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Molecular, Clinical and Environmental Toxicology
Molecular Toxicology is the first volume of a three-volume set Molecular, Clinical and Environmental Toxicology that offers a comprehensive and in-depth response to the increasing importance and abundance of chemicals in daily life. By providing intriguing insights far down to the molecular level, this work covers the entire range of modern toxicology with special emphasis on recent developments and achievements. It is written for students and professionals in medicine, science, public health and engineering who are demanding reliable information on toxic or potentially harmful agents and their adverse effects on the human body.
Safety of Nanomaterials along Their Lifecycle
The incorporation of nanomaterials into products can improve performance, efficiency, and durability in various fields ranging from construction, energy management, catalysis, microelectronics, plastics, coatings, and paints to consumer articles such as foods and cosmetics. But innovation never comes at zero risk. The potential hazards resulting from human exposure during production, use, or disposal has raised concerns and targeted research early on. Safety of Nanomaterials along Their Lifecycle: Release, Exposure, and Human Hazards presents the state of the art in nanosafety research from a lifecycle perspective. Although major knowledge gaps still exist, solid data are now available to id...
Characterization of Nanoparticles
Characterization of Nanoparticles: Measurement Processes for Nanoparticles surveys this fast growing field, including established methods for the physical and chemical characterization of nanoparticles. The book focuses on sample preparation issues (including potential pitfalls), with measurement procedures described in detail. In addition, the book explores data reduction, including the quantitative evaluation of the final result and its uncertainty of measurement. The results of published inter-laboratory comparisons are referred to, along with the availability of reference materials necessary for instrument calibration and method validation. The application of these methods are illustrated with practical examples on what is routine and what remains a challenge. In addition, this book summarizes promising methods still under development and analyzes the need for complementary methods to enhance the quality of nanoparticle characterization with solutions already in operation.
Cancer: Cell Structures, Carcinogens and Genomic Instability
Tumors can be induced by a variety of physical and chemical carcinogens. The resulting tumor cells are usually abnormal in their morphology and behavior and transmit their abnormalities to their daughter tumor cells. Most theories of the pathogenesis of tumors suggest that carcinogens in some way cause alterations either of the genomes or of inheritable patterns of gene expression in normal cells, which then cause morphological and behavioral changes. This volume presents a collection of articles aimed at the question by what genetic or epigenetic mechanisms carcinogens can cause morphological abnormalities of tumor cells. It includes reviews of cellular targets of known carcinogens, and presents varying viewpoints of how morphological abnormalities and the actions of carcinogens might be related. The volume will be of interest to all those who are involved in cancer research or in the prevention, diagnosis or management of tumors in humans or animals.
The Carcinogenic Effects Of Polycyclic Aromatic Hydrocarbons
This book provides an overview on the molecular mode of action of carcinogenic polycyclic aromatic hydrocarbons (PAHs). PAHs are by-products arising from incomplete combustion of organic matter that are frequently released into our environment, and thus are ubiquitously detectable. Many PAHs are strong carcinogens in rodent bioassays and have been linked to increased incidences of various types of cancer in humans. The present book covers all aspects of PAH-induced carcinogenesis; it is a collection of articles written by some of the most recognizable PAH researchers, reviewing the present knowledge in this field. The topics include: exposure to and biomonitoring of PAHs in the human population; metabolic activation of PAHs; genotoxicity and repair of PAH-induced DNA damage; and factors modulating individual susceptibility to the deleterious effects of PAHs.
Nanophytomedicine
Nanophytomedicine is a field that involves the application of nanomedicine-based systems to phytotherapy and phytopharmacology. This book assesses the clinical successes and failures of nanophytomedicine and also highlights emerging concepts in this field. The content is divided into three sections, the first of which describes core issues in the pharmaceuticals industry in connection with the successes, failures and prospects of nanophytomedicine. The second section highlights recent advances in phytomedicine formulation development based on nanotechnology approaches, while also discussing a variety of nanocarrier systems for the successful delivery of phytomedicines. Focusing on the clinic...
Collective Behavior of Magnetic Micro/Nanorobots
Collective Behavior of Magnetic Micro/Nanorobots: Control, Imaging, and Applications reviews recent advances in the design and construction of magnetic collective micro/nanorobot systems, and promotes the bridging of the gap between their theoretical investigation and practical applications. By summarizing the recent progress in control, imaging, and biomedical applications of collective micro/nanorobots, the authors show the big picture of micro/nanorobotics and the roadmap of collective micro/nanorobots. They then discuss the control, imaging, and biomedical applications of collective micro/nanorobots, respectively, demonstrating the state-of-the-art techniques and ideas for designing systems of collective micro/nanorobots that can help researchers have a better understanding and further stimulate the development of such an exciting field. This book is suitable for scientists, engineers, and students involved in the study of robotics, control, materials, and mechanical/electrical engineering.
Pharmakon
Pharmakon: Plato, Drug Culture, and Identity in Ancient Athens examines the emerging concern for controlling states of psychological ecstasy in the history of western thought, focusing on ancient Greece (c. 750-146 BCE), particularly the Classical Period (c. 500-336 BCE) and especially the dialogues of the Athenian philosopher Plato (427-347 BCE). Employing a diverse array of materials ranging from literature, philosophy, medicine, botany, pharmacology, religion, magic, and law, Pharmakon fundamentally reframes the conceptual context of how we read and interpret Plato's dialogues. Michael A. Rinella demonstrates how the power and truth claims of philosophy, repeatedly likened to a pharmakon,...
Nanoparticles in Cancer Therapy
This book presents the role of nanoparticles in cancer therapy, emphasizing their innovative applications across treatment, diagnosis and the development of therapeutic strategies. The first section of the book describes the applications of nanoparticles in cancer vaccines and gene therapy. It features discussions on polymeric nanoparticles as nanovaccine carriers, membrane-based nano-vaccines for immunotherapy and gene therapy techniques employing nanoparticles. The second section presents advanced nanomedicine approaches, specifying the role of chemodynamic nanoparticles in cancer theranostics, the application of low-dimensional nanomaterials and emerging strategies against drug resistance...
