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Trends On The Role Of Pet In Drug Development
Drug development is very expensive and a fight against time. PET offers possibilities to speed up this process by adding unique in vivo information on pharmacokinetics/dynamics of a drug at an early stage. This information can help decision makers to move the drug in the drug development process or to decide to stop further developments. This unique and complete book highlights the different ways PET can be used and describes the latest trends in the various disciplines within nuclear medicine to further improve methodologies and increase the number of tools to accelerate drug development. Various topics within tracer development, instrumentation, data analysis and many clinical and preclinical topics are described by leading scientists from industry and academia.
Cardiac Positron Emission Tomography
Myocardial viability has become one of the most important issues in clinical cardiology. In particular, absence or presence of viability may be decisive in patient management, and the decision to perform angioplasty (PTCA) or bypass surgery (CABG) is frequently based on the accurate assessment of viability. Although echocardiography and conventional nuclear medicine techniques may provide valuable information on viability, positron emission tomography (PET) is currently considered to be the gold standard for the assessment of myocardial viability. The simultaneous evaluation of myocardial metabolism and perfusion allows precise delineation and accurate quantification of residual myocardial v...
The Lexical Basis of Sentence Processing
This volume highlights current theories of the lexicon from the perspective of its use in sentence understanding. It includes work from researchers in psycholinguistic studies on sentence comprehension.
Extreme Religious Behaviours
Certain religious behaviours clearly reduce biological fitness. These behaviours include celibacy along with various forms of asceticism, and rituals that harm the performer. Such behaviours are found in widely different cultures. How is this possible? This book shows that these behaviours (as is religion in general) are by-products of features of the human mind whose evolutionary fitness is beyond doubt and explores those features. Which are those features? This book proposes a twofold answer. It draws attention to the layered nature of human consciousness, in which different manners of experience are superimposed on each other. This goes a long way toward accounting for the universal relig...
Quality in Nuclear Medicine
This comprehensive textbook provides a state of the art overview of the means by which quality in patient care is ensured within the field of nuclear medicine. Acknowledged experts in the field cover both management aspects, such as laws, standards, guidelines, patient safety, management instruments, and organisations, and specific issues, including radiation safety and equipment. Quality in Nuclear Medicine not only presents detailed information on the topics discussed but should also stimulate further discussion and offer an important tool to all professionals in the field of nuclear medicine and their stakeholders. Readers will find that the book provides a wealth of excellent guidance and reflects the pioneering role of nuclear medicine in advancing different aspects of quality within medicine.
The Wondering Brain
This book argues that the profounded questions raised by cognitive neuroscience may best be answered through a dialogue with religion.
Language in Our Brain
A comprehensive account of the neurobiological basis of language, arguing that species-specific brain differences may be at the root of the human capacity for language. Language makes us human. It is an intrinsic part of us, although we seldom think about it. Language is also an extremely complex entity with subcomponents responsible for its phonological, syntactic, and semantic aspects. In this landmark work, Angela Friederici offers a comprehensive account of these subcomponents and how they are integrated. Tracing the neurobiological basis of language across brain regions in humans and other primate species, she argues that species-specific brain differences may be at the root of the huma...
PET Studies on Amino Acid Metabolism and Protein Synthesis
Parameters such as membrane transport, metabolism and protein incorporation govern the fate of amino acids in living tissue. Is it possible to use positron tomography to measure some of them, and what is their meaning in normal and pathological situations? These questions have been addressed for a long time and no satisfactory answer has yet been given. This book, which derives from an EEC workshop organized in the frame of the Concerted Action on `PET Investigation of Cellular Regeneration and Degeneration', held in Lyon in February 1992, gives the present state of knowledge in this field based on the most recent studies. Contributions from 24 leading European and American scientists are presented and discussed in the following four parts: biochemistry and animal studies; amino acids labelling with positron emittors, quality control and metabolites measurement; kinetic modelling of amino acids transport, metabolism, and protein incorporation; clinical use of amino acids. This book will aid and interest biochemists, radiochemists, pharmacologists, neurologists, oncologists and medical imaging scientists.
Advances and Technical Standards in Neurosurgery
As an addition to the European postgraduate training system for young neurosurgeons we began to publish in 1974 this series of Advances and Technical Standards in Neurosurgery which was later sponsored by the European Association of Neurosurgical Societies. This series was first discussed in 1972 at a combined meeting of the Italian and German Neurosurgical Societies in Taormina, the founding fathers of the series being Jean Brihaye, Bernard Pertuiset, Fritz Loew and Hugo KrayenbtihI. Thus were established the principles of European co operation which have been born from the European spirit, flourished in the European Association, and have throughout been associated with this series. The fac...
The Oxford Handbook of English Grammar
This handbook provides an authoritative, critical survey of current research and knowledge in the grammar of the English language. The volume's expert contributors explore a range of core topics in English grammar, covering a range of theoretical approaches and including the relationship between 'core' grammar and other areas of language.
