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Reprint of the original, first published in 1876.
Metalloenzymes: From Bench to Bedside offers a thorough overview of metalloenzymes, spanning biochemical and structural features, pharmacology, and biotechnological applications. After a brief overview, international experts in the field discuss a wide range of magnesium, calcium, zinc, manganese, nickel, iron, copper, cadmium, molybdenum, and tungsten enzymes, along with catalytic roles within their active sites. With a uniform approach throughout, each chapter includes the structure and function of the enzyme, physiologic and pathologic roles, inhibitors and activators of the enzyme (and their design), and clinical agents or compounds applied in medicine and drug discovery. This book enables scientists across academia and industry to adopt ongoing metalloenzyme research, and continuous discovery of novel metalloenzymes, in new life science studies and clinical applications. - Examines a range of metalloenzymes, from biochemistry to pharmacology and drug design - Each chapter examines enzyme structure and function, physiologic and pathologic roles, inhibitors and activators, and clinical application - Features chapter contributions from international experts in the field
Bacterial Carbonic Anhydrases, Volume 55 in The Enzymes series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of timely topics, including Overview on bacterial CA genetic families, Bacterial a-CAs, Bacterial ß-CAs, Bacterial ?-CAs, Bacterial ?-CAs, Sulfonamide bacterial CA inhibitors, Non-sulfonamide bacterial CA inhibitors, Helicobacter pylori CA inhibition, Neisseria gonorrhea CA inhibition, Vancomycin resistant enterococci CA inhibition, Pseudomonas aeruginosa CA inhibition, Mycobacterium tuberculosis CA inhibition, and Challenges for developing bacterial CA inhibitors as novel antibiotics. - Provides the authority and expertise of leading contributors from an international board of authors - Presents the latest release in The Enzymes series - Highlights new advances on bacterial carbonic anhydrases
This book explains how lightweight materials and structures can be deployed in buildings to meet high environmental and aesthetic standards and emphasizes how the concept of lightness in building technology and design dovetails with the desire to enhance landscape. The first part of the book, on lightweight construction, aims to foster the use of membranes within the specific climatic context and in particular considers how lightweight materials and innovative technologies can enrich the quality of temporary spaces. The second part focuses exclusively on landscape, presenting novel approaches in the search for visual lightness and the quest to improve urban spaces. Particular attention is paid to the Italian experience, where the traditional appreciation of brick and stone has limited the scope for use of lightweight structures and membrane materials, often relegating them to a secondary or inappropriate role. The reader will come to appreciate how this attitude demeans a very advanced productive sector and neglects the ancient tradition of temporary architecture.