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This concise, easy-to-read book summarizes the current clinical evidence and basic science relating to aging and the skin, assisting the clinician in addressing skin problems in older dermatologic patients. Each chapter focuses on a particular area in which new knowledge has rapidly emerged over the past 5 years, ensuring that the book is completely up-to-date. Recent insights into aging skin from basic and translational science are first discussed, covering the underlying genetics and the potential role of topical agents and procedures in reversing the aging process. Evidence-based prescribing in older patients is then explained, and the evidence relating to treatments for psoriasis, review...
This concise, comprehensive book provides the most recent updates on rosacea management strategy, pathophysiology, genetic and environmental contribution, comorbidities, and other various topics. It meets the market need for a book that examines topics that are not typically included in rosacea textbooks. Beginning with a discussion on the current clinical understanding of the disease, this book reviews the aforementioned topics in a thorough yet accessible fashion. Complete with tables detailing a variety of drugs in an unbiased manner as well as color photos of real patients, each chapter aims to relay useful, practical information to dermatologists at every stage in their career. A valuable contribution to the Updates in Clinical Dermatology Series, Rosacea aims to promote the rapid and efficient transfer of medical research into clinical practice for the benefit practitioners and patients alike.
Clinical Dermatology Trials 101 provides dermatologists with a handbook that allows them to become familiar with all aspects of clinical trials. Everything from obtaining the necessary tools and equipment, complying with local, federal, and international guidelines and regulations, and hiring and training staff for the safe and up-to-date conduct of dermatology clinical trials is covered. Written by leading experts in the field, Clinical Dermatology Trials 101 is the only clinical trial how-to available for dermatologists. With skin disease affecting nearly seventy percent of the population over a lifetime, and the rate of development of new drugs and devices for dermatologic use increasing at an exponential rate, there is a tremendous need for training and developing dermatology clinical research facilities to expedite the translation of basic and applied research, from bench to bedside. This is useful for practicing dermatologists, academic dermatologists, dermatology residents, clinical research fellows, dermatology fellows, research scientists, industry dermatologists, and medical students.
Basal Cell Carcinoma: Advances in Treatment and Research provides a comprehensive overview of evidence-based treatment approaches for the most common cancer worldwide - basal cell carcinoma. The first part of this book details the epidemiology, risk factors, pathophysiology, and different histologic subtypes of basal cell carcinoma highlighted with high-resolution histopathology images. The second part of the book provides an in-depth review of different treatment modalities including topical therapy, local immunotherapy with interferon, cryotherapy, electrodesiccation and curettage, radiotherapy, and surgical approaches with Mohs micrographic surgery, head and neck surgery, and oculoplas...
Since the 1970s I have pursued three separate but overlapping and sometimes simultaneous careers: (1) philosopher / writer / teacher / historian of the long nineteenth century, 1789-1914; (2) editor / translator / photographer / publisher / biographer / encyclopedist; (3) cataloging librarian / rare books and special collections librarian / historian of medicine. Somehow these three vocations have garnered me some acclaim, even an entry in Who's Who in America. Each of them has resulted in some published or presented works. Because these works have been scattered in a wide variety of venues, some of which have gone out of print or have otherwise become generally unavailable - and of course with the oral presentations being gone as soon as they are given - I have thought it wise to select, epitomize, and bring them together in one place - here. Thus, what follows in these volumes is what I consider to be the most important of my shorter works.
Skin is our primary interface with the environment, and T cells are crucial for orchestrating host immune responses against pathogenic microorganisms. Dysregulated immune responses, on the other hand, can result in chronic inflammatory skin diseases. The complex regulatory networks include effector T cells, memory T cells, regulatory T cells, immunoregulatory co-signaling molecules and cytokines that control skin immunity, and the mechanisms that regulate skin immune responses in host defense and in immune-mediated cutaneous diseases. The immune-regulatory networks are involved in the common inflammatory skin diseases, including psoriasis, atopic dermatitis, alopecia areata, vitiligo, bullous diseases, and cutaneous adverse drug reaction. The goal of this Research Topic is to provide a forum to advance research on the contribution of skin inflammation to the genesis and development of the skin diseases as well as to explore innovative skin-oriented pharmacological interventions, mainly on the immune regulatory networks, in the attempt to achieve a beneficial impact on the skin disease course.
Since the 1970s I have pursued three separate but overlapping and sometimes simultaneous careers: (1) philosopher / writer / teacher / historian of the long nineteenth century, 1789-1914; (2) editor / translator / photographer / publisher / biographer / encyclopedist; (3) cataloging librarian / rare books and special collections librarian / historian of medicine. Somehow these three vocations have garnered me some acclaim, even an entry in Who's Who in America. Each of them has resulted in some published or presented works. Because these works have been scattered in a wide variety of venues, some of which have gone out of print or have otherwise become generally unavailable - and of course with the oral presentations being gone as soon as they are given - I have thought it wise to select, epitomize, and bring them together in one place - here. Thus, what follows in these volumes is what I consider to be the most important of my shorter works. All translations are my own unless otherwise indicated.
This book presents current topics in genetics in the dermatologic field. Various skin disorders are inherited as mendelian inheritance. Genetic skin disorders are caused by mutations in the genes encoding proteins expressing in skin, skin appendages, melanocytes and immune-associated cells. Identification of genes and elucidation of function of the encoded proteins may provide novel strategies to overcome the disorders. We hope that this book offers sufficient current information in each disorder to scientists, physicians and dermatologists, and that novel therapies will be provided to affected individuals via these chapters.
The AACR Annual Meeting is the focal point of the cancer research community, where scientists, clinicians, other health care professionals, survivors, patients, and advocates gather to share the latest advances in cancer science and medicine. From population science and prevention; to cancer biology, translational, and clinical studies; to survivorship and advocacy; the AACR Annual Meeting highlights the work of the best minds in cancer research from institutions all over the world.
Modern oculofacial plastic surgery as a field is quite young, with the majority of the literature and leaders in the field developing since the 1950s. As such, the body of literature is quite small compared to other fields. Currently, there is no unified source where readers can learn about the core manuscripts that drive clinical decision-making and influence thought. This book gathers over 50 foundational studies in the oculoplastics field and provides commentary on each study. Discussion of each study includes the abstract, in-depth commentary on the strengths, limitations, and implications of each paper, and guidance for further reading on the topic with a brief review. A short remark by an author from the paper will provide additional color commentary on the inspirations and challenges involved in conceiving and conducting the study. Foundational Papers in Oculoplastics is relevant for anyone who is interested in oculoplastics (ophthalmologists, oncologists, plastic surgeons, etc.) and provides a nice overview of the field with interesting personal anecdotes from those who helped establish it.