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Pediatric Neurology Part III
Myasthenia gravis in children can be generalized or ocular, and associated with antibodies to acetylcholine receptors or muscle-specific kinase, but it can be negative for those antibodies (seronegative). It needs to be distinguished from congenital myasthenic syndromes and other neuromuscular diseases. In the perinatal period, transient neonatal myasthenia and arthrogryposis multiplex congenita, due to maternal antibodies, need to be considered. Juvenile myasthenia is similar in presentation and treatment to that in adults. Here we present guidelines for recognition, diagnosis, and treatment.
Autoantibodies in Neurological Diseases
The book covers the immunological and clinical aspects of immune-mediated diseases of the central and peripheral nervous system, excluding multiple sclerosis. It includes paraneoplastic neurological disorders, and discusses the immune mechanisms in the growing number of recognised paraneoplastic conditions. It not only provides an overview of the field but also discusses the possible role of immunity in other neurological disorders such as epilepsy. Chapters are written by scientists and clinicians directly involved in each specific area, who have summarized the current understanding of neuroimmunology, with emphasis on the underlying abormalities of the immune responses, the different clinical expression of the diseases and the important use of immunotherapies in treatment. Figures and tables are included in each chapter.
Autoimmune Neurology
Autoimmune Neurology presents the latest information on autoimmune neurologic disease, the immune response to the body where organs run wild, causing the immune system to attack itself. Autoimmunity is a main element in numerous nervous system diseases and can target any structure within the central or peripheral nervous system. Over the past 20 years, significant advances in our understanding of the pathophysiology of autoimmune disorders, including the use of biomarkers has led to new diagnosis and treatment options. Neurologic conditions associated with autoimmune reactions include dementia, neuromuscular disease, epilepsy, sleep disorders, diabetes, and other common neurologic disorders ...
Inflammatory and Autoimmune Disorders of the Nervous System in Children
Inflammatory disorders of the nervous system, although individually uncommon, collectively make up 10-20% of acute paediatric neurology presentations and many are potentially treatable. Research into them is lagging behind adult research, but better diagnosis and often simple treatments could lead to substantial clinical benefit and reduction in long-term disability. This book provides a detailed and comprehensive summary of the childhood diseases that are, or are likely to be, caused by the immune system. The authors not only describe these disorders and their treatments comprehensively, helping pediatricians and pediatric neurologists to improve their understanding and recognition of the conditions, but also highlight recent and exciting developments that will be of considerable importance in the future.
Pediatric Neurology Part I
Apart from Rasmussen encephalitis, other immune-mediated brain disorders have emerged that are frequently associated with recurrent epileptic seizures: (1) limbic encephalitis, (2) anti-N-methyl-D-aspartate-receptor (NMDAR) encephalitis, and (3) steroid-responsive encephalopathy associated with autoimmune thyroiditis (SREAT, formerly called Hashimoto encephalopathy). Limbic encephalitis mainly affects the mediotemporal aspect of the cortex giving rise to temporal lobe seizures and memory and affective disturbances. It can occur as a paraneoplastic or, even more frequently, a nonparaneoplastic condition. Detection of specific autoantibodies may suggest underlying cancer (onconeural antibodies...
Neuromuscular Transmission
Aims to provide an account of the structure and development of the neuromuscular junction, the biochemical and physiological events associated with neuromuscular transmission, the use of toxins as probes and the molecular structure of ion channels and other proteins involved.
Clinical Neuroimmunology
Clinical Neurimmunology is the major reference text in the field, providing broad and comprehensive coverage of the interaction between the nervous and immune systems in both normal and diseased states. Understanding this interaction is fundamental to developing therapeutic approaches to disease and injury of the nervous system that are currently only marginally amenable to therapy. Neuroimmunology is a well-recognised and growing specialty world wide, both at the basic science and clinical level. It is a fast moving field and this is the most up to date text available. Chapters are dedicated to the role of the immune system in disorders affecting both the central and peripheral nervous syst...
Romanticism, Rousseau, Switzerland
This collection brings together current research on topics that are perennially important to Romantic studies: the life and work of Jean-Jacques Rousseau, and the landscape and history of his native Switzerland.
First Lady
This book is about five women who are first ladies of their church. Their husbands are pastors of megachurches in the United States. All five women are friends in the ministry. They come together for a retreat, just the five of them. But they have to make some major decisions that will affect the lives of their husbands and their churches. But it will also make you see that they are normal people with everyday problems. This book is based on the real sisterhood of five real first ladies, but the names of the characters and their story are fictional.
The Testament of Vida Tremayne
A lonely novelist, A devoted fan, A journal that speaks of unspeakable things... Author Vida Tremayne lies silent in a hospital bed. The forces which brought about her terrifying decline are shrouded in mystery. Meanwhile, her estranged daughter Dory is forced to abandon her fast paced city life to be by her mother's bedside. Dory is resentful. She hates the country and she and her mother were never exactly close. Luckily Vida already has a carer, the enigmatic Rhiannon Townsend. A long-standing fan of Vida's, Rhiannon is happy to take care of the bedside vigil. Dory is free to resume her life. Or is she? Then she discovers her mother's journal. Vida's chilling testament reveals the trigger for her spiralling into madness. It also reveals the danger that still lurks close by. A danger that will call on Dory's every reserve of courage if she's to free her mother, and maybe in doing so, to free herself.
