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Ancient Wine
Stone age wine -- The Noah hypothesis -- The archaeological and chemical hunt for the earliest wine -- Neolithic wine! -- Wine of the earliest pharaohs -- Wine of Egypt's golden age -- Wine of the world's first cities -- Wine and the great empires of the ancient Near East -- The Holy Land's bounty -- Lands of Dionysos : Greece and western Anatolia -- A beverage for King Midas and at the limits of the civilized world -- Molecular archaeology, wine, and a view to the future.
Adaptation in Natural and Artificial Systems
Genetic algorithms are playing an increasingly important role in studies of complex adaptive systems, ranging from adaptive agents in economic theory to the use of machine learning techniques in the design of complex devices such as aircraft turbines and integrated circuits. Adaptation in Natural and Artificial Systems is the book that initiated this field of study, presenting the theoretical foundations and exploring applications. In its most familiar form, adaptation is a biological process, whereby organisms evolve by rearranging genetic material to survive in environments confronting them. In this now classic work, Holland presents a mathematical model that allows for the nonlinearity of...
Forest Genomics and Biotechnology
Developments in genomics and biotechnology are opening up new avenues for accelerating the domestication of forest trees in a climate change-driven world. This book presents an authoritative update of forest tree biotechnology and genomics methodologies, procedures and accomplishments, from basic biological science to applications in forestry and related sciences. It gives expert evaluation of achievements and discussion about the impact that novel forest biotechnological and genomics approaches are having on traditional breeding for improvement of forest tree species and production of forest-based products. It also describes the legal and regulatory aspects of forest biotechnology, with an emphasis on biosafety. It is a reference for forest biologists, including basic and applied scientists involved in forest tree breeding and biotechnology, bioenergy research, biomaterial product development. It is a comprehensive text for graduate-level students in the areas of Plant Biology and Forest Genetics, Silviculture and Agroforestry, and Bioenergy Science and Technology.
Cardiac Arrhythmias
This book covers all the major aspects associated with pathophysiological development of cardiac arrhythmias (covering enhanced or suppressed automaticity, triggered activity, or re-entry), from basic concepts through disease association, limitations of current pharmacotherapy and implant therapies and on-going trials and analysis of new biomarkers based on current knowledge of cellular interaction and signalling. The book describes novel and state-of-the-art methods for differentiating between the major types of arrhythmia, structural abnormalities and current practice guidelines and determination of risk stratification associated with sudden cardiac death. A particular focus is on arrhythmias associated with atrial fibrillation and includes details of associations with cardiac disease, current detection, analysis and imaging and future perspectives.
Sepsis and Organ Dysfunction
An experienced physician knows how to recognize a patient suffering from sepsis, but cannot accurately determine whether the patient will survive. Cardinal elements of the treatment for sepsis include specific antibiotic and vasoactive drugs, enteral and parenteral nutrition, artificial respiration, and optimization of the oxygen transport to tissues. Nonetheless, with a certain frequency, these techniques are insufficient to ensure the recovery of a critically ill patient, especially when it is necessary to overcome functional alterations subsequent to organ and vital-system overload. The key elements in the progression of the sepsis-MODS syndrome are tied to numerous factors. These include: the severity and location of the lesion; the patient's age; the remaining functional reserve; the presence of mediatory which may be stimulatory, inhibitory or both.
Drug Delivery
In the view of most experts pharmacology is on drugs, targets, and actions. In the context the drug as a rule is seen as an active pharmaceutical ingredient and not as a complex mixture of chemical entities of a well defined structure. Today, we are becoming more and more aware of the fact that delivery of the active compound to the target site is a key. The present volume gives a topical overview on various modern approaches to drug targeting covering today’s options for specific carrier systems allowing successful drug treatment at various sites of the body difficult to address and allowing to increase the benefit-risk-ratio to the optimum possible.
