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Molecular Mechanisms of Adult Stem Cell Aging
"There is growing evidence that adult stem cells age. This process can result in alterations in the number and function of stem cells, leading to distinct phenotypic outcomes in different organ systems. This publication provides an outstanding overview of this emerging field. The molecular causes of stem cell aging remain to be defined. Stem cell aging can involve cell-intrinsic as well as cell-extrinsic alterations affecting the stem cell niche or the macroenvironment. Stem cells have a longer life span than other cell populations and retain a capacity to proliferate and differentiate in adult organs. The aging of adult stem cells plays a key role in the decline of organ maintenance and reg...
Advances in Stem Cell Aging
Up-to-date meeting report of the Else Kr ner-Fresenius Symposium on Adult Stem Cell Aging Adult stem cells are present in most postnatal tissues of mammals. Tissues with high rates of cell turnover depend on the functional capacity of stem cells for lifelong maintenance of tissue homeostasis. Adult stem cells are also required for the regeneration of tissues in response to injury as in, for example, the regeneration of skeletal muscle. In addition to its function in tissue homeostasis and regeneration, adult stem cells can represent the cell type of origin of various types of cancers including leukemia and colorectal cancer. Stem cells are the most long-lived cells in the proliferative compa...
British Postal Guide
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Mismatch Unemployment
We develop a framework where mismatch between vacancies and job seekers across sectors translates into higher unemployment by lowering the aggregate job-finding rate. We use this framework to measure the contribution of mismatch to the recent rise in U.S. unemployment by exploiting two sources of cross-sectional data on vacancies, JOLTS and HWOL, a new database covering the universe of online U.S. job advertisements. Mismatch across industries and occupations explains at most 1/3 of the total observed increase in the unemployment rate, whereas geographical mismatch plays no apparent role. The share of the rise in unemployment explained by occupational mismatch is increasing in the education level.
Braunkohlesanierung
Die Braunkohlesanierung ist eines der größten Umweltprojekte Europas. Ca. 30 Braunkohlentagebaue und fast 90 Standorte von Kraftwerks- und Veredlungsanlagen werden seit Anfang der 90er Jahre des 20. Jahrhunderts im Raum Halle/Leipzig und in der Lausitz saniert. Ziel ist die Beseitigung von Umweltschäden und die Wiederherstellung attraktiver und sicherer Landschaften nach dem Bergbau. Dieses Vorhaben ist beispiellos und es mussten neue Wege beschritten werden. Das Buch informiert Praktiker und Studierende über den Stand der Technik und des Wissens der komplexen Sanierung von Bergbaufolgelandschaften. Wie werden solche Großvorhaben geplant, genehmigt, organisiert und finanziert? Welche te...
Annual Report
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