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Generics and Bioequivalence provides a clear, insightful, and in-depth analysis of the many complex issues encountered in the determination of drug bioequivalence. Included are timely updates on many controversial and newly emerging areas in the design and analysis of bioavailability and bioequivalence studies. This new reference was prepared by a group of authorities from academe, industry, and government and can be easily understood by students and experienced scientists alike. Topics presented include the role of single and multiple dosing in the determination of bioequivalence, the role of metabolites in assessing bioequivalence, stereochemical considerations in bioequivalence evaluation, uses of animal models, pharmacodynamics, and statistics. The analysis of pharmacodynamic data (especially when plasma levels are unavailable) is covered, and the nascent importance of individual bioequivalence is examined.
The Truth Holds No Secrets tells the true story of Andre' Jackson, a cautionary tale from the beginning to the end. Living in this complex system where labor, war and prison bars have been a source to solutions and corruption. "Our World" where Truth is in such a great need, it has been protected and guarded by a body of lies, uncertain facts and just plain old greed for power. With a determined Spirit, actors can't copy, government can't own, state can't control and science has been trying to explain, the Word that Was and Is and Will Be. A Legend in every religion" as friendly as a debate can be." The Tautology of the Prince of Peace with a powerful step into Action. A Soul covered by Love, a Child blessed to know both Parents. A True Puzzle Master!
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Published in 1994: This text focuses on the determination of bioequivalence between formulations that are pharmaceutically equivalent and manufactured using acceptable chemistry, manufacturing and controls and in accordance with Good Manufacturing Practices.
The definitive biography of a larger-than-life president who defied norms, divided a nation, and changed Washington forever Andrew Jackson, his intimate circle of friends, and his tumultuous times are at the heart of this remarkable book about the man who rose from nothing to create the modern presidency. Beloved and hated, venerated and reviled, Andrew Jackson was an orphan who fought his way to the pinnacle of power, bending the nation to his will in the cause of democracy. Jackson’s election in 1828 ushered in a new and lasting era in which the people, not distant elites, were the guiding force in American politics. Democracy made its stand in the Jackson years, and he gave voice to the...
The Victorian East End lives in fear of the Ripper and his mission to kill rent boys. Silas Hawkins, nineteen and forging a life on the streets could well be the next victim, but when he meets Archer, his life changes forever. Young, attractive and rich, Archer is The Viscount Clearwater, a philanthropist, adventurer and homosexual. When Archer suspects the Ripper is killing to lure him to a confrontation, he risks his reputation and his life to stop the madman's murders. Every man must play his part, including Silas. Secrets must be kept, lovers must be protected, and for Archer and Silas, it marks the start of their biggest adventure - love. A mashup of mystery, romance and adventure, Devi...
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