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Physiology and Pathophysiology of Musculoskeletal Aging
We live in a world with an ever-increasing aging population. This aging population is predicted to place a huge financial burden on healthcare systems around the world. Understanding healthy ageing is a key research priority, along with a better understanding of the pathophysiology of ageing that occurs in a number of age related diseases, such as arthritis. By gaining a better understanding of healthy musculoskeletal ageing we can provide better care and new therapies for common musculoskeletal problems. This Research Topic is intended to bring together basic researchers and clinicians working in the broad area of musculoskeletal ageing. The topic includes mechanisms of healthy ageing in the musculoskeletal system, which we define as skeletal muscle and the synovial joint, particularly constituent structures including articular cartilage, subchondral bone tendon and ligament. A particular focus of this Research Topic is dietary modulation of musculoskeletal ageing.
The Physiology of Inflammation – The Final Common Pathway to Disease
Chronic diseases are increasingly recognized as involving low grade inflammation, that is, a self-perpetuating tissue response to stress caused by exogenous or endogenous triggers, that progressively evokes danger-associated molecular pattern release, ultimately driving tissue damage and loss of function. This response is frequently unapparent clinically, thus the designation "low grade". This eBook comprises nineteen reviews and original articles that provide the most updated knowledge on the causes and roles of this inflammatory response in a variety of diseases and conditions. The editorial that precedes these articles not only summarizes each one, but provides a broader interpretation of the role of inflammation in health and a variety of disease conditions, the underlying mechanisms and the targets more promising for therapy. Finally, it also highlights the most relevant and emerging research topics that are already shaping future directions for the development of more fine-tuned and innovative therapies.
Facilitative Glucose Transporters in Articular Chondrocytes
Articular cartilage is a highly specialized avascular connective tissue. This multidisciplinary article reviews the molecular and morphological aspects of GLUT expression and function in chondrocytes and their mesenchymal and embryonic stem cell precursors.
Anais
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Revista de Guimarães
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O dever de declaração inicial do risco no contrato de seguro
O texto ora dado à estampa corresponde essencialmente à minha tese de Doutoramento em Direito pela Universidade de Lisboa, na especialidade de Ciências Jurídico-Empresariais, com o título Declaração do Risco no Contrato de Seguro: O Dever Pré-Contratual do Proponente. Fui admitido à preparação de provas em Dezembro de 2008, tendo o trabalho de investigação decorrido sob orientação do Professor Doutor Pedro Romano Martinez. A tese foi discutida e aprovada em provas públicas, que decorreram em 28 de Fevereiro de 2013, ano em que a Faculdade de Direito de Lisboa comemora o seu centenário. O Júri foi composto pelos Professores Doutores Pedro Romano Martinez (presidente), Júlio...
Chronology of Portuguese Literature
This is the first Chronology of Portuguese Literature to be published in any language. It presents a comprehensive year-by-year list of significant and representative works of literature published mainly in Portuguese from 1128 to the beginning of the current millennium. As a reference tool, it displays the continuity and variety of the literature of the oldest European country, and documents the development of Portuguese letters from their origins to the year 2000, while also presenting the year of birth and death of each author. This book is an ideal resource for students and academics of Portuguese literature and Lusophone cultures.
Boletim
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