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Metabolism Meets Function: Untangling the Cross-Talk Between Signalling and Metabolism
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
REDOX PROTEOMICS & BIOINFORMATICS
The studies in this book demonstrated that increased oxidative stress in brain play a significant role in age-related cognitive impairment. Moreover, such increased oxidative stress leads to specific protein oxidation in the brain of cognitive impaired subject, thereby leading to cognitive function impairment. Moreover, the functional alterations of the proteins identified by proteomics in this book may leads to impaired metabolism, decline antioxidant system, and damaged synaptic communication. Ultimately, impairment of these processes lead to neuronal damages and cognitive decline. This book also show that several of the up- regulated and oxidized proteins in the brains of normal aging mice identified are known to be oxidized in neurodegenerative diseases as well, suggesting that the expression levels of certain proteins may increase as a compensatory response to oxidative stress. This compensation would allow for the maintenance of proper molecular functions in normal aging brains and protection against neurodegeneration.
Methods in Biological Oxidative Stress
Oxidative damage appears to play a central role in the development of a wide range of tissue pathology, including neurodegenerative disease, drug side-effects, xenobiotic toxicity, carcinogenesis, and the aging process, to name just a few. Because of the centrality of oxidative processes to normal and abnormal tissue function, it has become imperative to develop appropriate analytical techniques to facilitate the quantitation of significant reactants. Without advances in methodology, corresponding advances in our knowledge of underlying biochemical events will be necessarily limited. Drs. Hensley and Floyd have done an outstanding job of assembling the work of world-class experts into Method...
Role of Metabolism in Regulating Immune Cell Fate Decisions
We acknowledge the initiation and support of this Research Topic by the International Union of Immunological Societies (IUIS). We hereby state publicly that the IUIS has had no editorial input in articles included in this Research Topic, thus ensuring that all aspects of this Research Topic are evaluated objectively, unbiased by any specific policy or opinion of the IUIS.
Ways of Nature
In Ways of Nature, Dr. Décossard articulates the first theory of evolution since Darwin. By his own account, he stumbled upon his proposed mechanism of eukaryogenesis using a process worthy of the three princes of Serendip. From there, he succeeded in establishing a comprehensive theory of life and the universe. For instance, we learn that a new paradigm, called “ the seeds-first theory,” explains biodiversity among eukaryotic species, such as those of plants and animals. It is interesting to discover what contributions, if any, the theory of natural selection provided to the new model. Nevertheless, the modern version of Darwinism, or neo-Darwinism, has long been engaged in a major ant...
Directory of Graduate Research
Faculties, publications and doctoral theses in departments or divisions of chemistry, chemical engineering, biochemistry and pharmaceutical and/or medicinal chemistry at universities in the United States and Canada.
