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Breast cancer is the most frequently diagnosed cancer and the leading cause of cancer death in women worldwide, accounting for nearly a quarter of the total new cancer cases each year. Of these cases, approximately 15–25% overexpress HER2, a transmembrane RTK kinase that is associated with aggressive tumor growth and poor outcomes. However, in the past decade, survival rates of patients with HER-positive breast cancer have significantly improved due to increased screening, HER2 testing, and breakthrough HER2-targeted drug therapies. Handbook of HER2-Targeted Agents in Breast Cancer provides oncologists, primary care physicians, trainees and other healthcare providers with a concise, accessible, and up-to-date survey of the field, including a review of our current understanding of the biology of the HER2 pathway and the rationale for targeting it in early-stage and advanced breast cancer, an overview of HER2-testing, and evidence-based discussions of available HER2-targeted regimens in the adjuvant and metastatic settings.
Cartas produzidas como uma fina costura, daquelas que se fazem por muitas mãos. Uma grande tessitura, colorida, afetiva e esperançosa. Uma produção elaborada pelos sujeitos que fizeram de vários sábados, ao longo do ano de 2022, momentos de escuta, leitura, ensinamento e aprendizado. Escritas com muitos destinatários, inclusive para si, para o eu em diferentes temporalidades, revestidas de inúmeras intencionalidades. São relatos pessoais, relatos sobre desafios da prática docente cotidiana, pautada na responsabilidade ética que produz a boniteza de aprender-ensinar-aprender.
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