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Precision Medicine in Oncology
The emerging precision medicine approach aims to tailor disease prevention and treatment to each patient on the basis of individual variability, environmental factors and lifestyle. Fundamental achievements in the last few decades have converged to offer nowadays the compelling opportunity to move towards this innovative approach: i) unprecedented improvements in disease modeling in silico, in vitro and in vivo; ii) acquisition of a wide range of biomedical information combined with the development of computational toolsets for flexible and integrative analyses of multi-assay datasets. Our deeper understanding of oncogenic mechanisms has finally begun to have a crucial impact on clinical decisions at several steps, from cancer prevention and diagnosis to therapeutic intervention. However, precision oncology still encounters several unresolved hurdles including tumour heterogeneity and recurrence as well as unexplained drug resistance and lack of effective ways to monitor response to therapeutic treatments. Notably, limitations in biomedical research regulation and governance represent additional debatable issues that need careful consideration.
Protein Interaction Networks in Health and Disease
The identification and mapping of protein-protein interactions (PPIs) is a major goal in systems biology. Experimental data are currently produced in large scale using a variety of high-throughput assays in yeast or mammalian systems. Analysis of these data using computational tools leads to the construction of large protein interaction networks, which help researchers identify novel protein functions. However, our current view of protein interaction networks is still limited and there is an active field of research trying to further develop this concept to include important processes: the topology of interactions and their changes in real time, the effects of competition for binding to the ...
Leaves of Grass - Foglie d'erba
NON DISPONIBILE PER KINDLE E-INK, PAPERWHITE, OASIS. Pubblicata per la prima volta nel 1855 e arricchita nelle numerose edizioni successive, Foglie d’erba è una raccolta poetica che ha avuto un impatto dirompente sulla scena letteraria del tempo. Nuovo lo stile, quasi un flusso in versi liberi, nuova la cornice visionaria in cui si annullano i confini tra “io” e “mondo”. Un viaggio da fare.
Poesie d'amore
None
Multi-omic Data Integration
Stable, predictive biomarkers and interpretable disease signatures are seen as a significant step towards personalized medicine. In this perspective, integration of multi-omic data coming from genomics, transcriptomics, glycomics, proteomics, metabolomics is a powerful strategy to reconstruct and analyse complex multi-dimensional interactions, enabling deeper mechanistic and medical insight. At the same time, there is a rising concern that much of such different omic data –although often publicly and freely available- lie in databases and repositories underutilised or not used at all. Issues coming from lack of standardisation and shared biological identities are also well-known. From thes...
Kierkegaard's International Reception
As Kierkegaard's reputation grew, he was co-opted by a number of different philosophical and religious movements in different contexts throughout the world. This volume features the three tomes that attempt to record the history of this reception according to national and linguistic categories.
The Reception of S. T. Coleridge in Europe
A collection of research on the European reception of Samuel Taylor Coleridge (1772-1834), the major Romantic poet and author of "The Ancient Mariner" one of the best known poems in British literature.
Tutte le poesie
Introduzione di Gianni Nicoletti Cura e traduzione di Laura Mazza Testo francese a fronte La poesia di Rimbaud raggiunge vertici di straordinaria bellezza. Il poeta «malato», «criminale», «maledetto», si rivela in questi versi un grande «veggente» che trae dal profondo la propria voce, attraverso un programmatico «sregolamento» di tutti i sensi e la trascrive in un linguaggio dai significati stravolti. Riversa così nella scrittura una carica aggressiva che spezza lo schema metrico e sconvolge la lingua nobile della migliore tradizione letteraria, contaminandola con il lessico delle bettole per scandalizzare il lettore «borghese». Prende corpo così la figura di un ribelle incant...
Computational Methods in Systems Biology
This book constitutes the refereed proceedings of the International Conference on Computational Methods in Systems Biology, CMSB 2006, held in Trento, Italy, in October 2006. The 22 fully revised papers presented together with 2 invited talks were carefully reviewed and selected from 68 submissions. The papers present a variety of techniques from computer sciences, such as language design, concurrency theory, software engineering, and formal methods.
