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The Living Laboratory for Precision Medicine
The Living Laboratory for Precision Medicine: Last-mile Solutions for Delivering Precision Medicine provides a comprehensive resource realizing the promise of precision medicine through a convergence of innovation and solutions across multiple domains - large population cohorts, artificial intelligence, genomics, phenomics, clinical trials, health economics and regulation exemplified by the living lab concept. The living lab is envisioned as an ecosystem for precision medicine discovery, delivery, and innovation, which can also act as a stimulus for regional economic growth. The term precision medicine has been popularized by clinical, scientific, political, financial and technological inter...
Special Issues in Hypertension
This book is not intended as a full detailed report on hypertension and related disorders, but instead focuses on particular issues in hypertension. It looks at emerging recently described forms of hypertension that are frequently encountered in clinical practice (prehypertension, white-coat and masked hypertension, hypertension in the elderly) and discusses novel aspects of target organ disease (for example, cognitive impairment, dementia, and sexual dysfunction), and changing concepts in the management of hypertension and antihypertensive pharmacotherapy. It also looks at specific topics that are rarely discussed in books, including hypertension control in postmenopausal women on hormonal replacement therapy, Ramadan fasting, painful inflammatory disorders, and aldosterone escape. Finally, it examines newer cardiovascular risk factors (for example, uric acid, circadian blood pressure changes, blood pressure variability).
Hypertension and Heart Failure
This book explains how hypertension affects 20-50% of the adult population in developed countries. Heart failure is the result of the hypertension's effects on the heart and it represents a growing public health problem. In this context the international scientific community is continuously struggling to develop better strategies in screening, diagnosing and treating hypertension and its deleterious effects. Thus, this field is continuously changing, with new important information being added constantly. This volume will offer both insights into the intimate mechanisms of transition from hypertension to heart failure and clinical practice advice on the prevention and treatment of heart failu...
Disorders of Blood Pressure Regulation
This book aims to present a comprehensive classification of hypertensive phenotypes based on underlying target organ involvement. Particular emphasis is placed on review and assessment of clinical presentation, pathophysiologic mechanisms, and possible specific therapeutic options for each hypertension phenotype. Several of these phenotypes are well known and well described in the literature, such as prehypertension, white coat and masked hypertension, isolated systolic hypertension, renovascular hypertension, endocrine hypertension, pediatric hypertension, and gestational hypertension. Other hypertension phenotypes, however, are not widely recognized, being reported only in special reviews;...
Society and Genetic Information
The genetic era has given rise to significant legal dilemmas: who may own genetic data, when can a genetic test be performed on children, how can genetic-based discrimination be avoided, or to what extent and in what ways can genetic data be protected? The book addresses the social, ethical, and legal implications of collecting, storing, analyzing, and commercializing genetic information. Prominent biologists, medical doctors, lawyers, anthropologists, philosophers, sociologists, and theologians from different countries provide their views on the complex biological and social impacts of the imminent proliferation of genetic information. The authors explore the various uses and applications of genetic information, and discuss the current dilemmas of making laws in the field of genetics. Different models of national genome projects and biobanks, as well as the related international legal documents and national laws are also discussed. Various genome projects and biobanks are analyzed in detail.
Textbook of Vascular Medicine
This textbook focuses on the vascular biology and physiology that underlie vascular disorders in clinical medicine. Vascular biomedicine is a rapidly growing field as new molecular mechanisms of vascular health and disease are unraveled. Many of the major cardiovascular diseases including coronary artery disease, heart failure, stroke and vascular dementia are diseases of the vasculature. In addition vascular injury underpins conditions like kidney failure and cardiovascular complications of diabetes. This field is truly multidisciplinary involving scientists in many domains such as molecular and vascular biology, cardiovascular physiology and pharmacology and immunology and inflammation. Cl...
Resistant Hypertension
A growing number of people suffer from so-called resistant hypertension, that is to say, high blood pressure that does not respond to treatment. This disorder is of great current interest and importance for public health, being a common clinical problem faced by both primary care clinicians and specialists. Furthermore, as older age and obesity are among the strongest risk factors for uncontrolled hypertension, the incidence of resistant hypertension will likely increase as the population becomes more elderly and heavier. While the prognosis of resistant hypertension is unknown, cardiovascular risk is undoubtedly increased since patients often have a history of long-standing, severe hyperten...
Essential Hypertension and Its Causes
This new account of the pathogenesis of essential hypertension (EH) represents a detailed analysis of the main components of the circulatory control system. The latter's properties resemble those of man-made adaptive control systems in which regulatory parameters are altered when operating conditions exceed certain limits, often through neural mechanisms. Inheritance of EH depends on both genes and environment. The high blood pressure (BP) genes have not yet been definitively identified, whilst the main environmental causes are mental stress, high dietary salt intake and obesity. EH occurs as two major syndromes, each initiated by chronic stress: 1) Stress-and-salt related EH, and 2) Hyperte...
The Lancet: Cardiovascular Disease 2012
This book, featuring content from the Aug 11, 2012, issue of The Lancet, has been released to coincide with the European Society of Cardiology (ESC) meeting in Munich, Germany, which is to be held on Aug 25–29, 2012. The Lancet is strongly supportive of cardiology as can be seen from the substantial relevant content in this compilation. In 2011, The Lancet published more papers in this specialty than any other: cardiovascular research contributed about one in four of all published research papers. Featured within are three research articles on lipids and cardiovascular disease which provide balance on the role of high density lipoproteins in cardiovascular disease, and on statins in preven...
Manual of Hypertension of the European Society of Hypertension, Third Edition
The Manual of Hypertension of the European Society of Hypertension reflects emerging concepts that have the potential to impact diagnostic and therapeutic approaches to hypertension. Updating all material, this new edition also delves into a number of areas that have received heightened interest in recent years or have become a matter of debate due to the controversial interpretation of the available data. FEATURES Reflects emerging concepts impacting diagnostic and therapeutic approaches Explores background, history, epidemiology, and risk factors Describes pharmacological, nonpharmacological, and medical treatments Examines hypertension in special populations and treatment
