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Scale and the Incas
A groundbreaking work on how the topic of scale provides an entirely new understanding of Inca material culture Although questions of form and style are fundamental to art history, the issue of scale has been surprisingly neglected. Yet, scale and scaled relationships are essential to the visual cultures of many societies from around the world, especially in the Andes. In Scale and the Incas, Andrew Hamilton presents a groundbreaking theoretical framework for analyzing scale, and then applies this approach to Inca art, architecture, and belief systems. The Incas were one of humanity's great civilizations, but their lack of a written language has prevented widespread appreciation of their sop...
Functional Synthetic Receptors
A timely overview of this rapidly-expanding topic, covering the most important classes of compounds and incorporating the latest literature. With its application-oriented approach, this book is the first to emphasize current and potential applications, extending to such fields as materials science, bioorganic chemistry, medicinal chemistry, and organic synthesis. In the biological context in particular, the book clarifies which receptor systems work well in water or better under physiological conditions. From the contents: * Amino Acid, Peptid and Protein Receptors * Carbohydrate Receptors * Ammonium, Amidinium and Guanidinium Receptors * Anion Receptors * Molecular Capsules and Self Assembly * Dynamic Combinatorial Libraries based on Molecular Recognition * Molecular Machines * Self-Replication Aimed at graduate students and specialists in the field, this is also of interest to pharmaceutical companies involved in drug design, as well as chemical companies with a polymer or nanotechnology group. In addition, analytical companies working on the advanced equipment covered here will find stimulating new applications.
Drug Discovery Research
Post Genomics Drug Discovery and Research explores and discusses some of the most important topics in post-genomics life and biopharmaceutical sciences. It provides an introduction to the field, outlining examples of many techniques currently used, as well as those still under development, which are important for the research of biopharmaceutical discovery in the post-genomics era. Integrates several developing and cutting-edge technologies and methods like bioinformatics, experimental therapeutics, and molecular recognition Includes discussion on topics such as: computer-aided ligand design; peptide and protein chemistry and synthesis; synthesis of active natural products; and the use of emerging technologies like proteomics, nanotechnology, or bioengineering.
Macrocyclic and Supramolecular Chemistry
This book commemorates the 25th anniversary of the International Izatt-Christensen Award in Macrocyclic and Supramolecular Chemistry. The award, one of the most prestigious of small awards in chemistry, recognizes excellence in the developing field of macrocyclic and supramolecular chemistry Macrocyclic and Supramolecular Chemistry: How Izatt-Christensen Award Winners Shaped the Field features chapters written by the award recipients who provide unique perspectives on the spectacular growth in these expanding and vibrant fields of chemistry over the past half century, and on the role of these awardees in shaping this growth. During this time there has been an upsurge of interest in the desig...
The Jewish World of Alexander Hamilton
"In his hit musical "Hamilton," Lin-Manuel Miranda paints Founding Father Alexander Hamilton as the ultimate outsider, the "bastard, orphan, son of a whore," who by sheer grit and smarts achieves political greatness, leaving a permanent mark on the American landscape as the architect of its financial system. In this book Andrew Porwancher argues that the first Secretary of the Treasury and chief author of "The Federalist Papers" was even more of an outsider than previous biographers have noted. Porwancher has uncovered evidence strongly suggesting that Hamilton was born and raised as a Jew - at least until the age of 13, when his mother died. The evidence is not definitive, but it is compell...
Molecular Gels
Molecular gels and fibrillar networks – a comprehensive guide to experiment and theory Molecular Gels: Materials with Self-Assembled Fibrillar Networks provides a comprehensive treatise on gelators, especially low molecular-mass gelators (LMOGs), and the properties of their gels. The structures and modes of formation of the self-assembled fibrillar networks (SAFINs) that immobilize the liquid components of the gels are discussed experimentally and theoretically. The spectroscopic, rheological, and structural features of the different classes of LMOGs are also presented. Many examples of the application of the principal analytical techniques for investigation of molecular gels (including SA...
Supramolecular Protein Chemistry
Building on decades of “host-guest” research, recent years have seen a surge of activity in water-soluble supramolecular receptors for protein recognition and assembly. Progress has been particularly rich in the area of calixarenes, cucurbiturils and molecular tweezers. Emerging applications include controlled protein assembly in solution, crystal engineering, supramolecular control of catalysis (both in vitro and in vivo), as well as novel mechanisms of protein-interaction inhibition with relevance to amyloids and disease. One challenge at the interface of supramolecular chemistry and protein science is to increase interaction and collaboration between chemists and biochemists/structura...
The Self Sufficient-Ish Bible
Identical twin brothers Andy and Dave Hamilton live in the centre of Bristol. Attracted to the pub and music scene of the bustling city, they still yearn for elements of the good life. So ever since they were students, they have used their initiative and imagination to think up ways to live in a frugal and self-sufficientish way, while still enjoying life to the full. Having set up their website www.selfsufficientish.com in 2004, they discovered that their approach and ethos touched a nerve with thousands of people in the UK. Andy and Dave, Britains green twins, advocate a fun and positive approach to environmentalism, and understand that the thought of adjusting every aspect of our lives is...
Advances in Amino Acid Mimetics and Peptidomimetics
Peptidomimetics are compounds which mimic the biological activity of peptides while offering the advantages of increased bioavailability, biostability, bioefficiency, and bioselectivity against the natural biological target of the parent peptide. Examples of peptidomimetics have been isolated as natural products, synthesized as libraries from novel subunits, and designed on the basis of X-ray crystallographic studies and through an intricate knowledge of the biological mode of action of natural peptides. They offer challenging synthetic targets and are increasingly important medicinal agents and biological probes. As a consequence, peptidomimetics embrace much of what is modern medicinal and organic chemistry. This volume highlights some recent and exciting developments in the area.
Supramolecular Science
A summary of all the most important aspects of supramolecular science, from molecular recognition in chemical and biological systems to supramolecular devices, materials and catalysis. The 17 chapters cover calixarenes, catenanes, cavitands, cholophanes, dendrimers, membranes and self-assembly systems, molecular modelling, molecular level devices, organic materials, peptides and protein surfaces, recognition of carbohydrates, rotaxanes, supramolecular catalysis. A forward-looking chapter written by J.-M. Lehn indicated the future prospects for the entire field. Audience: Ph.D. students and young researchers in chemistry, physics and biology.
