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Advances in Cancer Stem Cell Biology
In recent years, cancer stem cells have been recognized as important component in carcinogenesis and they seem to form the basis of many (if not all) tumor types. Cancer stem cells or "cancer cell like stem cells" have been isolated from various cancers of different origin (blood, breast, brain, skin, head and neck, thyroid, cervix, lung, retina, colon, pancreas and so on). Cancer stem cells - rare cells with indefinite proliferative potential that drive the formation and growth of tumours- seem to show intriguing relationships with physiological stem cells. Specifically, these cancer cells show significant similarities in the mechanisms that regulate self-renewal of normal stem cells. Moreover, tumour cells might directly arise from normal stem cells. Further, the cellular biology of cancer stem cells show a lot of similarities with normal stem cells.
Advances in Mitochondrial Medicine
Mitochondria are far more than the “powerhouse” of the cell as they have classically been described. In fact, mitochondria biological activities have progressively expanded to include not only various bioenergetic processes but also important biosynthetic pathways, calcium homeostasis and thermogenesis, cell death by apoptosis, several different signal transduction pathways mainly related to redox control of gene expression and so on. This functional and structural complexity may undergo important derangements so to justify the definition of ‘mitochondrial medicine’, which should include all the clinical consequences of congenital or acquired mitochondrial dysfunctions. There are act...
Advances in Cancer Biomarkers
At present there are a growing number of biomolecules under investigation to understand their potential role as cancer biomarker for diagnostic, prognostic and therapeutic purposes. Intriguingly, the state of art on cancer biomarkers research shows interesting and promising results together to clamorous failures. Also from a clinical point of view, there are contradictory results on routine clinical use of the present cancer biomarkers. Some patients may be simply monitored in their course by a periodic blood sample, but sometimes this monitoring shows dramatic limits. A lot of patients show serious and extensive relapses without significant change in serum concentrations of biomarkers teste...
Coenzyme Q
Since its discovery in 1957, Coenzyme Q has piqued the interest of scientists from a wide range of disciplines because of its bioenergetics, vitamin-like behavior, and interactions with antioxidant vitamins E and C. Coenzyme Q: Molecular Mechanisms in Health and Disease is a comprehensive treatise on this often-studied coenzyme. International exper
Fishes of Antarctica
The Antarctic fish fauna has evolved over a long period of geographic and climatic isolation. In the course of this evolution, Antarctic fish have developed specialized adaptations, some of which characterize these organisms as unique. In strong contrast to the continental shelf faunas elsewhere, the Antarctic shelf ichthyofauna is dominated by a single highly endemic group, the Notothenioidei. This group of perciform fish probably first appeared and diversified in the early Tertiary. The development of the Polar Front (referred to as the Antarctic Convergence in the older literature) resulted in a natural oceanographic barrier to migration in either direction, and thus became a key factor in the evolution of Antarctic fish. The dominance of the Antarctic continental shelf fauna by a single taxonomic group of fish provides a simplified natural laboratory for exploring the wealth of physiological, biochemical and ecological adaptations that characterize the fauna. Understanding of the patterns of adaptation in this highly specialized group of fish can tell us much about of evolution.
Flavonoids as Key Medicinal Components in Honey
This book provides fundamental knowledge on the potential medicinal properties of honey and secondary metabolites of flavonoids. The book was written as a result of the author's many years of scientific research in the field of testing the quality of Bosnian-Herzegovinian honey and its potentially medicinal properties, and numerous published studies examining the medicinal properties of flavonoids were analyzed during its writing. The book, by focusing on the medicinal properties of secondary metabolites of flavonoids, and their introduction into the human body through honey, represents one of the first scientific and educational works of its kind. This book is primarily intended for undergraduate and postgraduate students in the fields of natural sciences, medicine, pharmacy, agriculture, nutrition, and ecology, but it will also be of use to all those who are professionally involved in honey production or are interested in research in this field.
The SAGE Encyclopedia of Stem Cell Research
The SAGE Encyclopedia of Stem Cell Research, Second Edition is filled with new procedures and exciting medical breakthroughs, including executive orders from the Obama administration reversing barriers to research imposed under the Bush administration, court rulings impacting NIH funding of research based on human embryonic stem cells, edicts by the Papacy and other religious leaders, and the first success in cloning human stem cells. Stem cell biology is clearly fueling excitement and potential in traditional areas of developmental biology and in the field of regenerative medicine, where they are believed to hold much promise in addressing any number of intractable medical conditions. This ...
