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Biologically Active Amines Found in Man
Biologically Active Amines Found in Man: Their Biochemistry, Pharmacology, and Pathophysiological Importance deals with the biochemistry, pharmacology, and pathophysiology of biologically active amines present in the human body. Emphasis is placed on amines derived by decarboxylation of a-amino acids in human beings and some of their especially interesting metabolites. This book consists of four chapters and opens with an overview of biogenic amines and their origin, followed by a discussion on their biochemistry, pharmacology, and pathophysiology. The metabolism and inactivation of biologically active amines such as tyramine, dopamine, noradrenaline, adrenaline, tryptamine, serotonin, and histamine are examined, along with their incorporation into the body protein and their rate of turnover. The influence of biologically active amines on the function of the kidneys, microcirculation, and respiratory metabolism is also considered. Finally, illnesses in which indigenous amines have known or possible/probable pathophysiological significance are described. This monograph will be of interest to biologists, biochemists, pharmacologists, and pathophysiologists.
Biogenic Amines
Biogenic amines (BAs) are low-molecular-mass organic bases that occur in plant- and animal-derived products. BAs in food can occur by free amino acid enzymatic decarboxylation and other metabolic processes. Usually, in the human body, amines contained in foods are quickly detoxified by enzymes such as amine oxidases or by conjugation; however, in allergic individuals or if monoamine oxidase inhibitors are applied, the detoxification process is disturbed and BAs accumulate in the body. Knowing the concentration of BAs is essential because they can affect human health and also because they can be used as freshness indicators to estimate the degree of food spoilage.
Mechanisms of Release of Biogenic Amines
Wenner-Gren Center International Symposium Series, Volume 5: Mechanisms of Release of Biogenic Amines provides information pertinent to the fundamental aspects of the release of biogenic amines. This book discusses the physiology, biochemistry, and pharmacology of the biogenic amines. Organized into 39 chapters, this volume begins with an overview of the release of amines, which is implicated in functional disturbances characteristic of different diseases. This text then examines the concepts of cell structure that are significant to the release of neurohumoral agents. Other chapters consider the fluorescence reaction, which made it possible to work out a practical histochemical procedure. This book describes as well a few examples in which the monoaminergic transmitter is not revealed as a diffuse cytoplasmic fluorescence. The final chapter deals with acetylcholine as the only brain amine investigated, which could be influenced by the tremorgenic agents during the period of tremor. This book is a valuable resource for biochemists, morphologists, pharmacologists, and physiologists.
Biogenic Amines
Biogenic amines (BAs) are low-molecular-mass organic bases that occur in plant- and animal-derived products. BAs in food can occur by free amino acid enzymatic decarboxylation and other metabolic processes. Usually, in the human body, amines contained in foods are quickly detoxified by enzymes such as amine oxidases or by conjugation; however, in allergic individuals or if monoamine oxidase inhibitors are applied, the detoxification process is disturbed and BAs accumulate in the body. Knowing the concentration of BAs is essential because they can affect human health and also because they can be used as freshness indicators to estimate the degree of food spoilage.
Biogenic Amines (BA)
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