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Revisiting Seed and Soil: A New Approach to Target Hibernating Dormant Tumor Cells, 2nd edition
Metastasis is the major cause of mortality in cancer patients. Metastases can be present at the time of diagnosis or can occur years or decades after the removal of the primary tumor and treatment. This long latency in the manifestation of recurrent metastatic disease is explained clinically by the persistence of quiescent tumor cells that disseminated early in the course of the disease from the primary tumor to select distant organs. These residing disseminated tumor cells (DTCs) at distant organs lay dormant and asymptomatic until reawakened to form overt metastases. Importantly, the quiescent nature of these “hibernating” DTCs facilitates their resistance to conventional therapies tha...
Pharmacoresistance in Epilepsy
Although more than 10 new antiepileptic drugs have been developed in the past decade, epilepsy remains resistant to drug therapy in about one third of patients, many of whom struggle with the disease their entire lives. Managing these patients is a challenge and requires a structured multidisciplinary approach. The book includes chapters on all issues related to pharmacoresistance in epilepsy and describes recent developments in the pathogenesis and treatment of this disorder. It addresses abnormalities in inhibitory mechanisms, epilepsy-related changes to the immune system, development of pharmacoresistance caused by chronic exposure to antiepileptic drugs, and novel therapeutic strategies ...
Diversity of the Microbial World
Microbes, or microorganisms, are tiny living beings that cannot be seen by the naked eye. These little guys are one of the oldest living things on Earth, and are extremely diverse in how they live and what they can do. They, for example, can live in many places, from the freezing iciness of glaciers, to the insides of other organisms, like termites or humans. Since they are virtually everywhere, microorganisms are essential for the biological processes that allow plants and animals to breath, eat and thrive. But how were they able to endure, adapt and flourish constantly over millions of years? The secrets of their success are still within them, coded into their genomes, waiting for us to un...
POLÍTICA ANGÉLICA
Esta es la primera edición crítica y anotada de la Política angélica de Antonio Enríquez Gómez, impresa en Ruan en 1647. Estos cinco diálogos conforman un verdadera summa política y un intento por diseñar una ciencia del gobierno. Frente a la política satánica que domina el mundo, el autor propone una política angélica construida a partir de las Sagradas Escrituras. Esa nueva política garantiza la libertad de conciencia, favorece la virtud, la justicia y la misericordia y antepone el mérito al linaje.
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Ethnobotany of the Mountain Regions of Mexico
Research in recent years has increasingly shifted away from purely academic research, and into applied aspects of the discipline, including climate change research, conservation, and sustainable development. It has by now widely been recognized that “traditional” knowledge is always in flux and adapting to a quickly changing environment. Trends of globalization, especially the globalization of plant markets, have greatly influenced how plant resources are managed nowadays. While ethnobotanical studies are now available from many regions of the world, no comprehensive encyclopedic series focusing on the worlds mountain regions is available in the market. Scholars in plant sciences worldwi...
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The Paradox of Paternalism
Latin American Studies Association Haiti-Dominican Republic Section Isis Duarte Book Prize From the rise of dictator Rafael Trujillo in the early 1930s through the twelve-year rule of his successor Joaquín Balaguer in the 1960s and 1970s, women are frequently absent or erased from public political narratives in the Dominican Republic. The Paradox of Paternalism shows how women proved themselves as skilled, networked, and non-threatening agents, becoming indispensable to a carefully orchestrated national and international reputation. They garnered concrete political gains like suffrage and paved the way for their continued engagement with the politics of the Dominican state through intense p...
Nazi Literature in the Americas
Featuring several mass-murdering authors, two fraternal writers at the head of a football-hooligan ring and a poet who crafts his lines in the air with sky writing, Roberto Bolaño's Nazi Literature in the Americas details the lives of a rich cast of characters from one of the most extraordinary imaginations in world literature. Written with sharp wit and virtuosic flair, this encyclopaedic group of fictional pan-American authors is the terrifyingly humorous and remarkably inventive masterpiece which made Bolaño famous throughout the Spanish-speaking world.
Validity of Educational Assessments in Chile and Latin America
This edited volume presents a systematic analysis of conceptual, methodological and applied aspects related to the validation of educational tests used in Latin American countries. Inspired by international standards on educational measurement and evaluation, this book illustrates efforts that have been made in several countries to validate different types of educational assessments, including student learning assessments, measurements of non-cognitive aspects in students, teacher evaluations, and tests for certification and selection. It gathers the experience of validity studies from the main international assessments in Latin America (PISA, TIMSS, ERCE, and ICCS). Additionally, it shows t...
