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Challenges in Endocrine Disruptor Toxicology and Risk Assessment
Insight into the role of hormones, particularly estrogen and testosterone, in health and disease etiology - including interactions with other hormone pathways - has dramatically changed. Estrogen and androgen receptors, with their polymorphisms, are key molecules in all tissues and are involved in a number of homeostatic mechanisms but also pathological processes including carcinogenesis and the development of metabolic and neurological disorders such as diabetes and Alzheimer's disease. Endocrine disrupting chemicals (EDCs) can interfere with the endocrine (hormone) systems at certain dosages and play a key role in the pathology of disease. Most known EDCs are manmade and are therefore an i...
Recycling of Used Lead-Acid Batteries
This document includes a pragmatic framework for designing representative studies and developing uniform sampling guidelines to support estimates of morbidity that are explicitly linked to exposure to land-based contaminants from used lead acid battery recycling (ULAB) activities. A primary goal is to support environmental burden of disease evaluations, which attempt to attribute health outcomes to specific sources of pollution. The guidelines provide recommendations on the most appropriate and cost-effective sampling and analysis methods to ensure the collection of representative population-level data, sample size recommendations for each contaminant and environmental media, biological samp...
Artisanal Small-Scale Gold Mining
This framework document provides a pragmatic approach for designing representative studies and developing uniform sampling guidelines to support estimates of morbidity that are explicitly linked to exposure to land-based contaminants from small-scale artisanal gold mining activities. A primary goal is to support environmental burden of disease evaluations, which attempt to attribute health outcomes to specific sources of pollution. The guidelines provide recommendations on the most appropriate and cost-effective sampling and analysis methods to ensure the collection of representative population-level data, sample size recommendations for each contaminant and environmental media, biological s...
Challenges in Endocrine Disruptor Toxicology and Risk Assessment
Insight into the role of hormones, particularly estrogen and testosterone, in health and disease etiology – including interactions with other hormone pathways – has dramatically changed. Estrogen and androgen receptors, with their polymorphisms, are key molecules in all tissues and are involved in a number of homeostatic mechanisms but also pathological processes including carcinogenesis and the development of metabolic and neurological disorders such as diabetes and Alzheimer’s disease. Endocrine disrupting chemicals (EDCs) can interfere with the endocrine (hormone) systems at certain dosages and play a key role in the pathology of disease. Most known EDCs are manmade and are therefor...
Biscriptality
Serbs write their language in Cyrillic or Latin letters in seemingly random distribution. Hindi-Urdu is written in Nagari by Hindus and in the Arabic script by Muslims. In medieval Scandinavia the Latin alphabet, ink and parchment were used for texts 'for eternity', whereas ephemeral messages were carved into wood in runes. The Occitan language has two competing orthographies. German texts were set either in blackletter or in roman type between 1749 and 1941. In Ancient Egypt the distribution of hieroglyphs, hieratic and demotic was much more complex than commonly assumed. Chinese is written with traditional and simplified characters in different countries. This collective monograph, which includes contributions from eleven specialists in different philological areas, for the first time develops a coherent typological model on the basis of sociolinguistic and graphematic criteria to describe and classify these and many other linguistic situations in which two or more writing systems are used simultaneously for one and the same language.
Roberto Caracciolo Da Lecce (1425-1495)
"In the second half of the fifteenth century, Roberto Caracciolo's preaching touched the most important cities of Italy, and met with wide and resounding success. His sermons were read and diffused throughout Italy and Europe, propelled by the emergence of the printing press industry. This book provides a new and comprehensive study of his life, preaching and writing, replacing outdated resources and adding new and hitherto unknown data. It offers a reference work on a relevant social, intellectual and religious actor of Renaissance Italy and a reading of those times through the life and works of a celebrated preacher"--
