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Identification of Biomarkers for Cancer Immunotherapy: From Bench to Bedside, volume I
During the past few decades, immunotherapy has become an established pillar of cancer treatment improving the survival of numerous patients with diverse solid and hematologic tumors. The leading causes behind the success are the discovery of immune checkpoint inhibitors (ICIs) and the development of chimeric antigen receptor (CAR) T/M/NK cells. As for ICIs, malignancies take advantage of the inhibitory programmed cell death protein 1/programmed cell death protein ligand 1 (PD-1/PD-L1) or cytotoxic T-lymphocyte-associated protein (CTLA-4) pathways to evade the immune system, and disruption of the axis by immune checkpoint inhibitors can achieve durable disease remissions, which has been prove...
Next Generation Kinase Inhibitors
Protein kinases are fascinating enzymes that maintain the proper function of nearly every task performed by the cells of the human body. By extracting a phosphate from the energy molecule ATP and linking it to another protein, protein kinases alter the structure and ultimate function of other proteins. In this way, protein kinases help monitor the extracellular environment and integrate signaling cues that, for the most part, are beneficial for human health and survival. However, protein kinases are often dysregulated and responsible for the initiation and progression of many types of cancers, inflammatory disorders, and other diseases. Thus, decades of research have revealed much about how ...
ENGINEERING CHEMISTRY FOR DIPLOMA
This book is written strictly for the first and second semester diploma students of engineering chemistry according to the revised syllabus. It aims to provide a thorough understanding of the chemical concepts, theories and principles in Engineering Chemistry in a clear and concise manner, so that the average students are able to grasp the intricacies of the subject. Explaining general concepts of atomic structure and chemical bond, the book covers all advanced topics such as acid–base theory, concentration of solutions, electrochemistry, corrosion, metallurgy, hydrocarbons, sources of water and its treatment, lubricants and adhesives, fuel, polymer and environmental chemistry. Each theoretical concept is well supported by illustrative examples. Besides, the book provides a large number of solved problems to reinforce the theoretical understanding of concepts. Each chapter contains glossary terms and provides short questions and long questions for practice. Previous year question papers and model questions with answers are appended at the end of the book to help students ace in examinations.
ENGINEERING CHEMISTRY WITH LABORATORY EXPERIMENTS
This book is primarily intended for the first year B.Tech students of all branches for their course on engineering chemistry. The main objective of this book is to provide a broad understanding of the chemical concepts, theories and principles of Engineering Chemistry in a clear and concise manner, so that even an average student can grasp the intricacies of the subject. It includes the general concepts of structure and bonding, phase rule, solid state, reaction kinetics and catalysis, electrochemistry, chemical thermodynamics and free energy. Besides, the book introduces topics of applied chemistry like water technology, polymer chemistry and nanotechnology. Each theoretical concept is well...
Cancer and Noncoding RNAs
Cancer and Noncoding RNAs offers an in-depth exploration of noncoding RNAs and their role in epigenetic regulation of complex human disease, most notably cancer. In addition to examining microRNAs, this volume provides a unique evaluation of more recently profiled noncoding RNAs now implicated in carcinogenesis, including lncRNAs, piRNAs, circRNAs, and tRNAs, identifying differences in function between these noncoding RNAs and how they interact with the rest of the epigenome. A broad range of chapters from experts in the field detail epigenetic regulation of various cancer types, along with recent next generation sequencing technologies, genome-wide association studies (GWAS) and bioinformat...
Vagus Nerve Stimulation
In the complex realm of our physiology, the vagus nerve stands as a silent orchestrator, influencing health and disease in ways that have long been underestimated. Vagus Nerve Stimulation delves into the profound significance of this 10th cranial nerve, tracing its course through the body and illuminating its role as a vital component of the parasympathetic nervous system. This comprehensive reference, contributed by leading experts at the forefront of medical science, unveils the groundbreaking field of vagus nerve stimulation—a non-invasive approach to harness the body's innate potential for health optimization, inflammation control, and disease modification. Contributed by leading exper...
Docking Screens for Drug Discovery
This book focuses on recent developments in docking simulations for target proteins with chapters on specific techniques or applications for docking simulations, including the major docking programs. Additionally, the volume explores the scoring functions developed for the analysis of docking results and to predict ligand-binding affinity as well as the importance of docking simulations for the initial stages of drug discovery. Written for the highly successful Methods in Molecular Biology series, this collection presents the kind of detail and key implementation advice to ensure successful results. Authoritative and practical, Docking Screens for Drug Discovery aims to serve those interested in molecular docking simulation and also in the application of these methodologies for drug discovery.
Plant Relationships
Since the publication of the first edition of "The Mycota Vol. V – Plant Relationships" in 1997, tremendous advances in fungal molecular biology and biochemistry have taken place; and both light and electron microscopical techniques have improved considerably. These new insights led to a better understanding of the relationships between fungi and plants; and a completely revised new edition of Plant Relationships could be produced, providing an up-to-date overview on mutualistic and pathogenic interactions. In 18 chapters internationally acknowledged authors present reviews on fungal lifestyles, mechanisms of their interactions with their host plants, signal perception and transduction, and plant defense responses directed against attack by fungal pathogens. Highlighting the recent developments in fungus-plant interactions, this volume is indispensable for researchers, lecturers and students in microbiology, mycology and plant sciences, including plant pathology.
Drugs for Pregnant and Lactating Women E-Book
Logically organized and easy to use, Drugs for Pregnant and Lactating Women, 3rd Edition, is your #1 resource for details on how virtually all of today's drugs and herbal supplements interact with pregnancy and lactation. More than just a dosing manual, this unique title by Dr. Carl P. Weiner fully explains whether each drug is FDA-approved for use by expecting or nursing mothers, is known to be safe for use, or is known to pose a danger. With up-to-date coverage of nearly 2,000 substances, it provides the thorough details you need to choose the most effective course of treatment. - Uses a consistent, easy-to-follow format for each substance: generic and trade name • class • indications ...
