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Statistics for Innovation
4. 1. 1 ImportanceofComputerSimulation The importance of experimenting for quality improvement and innovation of pr- ucts and processes is now very well known: “experimenting” means to implement signi?cant and intentional changes with the aim of obtaining useful information. In particular, the majority of industrial experiments have two goals: • To quantify the dependence of one or more observable response variables on a group of input factors in the design or the manufacturing of a product, in order to forecast the behavior of the system in a reliable way. • To identify the level settings for the inputs (design parameters) that are capable of optimizing the response. The set of rule...
mODa 9 – Advances in Model-Oriented Design and Analysis
Statisticians and experimentalists will find the latest trends in optimal experimental design research. Some papers are pioneering contributions, leading to new open research problems. It is a colection of peer reviewed papers.
Cancer Clinical Trials
Cancer Clinical Trials: Current and Controversial Issues in Design and Analysis provides statisticians with an understanding of the critical challenges currently encountered in oncology trials. Well-known statisticians from academic institutions, regulatory and government agencies (such as the U.S. FDA and National Cancer Institute), and the pharmaceutical industry share their extensive experiences in cancer clinical trials and present examples taken from actual trials. The book covers topics that are often perplexing and sometimes controversial in cancer clinical trials. Most of the issues addressed are also important for clinical trials in other settings. After discussing general topics, the book focuses on aspects of early and late phase clinical trials. It also explores personalized medicine, including biomarker-based clinical trials, adaptive clinical trial designs, and dynamic treatment regimes.
Swarm Intelligence
These proceedings contain the papers presented at ANTS 2010, the 7th Int- national Conference on Swarm Intelligence, organized by IRIDIA, CoDE, U- versitéLibre de Bruxelles,Brussels, Belgium, during September 8–10,2010.The ANTS series started in 1998 with the First International Workshop on Ant Colony Optimization (ANTS 1998), which attracted more than 50 participants. Since then ANTS, which is held bi-annually, has gradually become an inter- tional forum for researchers in the wider ?eld of swarm intelligence. In the past (since 2004), this development has been acknowledged by the inclusion of the term“SwarmIntelligence” (nextto“AntColonyOptimization”)intheconference title. This ...
Randomization in Clinical Trials
Praise for the First Edition “All medical statisticians involved in clinical trials should read this book...” - Controlled Clinical Trials Featuring a unique combination of the applied aspects of randomization in clinical trials with a nonparametric approach to inference, Randomization in Clinical Trials: Theory and Practice, Second Edition is the go-to guide for biostatisticians and pharmaceutical industry statisticians. Randomization in Clinical Trials: Theory and Practice, Second Edition features: Discussions on current philosophies, controversies, and new developments in the increasingly important role of randomization techniques in clinical trials A new chapter on covariate-adaptive...
Repeated Measures Design with Generalized Linear Mixed Models for Randomized Controlled Trials
Repeated Measures Design with Generalized Linear Mixed Models for Randomized Controlled Trials is the first book focused on the application of generalized linear mixed models and its related models in the statistical design and analysis of repeated measures from randomized controlled trials. The author introduces a new repeated measures design called S:T design combined with mixed models as a practical and useful framework of parallel group RCT design because of easy handling of missing data and sample size reduction. The book emphasizes practical, rather than theoretical, aspects of statistical analyses and the interpretation of results. It includes chapters in which the author describes some old-fashioned analysis designs that have been in the literature and compares the results with those obtained from the corresponding mixed models. The book will be of interest to biostatisticians, researchers, and graduate students in the medical and health sciences who are involved in clinical trials. Author Website:Data sets and programs used in the book are available at http://www.medstat.jp/downloadrepeatedcrc.html
Optimal Design and Related Areas in Optimization and Statistics
The present volume is a collective monograph devoted to applications of the optimal design theory in optimization and statistics. The chapters re?ect the topics discussed at the workshop “W-Optimum Design and Related Statistical Issues” that took place in Juan-les-Pins, France, in May 2005. The title of the workshop was chosen as a light-hearted celebration of the work of Henry Wynn. It was supported by the Laboratoire I3S (CNRS/Universit ́ e de Nice, Sophia Antipolis), to which Henry is a frequent visitor. The topics covered partly re?ect the wide spectrum of Henry’s research - terests. Algorithms for constructing optimal designs are discussed in Chap. 1, where Henry’s contribution...
Adaptive Designs for Sequential Treatment Allocation
Adaptive Designs for Sequential Treatment Allocation presents a rigorous theoretical treatment of the results and mathematical foundation of adaptive design theory. The book focuses on designing sequential randomized experiments to compare two or more treatments incorporating information accrued along the way. The authors first introduce the terminology and statistical models most commonly used in comparative experiments. They then illustrate biased coin and urn designs that only take into account past treatment allocations as well as designs that use past data, such as sequential maximum likelihood and various types of doubly adaptive designs. The book also covers multipurpose adaptive experiments involving utilitarian choices and ethical issues. It ends with adaptive methods that include covariates in the design. The appendices present basic tools of optimal design theory and address Bayesian adaptive designs. This book helps readers fully understand the theoretical properties behind various adaptive designs. Readers are then equipped to choose the best design for their experiment.
