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Bulletin
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Drug Development
This book represents a case study based overview of many different aspects of drug development, ranging from target identification and characterization to chemical optimization for efficacy and safety, as well as bioproduction of natural products utilizing for example lichen. In the last section, special aspects of the formal drug development process are discussed. Since drug development is a highly complex multidisciplinary process, case studies are an excellent tool to obtain insight in this field. While each chapter gives specific insight and may be read as an independent source of information, the whole book represents a unique collection of different facets giving insight in the complexity of drug development.
The São Paulo Law School and the Anti-Vargas Resistance (1938-1945)
The São Paulo Law School, the oldest institution of higher learning in Brazil, has long been the chief training center for that country’s leadership. For the members of the school’s secret Burschenschaft society, the training consisted principally in leading demonstrations for liberal causes, such as the abolition of slavery and the overthrow of the monarchy. During the Old Republic (1889–1930), the Brazilian presidency and other high posts in Rio de Janeiro were usually occupied by alumni of the powerful society, while its members in São Paulo continued to agitate for political reform. But in the 1920s, when they formed the Nationalist League and the Democratic Party, schisms result...
KURUPIRA
The narrative unfolds from a casual visit by the narrator Jack Tate to an exhibition on baroque painting in a gallery in London, when the adventures of Kurupira, a mythical figure of an Amazon Forest goblin with inverted feet and defender of the forest, begin, who offers himself as squire to the greatest English philosopher of this century, Sir Roger Scruton, and seizes his soul during his stay in Brazil. They fight against the 12 evil dragons that inhabit the vast Brazilian territory, symbols of the corruption of the 12 biggest Western moral values.Sir Roger is part of a successor group of the 12 knights of the legendary Round Table, along with Edmund Burke, Alexis de Tocqueville, T.S. Elio...
Metaheuristics
This book constitutes the refereed proceedings of the 14th International Conference on Metaheuristics, MIC 2022, held in Syracuse, Italy, in July 2022. The 48 full papers together with 17 short papers presented were carefully reviewed and selected from 72 submissions. The papers detail metaheuristic techniques. Chapter “Evaluating the Effects of Chaos in Variable Neighbourhood Search” is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
Flight Plan Africa
Following the 1952 reorganization of the Portuguese Air Force from the army and naval air arms, Portugal now had an entity dedicated solely to aviation that would bring it into line with its new NATO commitment. As it proceeded to develop a competence in modern multiengine and jet fighter aircraft for its NATO role and train a professional corps of pilots, it was suddenly confronted in 1961 with fighting insurgencies in all three of its African possessions. This development forced it to acquire an entirely new and separate air force, the African air force, to address this emerging danger. This is the story of just how Portuguese leadership anticipated and dealt with this threat, and how it a...
Trends and Advances in Information Systems and Technologies
This book includes a selection of papers from the 2018 World Conference on Information Systems and Technologies (WorldCIST'18), held in Naples, Italy on March27-29, 2018. WorldCIST is a global forum for researchers and practitioners to present and discuss recent results and innovations, current trends, professional experiences and the challenges of modern information systems and technologies research together with their technological development and applications. The main topics covered are: A) Information and Knowledge Management; B) Organizational Models and Information Systems; C) Software and Systems Modeling; D) Software Systems, Architectures, Applications and Tools; E) Multimedia Systems and Applications; F) Computer Networks, Mobility and Pervasive Systems; G) Intelligent and Decision Support Systems; H) Big Data Analytics and Applications; I) Human–Computer Interaction; J) Ethics, Computers & Security; K) Health Informatics; L) Information Technologies in Education; M) Information Technologies in Radiocommunications; N) Technologies for Biomedical Applications.
Lloyd’s Register of Yachts 1961
The Lloyd’s Register of Yachts was first issued in 1878, and was issued annually until 1980, except during the years 1916-18 and 1940-46. Two supplements containing additions and corrections were also issued annually. The Register contains the names, details and characters of Yachts classed by the Society, together with the particulars of other Yachts which are considered to be of interest, illustrates plates of the Flags of Yacht and Sailing Clubs, together with a List of Club Officers, an illustrated List of the Distinguishing Flags of Yachtsmen, a List of the Names and Addresses of Yacht Owners, and much other information. For more information on the Lloyd’s Register of Yachts, please click here: https://hec.lrfoundation.org.uk/archive-library/lloyds-register-of-yachts-online
Lloyd’s Register of Yachts 1966
The Lloyd’s Register of Yachts was first issued in 1878, and was issued annually until 1980, except during the years 1916-18 and 1940-46. Two supplements containing additions and corrections were also issued annually. The Register contains the names, details and characters of Yachts classed by the Society, together with the particulars of other Yachts which are considered to be of interest, illustrates plates of the Flags of Yacht and Sailing Clubs, together with a List of Club Officers, an illustrated List of the Distinguishing Flags of Yachtsmen, a List of the Names and Addresses of Yacht Owners, and much other information. For more information on the Lloyd’s Register of Yachts, please click here: https://hec.lrfoundation.org.uk/archive-library/lloyds-register-of-yachts-online
Lloyd’s Register of Yachts 1962
The Lloyd’s Register of Yachts was first issued in 1878, and was issued annually until 1980, except during the years 1916-18 and 1940-46. Two supplements containing additions and corrections were also issued annually. The Register contains the names, details and characters of Yachts classed by the Society, together with the particulars of other Yachts which are considered to be of interest, illustrates plates of the Flags of Yacht and Sailing Clubs, together with a List of Club Officers, an illustrated List of the Distinguishing Flags of Yachtsmen, a List of the Names and Addresses of Yacht Owners, and much other information. For more information on the Lloyd’s Register of Yachts, please click here: https://hec.lrfoundation.org.uk/archive-library/lloyds-register-of-yachts-online
