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First multi-year cumulation covers six years: 1965-70.
First multi-year cumulation covers six years: 1965-70.
The epidemiological and clinical importance of bone metastasis has long been recognized, but the past decade has seen an explosion in the fields of bone biology and bone cancer research. This period of time has been marked by a number of key discoveries that have led to the opening up of entirely new areas for investigation as well as new therapies which combine surgery and biological therapeutic approaches.Bone is a common site of cancer metastases - cancer cells commonly develop in bone and spread to other organ systems through the bloodstream. For example, the incidence of bone metastases in breast and prostate cancers is 70%, whereas it is only 30 to 40% in metastatic lung cancer. In cli...
Melanoma is a disease entity that has the capability of involving all organ systems of the human body. During the last decade a dramatic increase in the incidence of this disease has been noted. It is surpassed in this dreadful statistic only by carcinoma of the lung. During this time frame, much has been defined and written concerning the histopathology and prognostic fac tors of this neoplastic disorder. The relative ease of maintaining this malig nant cell in tissue culture has permitted the cellular biologist, tumor immu nologist, immunochemist and geneticist an ideal in vitro experimental mod el for advancing our understanding of human malignancy. Histopathologic features, prognostic fa...
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