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Methods in Membrane Lipids
This book presents a compendium of methodologies for the study of membrane lipids, varying from traditional lab bench experimentation to computer simulation and theoretical models. The volume provides a comprehensive set of techniques for studying membrane lipids with a strong biophysical emphasis. It compares the various available techniques including the pros and cons as seen by the experts.
BK Channels: Integrators of Cellular Signals in Health and Disease
Maxi calcium-activated potassium channels (BK) are an amazing category of ion channels which are found in cellular plasma membranes as well as in membranes of intracellular organelles. The function of these channels is to repolarize any excited membrane by passing a potassium outward current, in response to depolarization and/or increase in local calcium levels. Thus, voltage and calcium ions are involved in gating the channel under physiological conditions. This dual activation makes them perfect sensors for many cellular events that require integration between intracellular calcium levels and electrical signals. A plethora of physiological and pathophysiological functions, such as membrane...
The Neuropharmacology of Alcohol
This volume gives an overview of new insights to alcohol pharmacology using DREADDs (Designer Receptors and Unraveling the Neuropharmacology of Alcohol). It examines which pharmacological principles should be applied to understanding DREADDs taking into account some very current research. Additionally, this book covers important topics under the heading of “experimental pharmacology” and alcohol.
Vascular Ion Channels in Physiology and Disease
Ion channels are the major class of membrane proteins responsible for rapid and regulated transport of ions across biological membranes and for the generation and propagation of electrical signals in the brain, heart, and skeletal and vascular tissues. Ion channels are also known to play critical roles in regulation of cell proliferation, insulin secretion and intracellular signaling in a variety of cell types. This book focuses on the roles of ion channels in vascular tissues under normal and pathological conditions. Vascular abnormalities are known to underlie a plethora of severe pathological conditions, such as atherosclerosis, systemic and pulmonary hypertension, coronary or cerebral vasospasm, and diabetes. In addition, misregulated angiogenesis is one of the major contributors to the development of tumors. Therefore, it is clearly imperative to obtain a better understanding of the molecular mechanisms that contribute to vascular disorders. This book will be the first comprehensive assembly of assays to present the studies that have been done during the last decade to elucidate the roles of ion channels in different vascular diseases.
Cholesterol Modulation of Protein Function
In this book, renowned scientists describe the role of steroid chirality and modification of lipid membrane physical properties in the modulation of G protein-coupled receptors and ion channels. The application of commonly-used technical approaches such as mass spectrometry and nucleic magnetic resonance transfer spectroscopy for studies on cholesterol distribution and alteration of lipid bilayer characteristics is also discussed. This book offers comprehensive insights into the current understanding of cholesterol-driven modulation of protein function via mechanisms that extend beyond lipid-protein direct interactions. In the first part, the chapters introduce the reader to the use of the c...
Cholesterol Regulation of Ion Channels and Receptors
Examines new research on the role of cholesterol in regulating ion channels and receptors and its effect on health Drawing together and analyzing all the latest research findings, this book explores the role of cholesterol in the regulation of ion channels and receptors, including its pathological effects. It is the first book to comprehensively describe the complex mechanisms by which cholesterol regulates two major classes of membrane proteins. Moreover, it sheds new light on how cholesterol affects essential cellular functions such as the contraction of the heart, propagation of nerve impulses, and regulation of blood pressure and kidney function. Written and edited by leading pioneers in...
Cholesterol and PI(4,5)P2 in Vital Biological Functions
Cholesterol is an essential component of the plasma membrane. Phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), although a minor phospholipid, is the most abundant membrane phosphoinositide. Both lipids play key roles in a variety of cellular functions including as signalling molecules and major regulators of protein function. Studies on these important lipids have traditionally focused on the effect of each lipid individually. Accumulating evidence indicates, however, that these lipids may cross-regulate each other’s levels. Furthermore, it is becoming evident that cholesterol and PI(4,5)P2 can act together to modulate protein function and biological processes. This book provides an over...
Recent Advances in Cannabinoid Physiology and Pathology
The cannabinoid system plays a central role in a wide variety of physiological functions that touch upon cardiovascular, gastrointestinal, immune, and nervous systems. Cannabinoids also play a central role in developmental physiology, management of pain, and shaping of human behaviour. Recent movements towards legalization of marijuana use have bolstered scientific interest in the cannabinoid field and led to research efforts that would unveil multi-faceted effects and mechanisms of cannabinoid presence in different organs and at various stages of development. This book summarizes the recent advances in the field of cannabinoid research at multiple levels of resolution. It spans from systemic effects of cannabinoids on development, physiological function, and prevalent pathophysiological conditions to mechanisms that govern cannabinoid interaction with their relevant protein targets at atomic resolution. This book will be of interest to a specialized audience in the fields of biochemistry, pharmacology and developmental biology but alsoto a wider readership with interest in general physiology and cannabinoid signalling in biological systems.
New Techniques for Studying Biomembranes
New Techniques for Studying Biomembranes describes some of the latest methods used to investigate the dynamic distribution of specific lipids in membranes and their effects on other membrane components. The contributors present important discoveries with respect to lipid analysis and lipid interactions with membrane proteins. Various methods, which have been used to study lipid bilayer structure and lipid organization in membranes, include both in vitro and in vivo membrane systems, and study membrane proteins in various membrane systems. Key Features: Reviews both in vivo and in vitro analytical technologies and methods for studying membrane structure and function Explores how lipid bilayer...
Sterol Regulation of Ion Channels
Sterol Regulation of Ion Channels, Volume 80, the latest in the Current Topics in Membranes series provides outstanding content to the scientific community on relevant topics that relate to the broad field of membranes. Topics of note in this new release include Membrane structure and general mechanisms of sterol regulation of ion channels, the Regulation of ion channels by sterols as boundary lipids, the Differential effects of sterols on ion channels: specific vs. non-specific interactions, the Structural determinants of cholesterol-ion channels interactions, and the Regulation of Ca2+-sensitive K+ channels by cholesterol and bile acids via distinct channel subunits and sites, amongst othe...
