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The City Record
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Material-based Mechanobiology
Mechanobiology is a new research field that investigates how the physical forces and changes in mechanical properties of cells and tissues contribute to their development, physiology and disease. One unique feature in the mechanical regulation, distinct from chemical/biochemical one, is that it can directly react with the multi-layered architectures of living systems, ranging from nano-scale proteins, subcellular organelles, cells, tissues, organs to whole bodies; one could term it “mechanoarchitectonics”. Another important aspect is its time-dependent dynamic feature. Not only time evolution in cells and extracellular matrices, but their intrinsic viscoelastic nature makes mechanical in...
Amyotrophic Lateral Sclerosis
A flurry of recent research on the role of the RNA/DNA-binding proteins TDP-43 and FUS as well as a dozen other factors (e.g., C9ORF72 and profilin) has led to a new paradigm in our understanding of the pathobiology of the motor neuron disease, Amyotrophic Lateral Sclerosis (ALS). How these factors trigger neuromuscular dysfunction is critical for developing more effective ALS therapeutics. The ‘gain-of-toxicity’ or ‘loss-of-function’ of these etiological factors is a key question. Recent studies on the imbalance in genome damage versus repair have opened avenues for potential DNA repair-based therapeutics. This book highlights emerging science in the area of ALS and discusses key approaches and mechanisms essential for developing a cure for ALS.
Congressional Record
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From Ship's Cook to Baronet
Sir William Reardon Smith (1856-1935) was one of the foremost figures in south Wales in the early twentieth century. His was a classic story of ‘rags to riches’ - starting life as a deck-hand and ship’s cook sailing from his native Appledore in 1870, he was a master mariner at the age of twenty-two and subsequently commanded many of the fine sailing ships owned by Hugh Hogarth & Sons of Glasgow. A long-cherished ambition to become a shipowner was eventually realised in 1906 when he acquired his first steamship, City of Cardiff. The venture prospered and nine vessels were owned on the eve of the First World War. He subsequently showed great entrepreneurial initiative during the depressi...
