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Arachidonate Remodeling and Inflammation
Arachidonic acid (AA) and other 20 or 22-carbon polyunsaturated fatty acids (PUFAs) are precursors of lipid mediators of inflammation known as eicosanoids. These mediators are critical in disease processes and in regulating normal cell function. Remodeling is important in maintaining homeostasis and in regulating cell function by dictating how PUFAs are converted to lipid mediators of inflammation. Thus, PUFA remodeling is a critical process in the biosynthesis of a multitude of mediators, and understanding this process will unravel better therapeutic targets for controlling inflammatory diseases such as asthma and Alzheimer’s disease. AA metabolism is described in an integrated context linking the remodeling processes with the biosynthesis of mediators and diseases. By following the movement of the substrate (AA), the volume describes how upstream biosynthetic pathways influence the formation of lipid mediators of inflammation, showing the metabolic interrelationship between all AA-derived mediators.
Eicosanoid Protocols
In Eicosanoid Protocols, Elias A. Lianos and a panel of hands-on experts present cutting-edge methods for the study of eicosanoids, including prostaglandins, thromboxanes, and leukotrienes. The readily reproducible methods described hereconcentrate on studying the regulation of expression and function of enzymes, particularly cyclooxygenase (and its two isoforms), phospholipase A2, and lipoxygenases involved in the synthesis of established eicosanoids. Additional chapters are devoted to the characterization and distribution of the thromboxane A2 receptor in tissues and the biological roles of novel eicosanoids. Timely and authoritative, the methods in this book will help their users in exploring the pathobiology of inflammation. Eicosanoid Protocols offers new and established researchers powerful, state-of-the-art tools to probe the regulation and function of eicosanoids.
Chronic Headache
This comprehensive, practical title invites all clinicians to take a fresh look at the evaluation and management of chronic daily headache (CDH). Developed by a distinguished international panel of experts, the book examines key social and economic issues around CDH and clarifies the diagnosis of CDH disorders, providing an understanding of the underlying biological substrates, offering guidance on the use of diagnostic testing and additional consultations, and outlining treatment strategies with the greatest potential to alleviate the burden of these patients and to provide the highest quality of care. The book fully examines the constellation of symptoms that constitute chronic daily heada...
Inflammation Nation
An internationally renowned scientist sounds the alarm about our country's most critical health issue and provides a simple eating plan that can help stop this secret epidemic one individual at a time. Here are the chilling statistics: ·One in three American adults suffers from arthritis. ·Sixty-four million people have heart disease in some form. ·Fifty million Americans suffer with allergies and 20 million have asthma. ·More than 18 million people have diabetes, with 1.3 million newly diagnosed each year. ·Sixty-five percent of American adults are over-weight or obese and 16 percent of children are overweight. At best, these conditions destroy our quality of life; at worst, they are p...
Disease Markers of the Nervous System
"The nervous system is important in controlling cognition and behaviors as well as bodily functions via the peripheral and autonomic pathways. A dysfunction in the nervous system results in diseases that are an increasing burden to modern medicine. Advances in the diagnosis, control and treatment of these diseases will require a comprehensive knowledge of the biochemical changes associated with specific brain functions. Brain functions are currently identified, and sometimes measured, by clinical structured interviews, coupled with imaging or neurophysiological procedures. Far fewer molecular based diagnostic methods, such as disease specific biomarkers, are available at this point to monito...
Phospholipases in Physiology and Pathology
Phospholipases in Physiology and Pathology presents a comprehensive overview on the physiology and pathology of phospholipases. This seven-volume set considers the biochemical and molecular mechanisms of normal and abnormal cell function upon dysregulation of phospholipases in different diseases. Volumes cover signal transduction mechanisms, implications in cancer, infectious diseases, neural diseases, cardiovascular diseases and other diseases, implications in inflammation, apoptosis, gene expression and non-coding RNAs, the role of natural and synthetic compounds, and stem cell therapies, nanotechnology-based therapies, and more. Together, these volumes give researchers critical insight on the mechanistic and therapeutic aspects of phospholipases. - Discusses the biochemical and molecular mechanisms of normal and abnormal cell function in different disease processes - Covers a wide range of basic and translational research appropriate for scientists engaged in studying the regulation of phospholipases from interdisciplinary perspectives - Features state-of-the-art chapter contributions from international leaders in the field
Apoptosis and Inflammation
Apoptosis is a form of cell death that occurs in a controlled manner and is generally noninflammatory in nature. Apoptosis, or programmed cell death, implies a cell death that is part of a normal physiological process of pruning of unneeded cells. However, many disease conditions utilize apoptosis for pathological ends, resulting in inappropriate cell death and tissue destruction. This book starts with an introduction that reviews the general characteristics of apoptosis, its regulation and its role in physiology and disease. Next, the book focuses on three areas as they relate to inflammatory cells and diseases. The first area consists of chapters on signals for apoptosis important to infla...
MIND Diet for Two
Boost your brain health with MIND diet recipes made just for two The MIND diet combines two of the healthiest diets in the world—the Mediterranean diet and the DASH diet—and can improve brain health and lower your odds of developing age-related problems. This comprehensive cookbook features MIND diet recipes made for just two people. You’ll both enjoy eating foods that protect and nourish the brain without all the leftovers. What sets this MIND diet cookbook apart: The power of the MIND diet—Learn the history of the MIND diet (Mediterranean-DASH Intervention for Neurodegenerative Delay) and why its focus on foods like whole grains, vegetables, and seafood is so good for the brain. Perfectly portioned recipes—Each of these mouthwatering recipes is designed for two people, so there’s no converting measurements, figuring out portion sizes, or dealing with lots of leftovers or waste. Simple steps and ingredients—Create a wide variety of delicious recipes that feature ingredients you can find at your local grocery store. Keep your mind healthy and sharp by eating the brain-boosting foods featured in the MIND Diet for Two.
