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Molecular mechanisms of cellular stress responses in cancer and their therapeutic implications
In response to stress, cells can activate a myriad of signalling pathways to bring about a specific cellular outcome, including cell cycle arrest, DNA repair, senescence and apoptosis. This response is pivotal for tumour suppression as all of these outcomes result in restriction of the growth and/or elimination of damaged and pre-malignant cells. Thus, a large number of anti-cancer agents target specific components of stress response signalling pathways with the aim of causing tumour regression by stimulating cell death. However, the efficacy of these agents is often impaired due to mutations in genes that are involved in these stress-responsive signalling pathways and instead the oncogenic ...
The Journal of Cell Biology
No. 2, pt. 2 of November issue each year from v. 19 (1963)-47 (1970) and v. 55 (1972)- contain the Abstracts of papers presented at the Annual Meeting of the American Society for Cell Biology, 3d (1963)-10th (1970) and 12th (1972)-
Protein Chaperones and Protection from Neurodegenerative Diseases
How protein chaperones protect cells from neurodegenerative diseases Including contributions from leading experts, Protein Chaperones and Protection from Neurodegenerative Diseases provides an in-depth exploration of how protein chaperones are involved in shielding cells from toxic aggregated or misfolded protein states that cause ALS, Parkinson's, and related diseases. Examining how different protein chaperones ameliorate the toxicity of proteins that are known to cause neurodegenerative damage, the book addresses both research and clinical perspectives on chaperone and anti-chaperone properties. The intersection of molecular chaperones and neurodegeneration is an intensely studied area, pa...
Unmasking metabolic dependencies for anti-cancer treatment in cancer
Over the last decade, our understanding of metabolism in the context of cancer has evolved greatly. It is now evident that altered cellular metabolism is an integral effector of tumorigenesis that is intricately intertwined with cell signaling as well as genetic and epigenetic regulation of diverse tumor programs. Recognizing the dysregulation of cellular metabolism as an important aspect of tumor function has offered new potential direction to seek clinical benefit by providing targets for the development of novel therapeutics. To-date, several small molecule inhibitors that target tumor or immune cell metabolism are being explored in active clinical trials as either preventive, stand-alone, or adjuvant therapies for various malignancies. Thus, identifying critical metabolic vulnerabilities in pre-neoplastic cells, cancer cells, and immune cells has direct and timely relevance for developing additional treatment and preventative strategies against cancer.
Sustainable Waste Management Challenges in Developing Countries
As global waste generation increases at a rapid rate, there is a dire need for waste management practices such as collection, disposal, and recycling to protect from environmental pollution. However, developing countries generate two to three times more waste, resort to open dumps more often than developed countries, and are slower to integrate waste management standards. There is a need for studies that examine the waste generation and practices of countries that share similar economic backgrounds as they strive to implement successful waste management techniques. Sustainable Waste Management Challenges in Developing Countries is an essential reference source that discusses the challenges and strategies of waste management practices and the unique waste issues faced by developing countries that prevent them from achieving the goal of integrated waste management. While highlighting topics including e-waste, transboundary movement, and consumption patterns, this book is ideally designed for policymakers, legislators, waste company managers, environmentalists, students, academicians, and municipal planners seeking current research on the global waste management problem.
Glycoimmunology
Proceedings of the Third Jenner International Glycoimmunology meeting held in Il Ciocco, Tuscany, Italy, October 11-14, 1994
The Gadfly
Ethel Lilian Voynich, nee Boole (1864-1960), was born and raised in Cork, Ireland. She is most famous for "The Gadfly" (1897), a novel about independence fighters in Italy that sold 2.5 million copies between 1897 and 1957. The book portrays a Catholic cardinal having an illegitimate son, which created a huge controversy at the time of its publication. "An historical novel, permeated with a deep religious interest" (The Critic), it was admired by D.H. Lawrence and Jack London and adapted for stage by George Bernard Shaw (1898). Composer Dmitri Shostakovich wrote "The Gadfly Suite" based upon the novel. Bertrand Russell called it the most exciting novel he had read in the English language.
