psychodynamic treatment for young people with personality disorders (PDs). Despite converging evidence that PDs emerge in childhood and are clearly evident in adolescence, research on effective treatments has been limited. The editors have therefore created a book that details treatment models with strong theoretical foundations and examines systematic interventions designed to explore and resolve the conflicts and behaviors, common to PDs, that impede normal adolescent development. The book begins with an overview of psychopathology and normal adoles...
This book provides a comprehensive, in-depth review of our current understanding of the growth of blood vessels within the eye. Novel therapeutic strategies for the treatment of ocular angiogenesis are discussed, as are the unique challenges presented by delivery of drugs to the eye. The book emphasizes basic principles rather than specific experimental results, although recently acquired data is frequently cited to illustrate points of broader theoretical significance.
Attachment abuse can involve both physical and emotional violence between people in close relationships, which includes couples, parents and their children, and adult children and their aging parents, among others. Attachment abusers blame their victims for their own feelings of shame, inadequacy, or inability to love. Dr. Stosny's innovative and integrative approach to the treatment of attachment abuse emphasizes the importance of compassion for both the abused and the abuser. This hands-on manual provides a series of treatment modules designed to teach the perpetrators and the victims how to cope with their feelings and to end attachment abuse. This volume will be of interest to psychotherapists, group therapists, social workers, and counselors working with abusive clients and their victims.
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Decision making is a key activity, perhaps the most important activity, in the practice of healthcare. Although physicians acquire a great deal of knowledge and specialised skills during their training and through their practice, it is in the exercise of clinical judgement and its application to individual patients that the outstanding physician is distinguished. This has become even more relevant as patients become increasingly welcomed as partners in a shared decision making process. This book translates the research and theory from the science of decision making into clinically useful tools and principles that can be applied by clinicians in the field. It considers issues of patient goals, uncertainty, judgement, choice, development of new information, and family and social concerns in healthcare. It helps to demystify decision theory by emphasizing concepts and clinical cases over mathematics and computation.
This volume breaks new ground in the understanding and treatment of couples' abuse. It expands the models of abusive relationships to include the special concerns of gay couples, mutually violent partners, abusive women, and others.
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